Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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1,000+

Network Architect Jobs in Missouri

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$184K - $230K *

Shape the future of product security by leading architecture reviews and risk mitigation strategies. Collaborate with engineering and compliance teams to embed security throughout the development life...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Partner with us to drive innovative solutions as a Principal Architect, engaging in multi-faceted pre-sales and delivery efforts. Collaborate with teams and clients to enhance customer experiences and...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Drive the design and enhancement of corporate security infrastructure, improving automation and maintaining strong security posture in a cloud environment. Collaborate with teams to implement controls...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $185K *

Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$124K - $138K *

Transform mission-critical outcomes as a Senior Systems Engineer with expertise in MBSE and digital engineering. Drive program milestones, mentor junior engineers, and lead complex systems engineering...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Aerospace & Defense

$82K - $123K *

Champion AI innovation by driving tool adoption, engineering practices, and workforce enablement across the enterprise. Collaborate with cross-functional teams, influencing leaders and building future...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$98K - $206K *

Join a team that architects Oracle Fusion PPM solutions to enable precise project management and financial accountability for Marine Corps initiatives. Leverage your expertise to lead configurations a...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$175K *

Shape the future of global telecommunications by leading strategy, architecture, and operations for voice and video infrastructure, ensuring reliable and cost-effective communication services aligned...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$138K - $185K *

Transform your career by leading enterprise data and AI architecture initiatives. Collaborate with cross-functional teams to drive technology adoption and ensure alignment with business needs while in...

1 week ago

  •   5 - 7 years exp.  •   Food & Beverages

$135K - $160K *

Shape the future of online payments by driving revenue growth and optimizing checkout experiences. Collaborate with sales and engineering teams to influence product strategy and enhance customer relat...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$200K - $250K *

Unlock innovative infrastructure solutions by collaborating with cross-functional teams to design scalable architectures that meet client needs and enhance operational efficiency across data centers...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$150K - $204K *

Lead the design and implementation of innovative IT solutions, driving transformation for enterprise clients while ensuring alignment with business goals. Collaborate across teams to craft technical s...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$103K - $138K *

Unlock potential by designing and automating secure, scalable AWS cloud platforms. Collaborate with cross-functional teams to enhance infrastructure reliability and streamline software delivery throug...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Staffing

$110K - $130K *

Transform project execution by leading teams, managing labor, and ensuring compliance with safety and quality standards. Collaborate with project managers to drive efficiency and profitability across...

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$90K - $110K *

Champion security excellence by enhancing operational resilience and privacy. Collaborate with cross-functional teams to implement robust cybersecurity measures, ensuring compliance and protecting ent...

3 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$150K - $180K *

Lead the charge in delivering high-value design-build projects, ensuring quality execution from design to completion. Collaborate with diverse teams and mentor staff while managing budgets and client...

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$119K - $161K *

Shape your career as a Cloud Engineer by optimizing deployment processes, managing vendor integrations, and ensuring efficient cloud operations across various environments. Drive success through innov...

Reposted 3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$120K - $140K *

Transform your career by leading complex design change projects from inception to execution. Collaborate with cross-functional teams, manage substantial budgets, and drive innovation in a fast-paced e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$183K - $306K *

Drive the architectural vision for a cutting-edge platform, ensuring scalability, security, and efficiency. Collaborate across teams to modernize systems while maintaining client trust and operational...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$110K - $135K *

Drive exceptional service delivery by managing a global IT support team, ensuring high-quality technical guidance and client satisfaction while fostering a culture of excellence and continuous improve...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$63K - $111K *

Transform your career by joining a dynamic team as a Security Technician, where you'll travel to install, troubleshoot, and maintain advanced electronic systems, ensuring operational excellence across...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$130K - $160K *

Lead engineering efforts by writing production code and mentoring a team. Drive modernization initiatives through Java microservices while managing performance and growth of engineers. Collaborate wit...

United StatesRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$157K - $283K *

Transform transit operations by leading complex Automatic Train Supervision initiatives. Drive collaboration across technical and operational teams, ensuring system performance and reliability for maj...

United StatesRemote

2 weeks ago

  •   15+ years exp.  •   Real Estate & Construction

$80K - $95K *

Optimize our internal IT systems and security posture while managing user access, supporting AWS operations, and ensuring compliance. Collaborate with the COO to enhance efficiency and maintain a secu...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$145K - $157K *

Transform space operations by leveraging Kubernetes to deliver resilient solutions. Collaborate within an Agile framework to enhance software deployment, ensuring optimal performance and security for...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.