Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$104K - $155K *

Lead the charge in customer-focused project management, ensuring effective delivery of technical solutions while coordinating with diverse stakeholders and fostering strong relationships for successfu...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$100K - $120K *

Shape the future of startups by driving high-impact initiatives across multiple portfolio companies. Engage directly with founders to tackle critical challenges, scale operations, and explore new busi...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Enterprise Technology

$83K - $104K *

Join a team that's driving strategic marketing initiatives and influencing success. Collaborate with leaders to develop compelling narratives and innovative strategies that elevate project pursuits an...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$95K - $115K *

Empower your career by bridging sales and engineering as a key technical resource. You'll scope, quote, and support customer needs for low and medium-voltage switchgear solutions, ensuring alignment w...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Join a dynamic team to build and optimize healthcare data pipelines, ensuring data quality and compliance while supporting a statewide Health Information Exchange and Health Data Utility initiatives...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Champion the development of healthcare data pipelines and quality assurance processes. Play a key role in supporting a statewide Health Information Exchange while ensuring data integrity and complianc...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Transform healthcare data management by building robust data pipelines and ensuring data quality. Collaborate with clinical teams to optimize data workflows and enhance the Health Information Exchange...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by building and optimizing healthcare data pipelines, ensuring data quality and compliance within a remote team dedicated to enhancing health information exchange and utility operatio...

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Drive technical solutions as a client-facing architect, leveraging deep expertise in JavaScript, TypeScript, and Python to guide enterprise-level projects across multiple cloud environments and enhanc...

United StatesRemote

Reposted 5 days ago

  •   8 - 10 years exp.  •   Information Technology

$76K - $142K *

Elevate your career by driving engineering excellence and process improvements. Lead initiatives in quality assurance, failure analysis, and supplier management while applying Lean Six Sigma methodolo...

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$135K - $160K *

Shape the future of networking by designing and implementing advanced SDN orchestration systems for high-performance, isolated networking in distributed computing environments, enabling seamless acces...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$207K - $366K *

Lead strategic account management initiatives, driving growth and client satisfaction through innovative solutions and cross-functional collaboration. Shape the future of client relationships by ensur...

United StatesRemote

6 days ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $150K *

Innovate as you guide Fortune 500 clients in leveraging AI solutions. Collaborate with sales teams, deliver dynamic presentations, and serve as trusted technical advisor to modernize legacy systems an...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$77K - $108K *

Drive the implementation and support of AI workload orchestration platforms, ensuring high-quality technical outcomes in client environments. Collaborate across teams to deliver reliable, secure acces...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Join a dynamic team to architect and implement a next-gen Design System, ensuring consistent, accessible experiences across products. Collaborate with cross-functional teams to drive technical alignme...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Food & Beverages

$140K - $175K *

Lead the charge in building trust through compliance frameworks, guiding customers and teams in navigating security and data protection. Engage directly with clients, translating complex compliance ne...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Deliver impactful IT solutions by owning and enhancing infrastructure, systems, and processes that ensure operational integrity and security while collaborating with teams to meet business needs as th...

RemoteRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Champion the design and delivery of modern data platforms, focusing on Microsoft Fabric and Azure. Lead client engagements, define architectures, and establish best practices for data solutions across...

RemoteRemote

Reposted 2 days ago

  •   8 - 10 years exp.  •   Information Technology

$193K - $230K *

Contribute to the growth of Air Traffic Control solutions by developing strategic customer relationships, identifying new business opportunities, and managing the sales cycle to enhance market presenc...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$164K - $229K *

Elevate infrastructure reliability and performance by architecting scalable solutions, collaborating across teams, and driving end-to-end software delivery to enhance user experience and system resili...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Media

$90K - $110K *

Transform the future of mobile broadcasting by leading technical operations, ensuring show readiness, and delivering exceptional live production experiences while mentoring teams and managing client r...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Media

$77K - $95K *

Optimize cloud operations by managing and enhancing cloud compute systems. Collaborate with teams to ensure efficient capacity planning, alert monitoring, and customer support, while driving continuou...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$150K - $180K *

Champion the evolution of our billing systems by leading a dynamic engineering team. Drive strategy, ensure accuracy, and collaborate across departments to enhance customer trust as we scale our usage...

RemoteRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$89K - $105K *

Lead the charge in enhancing customer trust through security assurance and AI governance. This role focuses on maintaining accurate security documentation and optimizing AI agents to support governanc...

United StatesRemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Information Technology

$114K - $145K *

Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.