Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$120K - $145K *

Lead the charge in securing enterprise applications by conducting thorough penetration tests, validating vulnerabilities, and collaborating with engineering teams to enhance security measures across d...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$466K - $500K+*

Elevate your career by building a cutting-edge ML data platform that enhances productivity for ML practitioners. Collaborate with experts to create innovative solutions for feature computation and sha...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Hospitality & Recreation

$209K - $275K *

Elevate your career by leading and developing a high-performing Solutions Engineering team. Drive strategic alignment across functions, foster technical excellence, and implement innovative practices...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$90K - $110K *

Help us drive project success by managing AV integration projects from inception to completion, ensuring timely delivery, budget adherence, and client satisfaction while fostering collaboration within...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Media

$95K - $125K *

Drive the deployment of healthcare technology across multiple VA facilities, coordinating projects and ensuring readiness. Collaborate with diverse teams to manage timelines, resolve issues, and deliv...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$85K - $111K *

Lead cross-functional teams to design and implement resilient infrastructure solutions. Collaborate with diverse stakeholders to ensure timely delivery of high-quality systems, leveraging automation a...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Business Services

$170K - $200K *

Join a dynamic team to design and implement scalable data pipelines, transforming diverse data sources into actionable insights. Collaborate with cross-functional experts to drive innovation and maint...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Accelerate growth by driving AI adoption in legal teams. You'll convert inbound leads and build outbound strategies to tap into a vast market, managing demos, trials, and closing deals while collabora...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$150K - $175K *

Lead the charge in architecting and managing robust cloud platforms, driving modernization efforts, and automating infrastructure solutions for large-scale enterprises. Collaborate with top engineers...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $170K *

Join a dynamic team driving AI innovation by guiding organizations in adopting Microsoft Copilot and Power Platform. Leverage your technical expertise and strategic insights to enhance productivity an...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Shape the future of creative leadership by setting visionary strategies, driving distinctive brand expressions, and empowering a talented team to deliver integrated, high-impact marketing campaigns th...

United StatesRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$98K - $155K *

Unlock potential by enhancing cloud communication systems, optimizing architectures, and leading AI integrations. Thrive in a dynamic environment while mentoring teams and resolving complex issues acr...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$154K - $225K *

Pioneer innovation in enterprise wireless solutions by leveraging expertise in Wi-Fi standards, technical marketing, and compelling content creation. Collaborate with teams to engage top-tier customer...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$150K - $240K *

Drive the development and deployment of AI solutions, collaborating with customers to enhance workflows and deliver measurable outcomes across various industries. Engage in hands-on engineering from p...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$130K - $155K *

Join a dynamic team as a key partner in revenue operations, collaborating with sales leadership to drive growth, manage forecasting, and enhance business strategies across multiple units. Embrace inno...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$108K - $130K *

Unlock potential by leading the development of AI-driven test automation frameworks for cloud migration, ensuring seamless transitions for enterprise imaging customers while collaborating with enginee...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$115K - $138K *

Manage complex data center deployment projects, ensuring timely delivery and alignment among stakeholders. Oversee planning, execution, and closeout while maintaining budget and risk controls in fast...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$110K - $130K *

Advance mechanical systems readiness by overseeing commissioning, conducting site inspections, and ensuring operational efficiency across critical infrastructure. Collaborate cross-functionally to enh...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$103K - $181K *

Shape the future of secure software by developing full-stack applications that support critical government missions. Collaborate with diverse teams to deliver reliable, scalable solutions in dynamic e...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$90K - $110K *

Unlock your potential by designing advanced PCB layouts and collaborating on innovative RF designs. This remote role requires expertise in Altium and a strong understanding of PCB standards to drive q...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$160K - $200K *

Lead the charge in defining and executing security architecture strategies, focusing on identity, access, and Zero Trust initiatives. Collaborate across teams to enhance security posture while enablin...

RemoteRemote

6 days ago

  •   8 - 10 years exp.  •   Media

$63K - $111K *

Join a team that's dedicated to enhancing security systems globally. As a Senior Security Technician, you'll install, maintain, and troubleshoot advanced security solutions while mentoring junior staf...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$190K - $215K *

Engage in the design and development of robust full-stack solutions, guiding teams in secure engineering practices while integrating innovative technologies in a federal environment. Drive impactful c...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$170K - $230K *

Engineer the future of edge-AI by converting customer evaluations into design wins. Collaborate with engineering teams to optimize workloads on our innovative Chimera architecture, shaping the next ge...

RemoteRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$92K - $153K *

Drive the design and implementation of security controls in AWS cloud environments, ensuring compliance with security frameworks while collaborating with engineering teams to enhance secure CI/CD proc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Business Services

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.