Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$120K - $145K *

Accelerate commercial growth by defining strategies for product families, collaborating across teams to translate market insights into actionable plans that drive revenue, profitability, and customer...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Healthcare

$95K - $115K *

Manage server installations and maintenance, troubleshoot network issues, and ensure data integrity. Collaborate with teams to optimize data center operations and support business needs through effect...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's dedicated to solving complex software challenges. As a Sr. Software Engineer, you'll design, build, and maintain robust applications while collaborating across teams to enhance our...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$60K - $120K *

Unlock potential by deploying and supporting advanced robotic systems in diverse environments. Collaborate with teams, troubleshoot issues, and enhance client experiences through effective communicati...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$150K - $180K *

Join us to architect a unified web platform that enhances user experience across multiple services. Lead front-end development, optimize performance, and mentor engineers while ensuring seamless integ...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$143K - $200K *

Innovate solutions as a Senior Appian Developer, tackling complex BPM challenges. Collaborate with teams to design, implement, and optimize high-performance applications while mentoring junior develop...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$128K - $188K *

Drive your career with impactful technical sales in the medical device sector. Lead customer engagements, identify new business opportunities, and collaborate with cross-functional teams to enhance pr...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Champion innovative solutions as a Delivery Lead, guiding Oracle Cloud Financial implementations for diverse clients. Leverage your expertise to optimize technology strategies and enhance business out...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$80K - $95K *

Join us to operate and maintain critical MEP systems in supercomputing data centers. You'll ensure peak performance through hands-on troubleshooting and process optimization, directly supporting our m...

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Join a team that's driving strategic partnerships in Retail and Hospitality. Manage relationships with technology providers, identify growth opportunities, and develop compelling business cases to enh...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$130K - $155K *

Lead the charge in delivering high-quality cost management services for large-scale data center projects. Collaborate with clients and stakeholders to ensure project objectives are met throughout the...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Pioneer seamless pharmacy integrations by managing e-prescribing workflows, ensuring compliance, and optimizing operations. Become the go-to expert for pharmacy software, enhancing patient medication...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$176K - $265K *

Elevate customer engagement and market expansion by leading a high-performing team of Key Account Managers. Drive strategic sales initiatives, cultivate executive relationships, and ensure disciplined...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$62K - $118K *

Empower the development of manufacturing automation solutions by collaborating with engineers, troubleshooting systems, and participating in project lifecycles to enhance your skills in a hands-on env...

4 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$90K - $100K *

Transform business needs into actionable requirements, driving system enhancements and operational improvements. Collaborate across teams to ensure clarity and alignment, leveraging data analysis and...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$150K - $180K *

Innovate and lead the MyGeotab workflows, ensuring usability and reliability while driving evolution and collaboration across product domains to enhance customer experience and operational efficiency...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Transportation

$120K - $145K *

Empower digital transformation by leading Drupal modernization initiatives, guiding architecture strategies, and enhancing enterprise web platforms for improved performance, security, and user experie...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$160K - $210K *

Lead the charge in transforming Cyber Governance, Risk & Compliance through innovative data, AI, and automation strategies. Drive measurable outcomes and modernize technology platforms while building...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Finance & Insurance

$350K - $380K *

Lead the charge in driving growth within the U.S. Army by developing strategic relationships and capturing opportunities in Air Defense and Counter-UAS programs, ensuring alignment with mission needs...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$112K - $179K *

Architect the migration of legacy health data into MHS GENESIS, leading a team to ensure seamless integration and data quality. Collaborate with stakeholders to define architecture and standards, driv...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$108K - $181K *

Create impactful technical solutions in military electrification projects. Collaborate with defense clients and provide expertise throughout the proposal process, ensuring compliance and mission effec...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Business Services

$65K - $108K *

Unlock potential by providing advanced technical support and engineering expertise to resolve complex production issues. Manage end-to-end case ownership while collaborating with teams to enhance serv...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Innovate software solutions to enhance capabilities at the Naval Research Lab, focusing on full lifecycle support for web applications, user interfaces, and database tools while collaborating within a...

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$110K - $130K *

Elevate software capabilities by designing, developing, and maintaining applications. Collaborate with a dynamic team to support full lifecycle software for web tools, databases, and containers in a f...

2 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$135K - $145K *

Drive innovative software solutions by developing robust, cloud-native systems that enhance provider data management capabilities and meet the evolving needs of clients in a dynamic, collaborative env...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.