Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$95K - $125K *

Elevate security practices by integrating SAST/DAST into CI/CD pipelines, hardening infrastructure with Ansible, and ensuring compliance with federal standards. Collaborate on vulnerability management...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $110K *

Deliver strategic leadership and operational oversight to enhance decision-making processes within the Veterans Health Administration's EHRM, ensuring effective collaboration and communication across...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$80K - $95K *

Join a team that's dedicated to maximizing client success through effective software implementations. Collaborate with customers and partners to ensure timely project delivery while continuously impro...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Drive capital project execution and engineering improvements in a manufacturing facility. Lead projects from concept to completion, ensuring adherence to safety, quality, budget, and schedule while en...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$192K - $215K *

Drive strategic growth by leading a high-performing team to enhance customer success and revenue in key accounts, aligning regional strategies with corporate goals while fostering strong relationships...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Enterprise Technology

$190K - $210K *

Lead the charge in strategic AI initiatives, coordinating cross-functional teams to drive program success. Utilize your program management expertise to align priorities, manage risks, and enhance AI c...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$175K - $210K *

Architect transformative R&D initiatives that leverage AI and ML, ensuring platform stability and excellence. Join dynamic teams to drive innovation and quality in clinical technology solutions at a g...

RemoteRemote

Reposted 2 days ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$156K - $166K *

Champion laboratory data strategy and architecture for a transformative pharmaceutical initiative. Lead data governance, mapping, and migration planning while collaborating with cross-functional teams...

RemoteRemote

2 days ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Transform data engineering processes by building and optimizing scalable ETL pipelines in a dynamic environment, contributing to critical Oracle ERP projects ensuring compliance and data integrity for...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$220K - $250K *

Drive the product roadmap for Unify Release Orchestration, enhancing developer experience while coordinating releases across multiple services, engaging customers, and leading initiatives for AI-nativ...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $145K *

Pioneer the future of technical content as you drive strategy and execution for Render's content factory, ensuring accuracy and relevance for AI agents and developers. Collaborate closely with teams t...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$105K - $130K *

Unlock potential by leading a dynamic DevOps team to enhance continuous delivery infrastructure, ensuring operational efficiency and security while fostering collaboration and innovation in a fast-pac...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$170K - $316K *

Empower innovation by serving as a key legal advisor on product development, privacy, and emerging technologies. Collaborate with cross-functional teams to navigate complex regulations and ensure comp...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$75K - $158K *

Elevate your career by leveraging your expertise in business analysis to enhance Momentum Financials and Acquisitions. Collaborate with stakeholders to drive process improvements and ensure effective...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Information Technology

$195K - $235K *

Drive innovation in autonomous systems by building robust platforms for AI agents, ensuring seamless execution and user-friendly interfaces while tackling complex distributed systems challenges across...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$170K - $210K *

Elevate project outcomes by leading controls design for data center developments. Collaborate with clients and teams to ensure high-quality automation solutions, integrating advanced technologies and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$132K - $193K *

Drive data excellence as an Epic-certified Clarity/Caboodle Administrator, ensuring optimal database performance and reliable ETL operations in a hospital environment. Collaborate with teams to enhanc...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $145K *

Lead security initiatives by collaborating with cross-functional teams to embed security in the software development lifecycle, ensuring robust protection for high-risk product areas while driving ado...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$74K - $130K *

Join a dynamic team to oversee project administration and correspondence management, ensuring effective communication and compliance. Support project policies and enhance documentation workflows to dr...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$85K - $135K *

Lead the integration and evaluation of utility-scale energy storage systems, focusing on battery technology. Collaborate with R&D and engineering teams to enhance product performance and ensure compli...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$180K - $220K *

Drive strategic growth and client leadership in the Science and Tech market, leading high-performance teams to implement business plans and enhance brand presence while fostering innovative solutions...

United StatesRemote

Today

  •   11 - 15 years exp.  •   Real Estate & Construction

$83K - $104K *

Empower your career by collaborating on innovative electrical designs for mission-critical facilities. Engage with senior engineers, enhance your skills, and contribute to impactful projects while wor...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Technical Services

$122K - $187K *

Grow your career by driving strategic sales initiatives within key accounts. Collaborate with C-suite executives to deliver tailored technology solutions, ensuring exceptional customer experiences whi...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Elevate your career by managing Computer System Assurance projects, ensuring compliance with global regulations and quality standards. Lead teams to develop validation strategies that guarantee data i...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$160K - $192K *

Elevate cybersecurity solutions by driving revenue growth through strategic sales, managing the full sales lifecycle, and building strong relationships with clients and partners to enhance market pres...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.