Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$120K - $145K *

Join a dynamic team to drive the development of a cutting-edge marketplace, enhancing provider products and economic incentives while collaborating closely with engineering and operations to transform...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Drive financial governance by tracking budgets, analyzing variances, and generating reports in a federal mission environment. Collaborate with cross-functional teams to ensure compliance and support e...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$140K - $160K *

Join a dynamic team to execute complex physical electrical designs for medium- and high-voltage substations and utility-scale projects, ensuring quality and compliance from concept through constructio...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Champion the full sales cycle for top enterprise accounts, utilizing a consultative approach to solve complex challenges. Drive impactful relationships with stakeholders, and navigate lengthy processe...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$175K - $250K *

Lead the architectural strategy for Operational Technology, ensuring integration with enterprise objectives. Strategically influence technical decisions and guide multi-disciplinary teams in deliverin...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$120K - $145K *

Lead strategic product initiatives in advanced surgical technologies, driving development and commercialization efforts. Collaborate with cross-functional teams to enhance orthopedic outcomes and proc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $120K *

Drive strategic initiatives to uncover and expand business opportunities, generating new sales through targeted contracts and executive-level relationships while mentoring sales teams and managing cus...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Information Technology

$180K - $200K *

Join a dynamic team as a strategic leader to drive the public sector channel strategy, focusing on the U.S. federal market. Build relationships, execute go-to-market plans, and empower partners to del...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$150K - $180K *

Transform the infrastructure landscape by leading Site Reliability Engineering and platform architecture for global expansion, ensuring reliability, cost efficiency, and compliance across multiple ser...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $170K *

Elevate enterprise sales by leading full-cycle engagements with large insurance carriers, leveraging consultative selling and technical fluency to drive value through innovative solutions and strategi...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $180K *

Join a team that's redefining product marketing in cybersecurity. Lead a small team to craft compelling narratives, drive go-to-market strategies, and collaborate across functions to ensure product su...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $231K *

Accelerate progress at the forefront of SAP integration, driving complex data exchanges and ensuring compliance with DoD standards while enhancing transportation operations across diverse systems...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$170K - $190K *

Elevate business systems by leading NetSuite management and integrations. Collaborate with cross-functional teams to ensure scalable, reliable processes while leveraging AI for development. Mentor a t...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$325K - $425K *

Unlock potential by driving cloud solutions sales in the public sector, cultivating strategic relationships, and exceeding revenue goals through innovative approaches and collaboration with internal a...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Technical Services

$150K - $180K *

Lead the charge in driving partner-sourced revenue growth and market expansion through strategic alliances in Data, AI, and Cloud. Collaborate with top technology partners to convert relationships int...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$75K - $158K *

Engage as a key Oracle Application DBA supporting a high-profile multi-agency program. Leverage your experience in Oracle E-Business Suite management to ensure optimal performance and uptime, while en...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$61K - $129K *

Join a team that's dedicated to optimizing CMDB health and governance. Leverage your expertise in ServiceNow to implement, maintain, and enhance data quality initiatives while collaborating with cross...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $185K *

Join a dynamic team as you design and develop CAD plugins, ensuring seamless integration with civil design workflows and GIS systems. Collaborate closely with engineers to enhance data management and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$125K - $160K *

Elevate your career by owning electrical application engineering for prefabricated platforms. Collaborate across disciplines to deliver scalable solutions, ensuring design integrity and execution read...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$175K - $200K *

Optimize our data infrastructure platform by enhancing automation, observability, and stability. Drive architectural changes to support long-term service requirements while ensuring high throughput an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$94K - $122K *

Empower operational excellence by providing technical support for production systems. Lead complex projects as a subject matter expert, enhancing system performance and driving process improvements th...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Transportation

$150K - $180K *

Engage with key healthcare clients to drive strategic account management, fostering relationships and delivering tailored solutions across GE HealthCare’s diverse portfolio, while leading cross-functi...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Business Services

$130K - $155K *

Lead the charge in creating cutting-edge embedded software solutions for autonomous mobile robotics. Drive technical excellence, oversee collaborative engineering efforts, and ensure high reliability...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$120K - $145K *

Join a dynamic team to architect and oversee cybersecurity and integration for a statewide Health Information Exchange, ensuring secure data management and compliance with healthcare standards while l...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $145K *

Lead the technical architecture and cybersecurity strategy for a statewide Health Information Exchange, ensuring secure integration and compliance with healthcare privacy standards while managing vend...

1 week ago

  •   11 - 15 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.