Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.
High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.
Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.
Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.
$104K - $155K *
Lead the charge in customer-focused project management, ensuring effective delivery of technical solutions while coordinating with diverse stakeholders and fostering strong relationships for successfu...
Reposted 1 week ago
Generalist Builder-in-Residence
$100K - $120K *
Shape the future of startups by driving high-impact initiatives across multiple portfolio companies. Engage directly with founders to tackle critical challenges, scale operations, and explore new busi...
Reposted today
$83K - $104K *
Join a team that's driving strategic marketing initiatives and influencing success. Collaborate with leaders to develop compelling narratives and innovative strategies that elevate project pursuits an...
1 week ago
Application Engineer (Switchgear)
$95K - $115K *
Empower your career by bridging sales and engineering as a key technical resource. You'll scope, quote, and support customer needs for low and medium-voltage switchgear solutions, ensuring alignment w...
3 weeks ago
$95K - $115K *
Join a dynamic team to build and optimize healthcare data pipelines, ensuring data quality and compliance while supporting a statewide Health Information Exchange and Health Data Utility initiatives...
1 week ago
$95K - $115K *
Champion the development of healthcare data pipelines and quality assurance processes. Play a key role in supporting a statewide Health Information Exchange while ensuring data integrity and complianc...
1 week ago
$95K - $115K *
Transform healthcare data management by building robust data pipelines and ensuring data quality. Collaborate with clinical teams to optimize data workflows and enhance the Health Information Exchange...
1 week ago
$95K - $115K *
Unlock potential by building and optimizing healthcare data pipelines, ensuring data quality and compliance within a remote team dedicated to enhancing health information exchange and utility operatio...
1 week ago
Solutions Architect (Pre-Sales & Delivery) - Remote - USA
$125K - $150K *
Drive technical solutions as a client-facing architect, leveraging deep expertise in JavaScript, TypeScript, and Python to guide enterprise-level projects across multiple cloud environments and enhanc...
Reposted 5 days ago
Operations Engineer Senior - Level 3
$76K - $142K *
Elevate your career by driving engineering excellence and process improvements. Lead initiatives in quality assurance, failure analysis, and supplier management while applying Lean Six Sigma methodolo...
3 weeks ago
Senior Software Engineer, Network Platform
$135K - $160K *
Shape the future of networking by designing and implementing advanced SDN orchestration systems for high-performance, isolated networking in distributed computing environments, enabling seamless acces...
6 days ago
$207K - $366K *
Lead strategic account management initiatives, driving growth and client satisfaction through innovative solutions and cross-functional collaboration. Shape the future of client relationships by ensur...
6 days ago
$120K - $150K *
Innovate as you guide Fortune 500 clients in leveraging AI solutions. Collaborate with sales teams, deliver dynamic presentations, and serve as trusted technical advisor to modernize legacy systems an...
Reposted 2 weeks ago
AI Infrastructure Consulting Engineer - Orchestration & Platform
$77K - $108K *
Drive the implementation and support of AI workload orchestration platforms, ensuring high-quality technical outcomes in client environments. Collaborate across teams to deliver reliable, secure acces...
1 week ago
Senior Staff Engineer, Design Systems
$135K - $160K *
Join a dynamic team to architect and implement a next-gen Design System, ensuring consistent, accessible experiences across products. Collaborate with cross-functional teams to drive technical alignme...
1 week ago
Security-Compliance Program Manager
$140K - $175K *
Lead the charge in building trust through compliance frameworks, guiding customers and teams in navigating security and data protection. Engage directly with clients, translating complex compliance ne...
4 weeks ago
$80K - $95K *
Deliver impactful IT solutions by owning and enhancing infrastructure, systems, and processes that ensure operational integrity and security while collaborating with teams to meet business needs as th...
Reposted 3 days ago
$135K - $160K *
Champion the design and delivery of modern data platforms, focusing on Microsoft Fabric and Azure. Lead client engagements, define architectures, and establish best practices for data solutions across...
Reposted 2 days ago
Business Development Manager/Account Manager - Air Traffic Control Systems
$193K - $230K *
Contribute to the growth of Air Traffic Control solutions by developing strategic customer relationships, identifying new business opportunities, and managing the sales cycle to enhance market presenc...
2 days ago
Software Engineer, Infrastructure Engineering
$164K - $229K *
Elevate infrastructure reliability and performance by architecting scalable solutions, collaborating across teams, and driving end-to-end software delivery to enhance user experience and system resili...
Reposted today
$90K - $110K *
Transform the future of mobile broadcasting by leading technical operations, ensuring show readiness, and delivering exceptional live production experiences while mentoring teams and managing client r...
1 week ago
$77K - $95K *
Optimize cloud operations by managing and enhancing cloud compute systems. Collaborate with teams to ensure efficient capacity planning, alert monitoring, and customer support, while driving continuou...
Yesterday
Software Engineering Manager, Billing
$150K - $180K *
Champion the evolution of our billing systems by leading a dynamic engineering team. Drive strategy, ensure accuracy, and collaborate across departments to enhance customer trust as we scale our usage...
2 weeks ago
Security Analyst (Governance and Trust)
$89K - $105K *
Lead the charge in enhancing customer trust through security assurance and AI governance. This role focuses on maintaining accurate security documentation and optimizing AI agents to support governanc...
Reposted 6 days ago
$114K - $145K *
Unlock your potential as a Data Engineer, transforming raw data into impactful systems. Collaborate with stakeholders, optimize data architecture, and drive efficiency through automation while managin...
6 days ago
What types of $100,000+ jobs can I find in Mississippi?
Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.
Which Mississippi cities have high-paying job opportunities?
Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.
Are remote jobs available to Mississippi residents?
Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.
How can I qualify for a $100,000+ job in Mississippi?
Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.