Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$120K *

Lead the charge in securing AI applications by building robust defenses and controls across our core security platforms. This hands-on role involves engineering, deploying, and operating security meas...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $220K *

Unlock potential by joining a dynamic security team to enhance cloud and application security, ensuring compliance and fostering a secure culture across all functions while leveraging cutting-edge tec...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $150K *

Empower our cybersecurity initiatives by providing strategic leadership and ensuring compliance with DoD standards. Drive enterprise-level security architecture and risk management across multiple Tas...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$138K - $173K *

Drive cross-functional collaboration to ensure high-quality software delivery. Lead and mentor a team of engineers while optimizing processes and fostering a culture of innovation and continuous impro...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Lead and guide project teams in implementing GRC and cybersecurity programs, ensuring the effectiveness of IT controls and compliance frameworks while mentoring junior staff and managing client relati...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $218K *

Transform the future of aerospace engineering by leading multi-site teams, enhancing technical capabilities, and driving operational excellence to meet customer demands and improve performance across...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$65K - $150K *

Explore the forefront of AI technology, tackling complex challenges and enhancing intelligent systems. Collaborate with engineers to troubleshoot and improve performance across various platforms, shap...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$96K - $120K *

Accelerate progress at the forefront of digital banking by leading complex client implementations, resolving advanced technical issues, and ensuring successful delivery of innovative solutions that al...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $200K *

Empower mission-critical federal systems by leading the design and automation of secure cloud platforms. Drive reliability, mentor engineers, and set technical direction in a collaborative environment...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Information Technology

$113K - $188K *

Join a dynamic team to design and develop high-performance ETL solutions, integrating data from diverse sources. Collaborate with cross-functional teams to optimize data workflows and ensure complianc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$68K - $143K *

Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $183K *

Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Elevate your career by leading infrastructure systems that drive engineering and product success. This hands-on role combines technical expertise with strategic vision, ensuring reliability and scalab...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Empower seamless travel operations by managing critical systems and integrations. Collaborate with cross-functional teams to enhance performance and security of travel platforms, ensuring optimal user...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Hospitality & Recreation

$150K - $180K *

Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$159K - $210K *

Unlock potential by leading cloud security architecture and posture management across multi-subscription environments. Drive automation, establish guardrails, and collaborate with teams to ensure secu...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$145K - $175K *

Elevate your career by leading product marketing for AI governance solutions. Drive impactful narratives, engage with analysts, and create high-quality content to enhance visibility and credibility in...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$69K - $101K *

Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$145K - $175K *

Shape the future of software engineering by leading modernization efforts, solving complex technical challenges, and mentoring teams. Collaborate across product boundaries to enhance system architectu...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$250K - $300K *

Shape the future of AI-driven platforms by designing scalable applications and intelligent workflows. Lead initiatives that enhance operational efficiency and enable real-time insights, while mentorin...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$215K - $307K *

Lead the charge in designing and evolving global cloud infrastructure, leveraging deep Azure expertise to build secure, scalable systems that enhance enterprise SaaS platforms and improve developer ex...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$150K - $200K *

Transform the security landscape by leading corporate security and compliance initiatives. Own identity infrastructure, manage vendor relationships, and ensure customer trust while implementing robust...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$110K - $130K *

Transform the future of marketing by designing and deploying AI-driven growth systems. This hands-on role merges engineering and marketing to enhance customer engagement and streamline operations thro...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Energy & Utilities

$200K - $205K *

Drive the expansion of our Data Services & Analytics practice by leading technical delivery, managing client relationships, and overseeing project execution. Empower teams to deliver innovative data i...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.