Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$105K - $163K *

Transform database environments by leading architecture and administration efforts across multiple platforms, ensuring compliance and performance for mission-critical applications in a dynamic, remote...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$100K - $120K *

Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $110K *

Shape the financial landscape by driving month-end close processes, ensuring general ledger accuracy, and enhancing accounting practices in a dynamic, multi-revenue stream environment. Collaborate to...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$113K - $191K *

Empower innovation in safety technology by developing AI-driven solutions that enhance customer experiences and operational efficiency. Collaborate across teams to deliver scalable, impactful products...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $95K *

Engage in dynamic business development within the defense sector, identifying and nurturing new opportunities. Leverage strong communication skills and industry knowledge to build lasting relationship...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Take ownership of comprehensive cyber risk assessments across the enterprise, articulating risks in business terms to ensure informed decision-making by leadership and helping to strengthen the organi...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Technical Services

$122K - $187K *

Lead strategic initiatives to drive sales growth and enhance customer relationships within assigned accounts, leveraging your expertise in enterprise software to exceed quotas and deliver tailored sol...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in executing Proof of Value engagements, demonstrating the Tanium platform's capabilities while collaborating with account teams to align with customer objectives and drive successful...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Innovate and develop complex applications for federal clients, collaborating with teams to ensure high-quality solutions. Utilize modern technologies and best practices to enhance user experience and...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$140K - $180K *

Lead the execution of complex IT infrastructure projects, ensuring mission success for critical U.S. Coast Guard programs. Collaborate with stakeholders and manage resources to deliver seamless techno...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$250K - $500K+*

Drive innovation by collaborating with hardware teams to enhance tools, evolve compilers, and improve developer experiences, ensuring efficient and effective hardware design processes...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$119K - $167K *

Lead the charge in evolving our cloud infrastructure and CI/CD systems. As a Senior DevOps Engineer, you'll enhance security, reliability, and operational efficiency while mentoring a team and ensurin...

United StatesRemote

Reposted 6 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Lead the charge in designing and implementing HR Service Delivery solutions, integrating Microsoft 365 with ServiceNow. Optimize employee experiences through automated workflows and seamless connectio...

RemoteRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $150K *

Elevate employee experiences by designing and implementing HR solutions. Lead technical projects, optimize integrations with Microsoft 365, and mentor developers to enhance ServiceNow capabilities and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a team that's shaping the future of embedded systems and simulation technologies. Collaborate globally to tackle complex technical challenges, enhance product reliability, and support innovative...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

$160K - $180K *

Collaborate with partners to build a robust technical foundation for channel sales. Enable engineers to independently deploy solutions, ensuring technical readiness and driving measurable success in p...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $155K *

Drive business growth by leading consulting and system studies for T&D infrastructure, focusing on data centers. Engage with industry leaders and ensure high-quality technical solutions while supporti...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Energy & Utilities

$150K - $180K *

Join a team that's driving growth in the biopharmaceutical sector by developing strategic business relationships, prospecting new clients, and leading sales initiatives to achieve organizational objec...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$180K *

Optimize cloud strategies for partners by transforming Google Cloud and AI opportunities into sustainable workloads, guiding technical and commercial discussions, and fostering repeatable practices fo...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $160K *

Optimize customer networks while delivering integrated networking and cybersecurity solutions. Collaborate globally, enhance performance, and ensure satisfaction as you tackle complex challenges in an...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$232K - $320K *

Unlock potential by leading a dynamic Solutions Consulting team to deliver innovative cybersecurity solutions. Collaborate with sales and customers to ensure value realization and drive success in pre...

RemoteRemote

5 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$110K - $130K *

Join us to shape the future of mobility by supporting microcontroller customers. Leverage your embedded software expertise to drive innovative solutions and collaborate with diverse teams, ensuring su...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$105K - $123K *

Innovate in security engineering by supporting IAM, AI, and Cloud initiatives. Leverage your IT or software development skills to enhance security practices while collaborating with senior engineers i...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$135K - $220K *

Engage with clients to transform business challenges into AI solutions. Collaborate in a multidisciplinary team to develop prototypes and integrate AI applications using AWS services, ensuring quality...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$95K - $115K *

Transform the ScriptMed Cloud Platform by designing and deploying scalable solutions. Collaborate with teams to automate workflows and enhance customer onboarding while ensuring compliance with data s...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.