Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
Locations
caret down
More
1
caret down

Sort By: Relevance

$110K - $130K *

Elevate data engineering capabilities by designing robust ETL/ELT workflows, ensuring data quality, and implementing scalable solutions on AWS and Kubernetes. Collaborate with teams to optimize perfor...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $160K *

Drive the design and management of cloud infrastructure, ensuring secure, scalable systems that align IT operations with business goals. Lead initiatives in automation and DevSecOps to enhance operati...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $90K *

Transform the IT landscape by enhancing cloud services and user systems. Play a key role in optimizing platforms like Azure, O365, and Jira, while driving efficiencies through automation and collabora...

RemoteRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$140K - $160K *

Elevate your career by joining a dynamic team as a Data Engineer, owning end-to-end data systems and driving platform modernization. You'll improve data reliability and work closely with cross-functio...

United StatesRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $180K *

Elevate customer success by managing strategic federal programs, ensuring seamless implementation and adoption of innovative solutions. Collaborate with stakeholders to drive project execution and enh...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$225K - $305K *

Create a robust security compliance program that ensures customer trust and regulatory readiness. Lead a global team, design controls, manage audits, and integrate AI-driven solutions to address diver...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Enterprise Technology

$238K - $280K *

Shape the future of AI/LLM security by leading innovative offensive strategies, defining technical vision, and driving cross-company initiatives to enhance NodeZero's capabilities in identifying and e...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $170K *

Lead the evolution of our design system by building accessible, reusable components and collaborating with cross-functional teams to enhance user experiences and streamline adoption across products...

United StatesRemote

1 month ago

  •   Less than 5 years exp.  •   Finance & Insurance

$138K - $184K *

Lead the design and execution of electrical systems for mission critical facilities, collaborating with teams to ensure high availability and efficiency. Oversee projects from concept to construction...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Technical Services

$130K - $160K *

Elevate cloud security and reliability by leading DevOps practices across teams. You'll optimize AWS and GCP environments, enhance CI/CD pipelines, and ensure cost-effective engineering tools, driving...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Legal & Accounting

$200K - $383K *

Join us to lead the contracts function in a dynamic Federal contracting environment. Oversee a team of 20+ professionals, develop strategies, and negotiate complex contracts while fostering strong rel...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Real Estate & Construction

$104K - $156K *

Join us to architect innovative financial systems, leading greenfield projects that enhance data management and analytics. Collaborate across teams to implement your vision and drive impactful solutio...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$261K - $356K *

Join a team that's driving enterprise growth by modernizing networking and security for cloud-native environments. Build executive relationships and engage technical stakeholders to exceed sales targe...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$115K - $151K *

Administer and enhance collaboration platforms, ensuring seamless integration and automation across teams. Collaborate with cross-functional departments to optimize workflows and improve operational e...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Join a dynamic team to design and optimize data pipelines, ensuring quality and security for analytics and AI capabilities. Collaborate with cross-functional teams to deliver innovative data solutions...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$170K - $220K *

Accelerate your career by driving sales growth through strategic partnerships and innovative solutions in the cloud computing space. Collaborate with teams to achieve targets and enhance customer sati...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$133K - $209K *

Join a dynamic IT team as you safeguard cloud infrastructure, enhance security measures, and lead incident response efforts. Your expertise will drive continuous improvement and ensure robust protecti...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive logistics optimization and cost reduction initiatives across global service operations, enhancing efficiency and performance in transportation and network design while collaborating with cross-f...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$140K - $187K *

Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$180K - $200K *

Reimagine security engineering leadership by guiding strategic initiatives across cloud and infrastructure security, enhancing detection engineering, and fostering collaboration to protect a multi-clo...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$120K - $145K *

Help us secure our cloud-based healthcare platforms by designing and implementing robust security solutions. This role demands expertise in cloud security, AI/ML protection, and compliance with indust...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Build innovative AI solutions by collaborating with clients to tackle complex challenges. Design and deploy production-quality software while ensuring reliability and usability in real-world environme...

United StatesRemote

Reposted 5 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$85K - $95K *

Collaborate with a dynamic team as a Structural BIM Technician to create detailed models, streamline design processes, and enhance interoperability in building projects, while upholding high-quality s...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$150K - $180K *

Innovate solutions as a Global Resolution Engineer, tackling complex escalations across diverse customer environments. Collaborate with teams to enhance product reliability and drive proactive improve...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $145K *

Lead the charge in building impactful software features that enhance educators' management of English Learner programs, taking ownership from design to operation in a full-stack environment utilizing...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.