Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$125K - $150K *

Empower customer success by designing impactful journeys that drive retention and revenue. Lead cross-functional teams to create and optimize service blueprints, ensuring seamless customer experiences...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$135K - $180K *

Drive innovative electrical design solutions for high-density compute environments. Collaborate across teams to ensure compliance with industry standards while mentoring junior engineers. Make a signi...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $113K *

Take ownership of contract administration for government and commercial agreements. Collaborate cross-functionally to ensure compliance, manage risks, and drive process improvements while supporting t...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $225K *

Drive successful customer engagements by managing technical sales processes, designing enterprise-level solutions, and building strong relationships to close deals. Leverage your expertise to enhance...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$125K - $150K *

Drive your career with innovative AI-driven automation solutions that enhance IT operations and user experience. Collaborate across teams to minimize manual tasks, improve efficiency, and implement in...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$183K - $200K *

Shape the future of offensive security by leading advanced penetration testing, red-team engagements, and AI-assisted workflows. Collaborate with cross-functional teams to enhance security measures an...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$96K - $130K *

Join a dynamic team to shape innovative fundraising tools that empower progressive campaigns and nonprofits. Leverage modern technologies to enhance election readiness and compliance, while mentoring...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $200K *

Drive strategic partnerships and optimize alliances to enhance revenue growth. Lead co-sell initiatives and ensure seamless partner engagement, leveraging data insights to maximize impact in AI and cl...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Empower your career as a Platform Engineer, driving innovation in system architecture and cloud technologies. Collaborate with cross-functional teams to enhance platform efficiency and guide junior en...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$151K - $178K *

Shape the future of compliance and trust in software security. Lead external examinations, manage customer diligence, and oversee third-party risk operations while mentoring a growing team dedicated t...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Transform customer experiences by architecting and delivering innovative Service Portal and AI solutions. Lead technical design and implementation, ensuring reliable software that meets business needs...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$80K - $95K *

Optimize data management processes for large government acquisitions, ensuring effective communication between teams and shipyards. Lead document management, maintain schedules, and enhance data quali...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$100K - $130K *

Champion global expansion initiatives by managing the FedRAMP program. Collaborate with cross-functional teams to ensure project timelines and deliverables are met while navigating a fast-paced enviro...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $178K *

Accelerate progress at the forefront of cloud security governance, leading a dynamic team to enhance compliance, drive automation, and ensure robust risk management across multi-cloud environments...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Healthcare

$135K - $160K *

Transform product security by leading strategy, conducting threat modeling, and collaborating across teams to ensure secure design and compliance. Drive innovation in security practices while mentorin...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Elevate security practices by building and managing a comprehensive security program. Collaborate with engineers to identify vulnerabilities, implement automated checks, and ensure robust protection a...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$140K - $180K *

Transform cancer care by developing AI biomarkers through collaboration with ML scientists and clinical partners, enhancing model robustness and interpretability across diverse datasets to improve pat...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$150K - $180K *

Architect scalable Generative AI solutions using AWS tools, focusing on LLMs, RAG, and agent-based workflows. Collaborate with teams to ensure performance and cost efficiency while guiding implementat...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $184K *

Pioneer the development and operational convergence through automation, designing CI/CD pipelines and driving release process efficiency to enhance software delivery across diverse teams and projects...

RemoteRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Information Technology

$68K - $143K *

Join us to enhance business processes through analysis and reengineering, collaborating with stakeholders to ensure effective solutions and implementation. Drive efficiency and innovation in transport...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $155K *

Join our dynamic team as a Senior Solutions Engineer, where you'll leverage your technical expertise to drive pre-sales activities, engage with clients, and deliver tailored solutions that enhance bus...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $137K *

Unlock your potential as you drive secure automation for cloud migrations, developing infrastructure as code and CI/CD pipelines. Collaborate with teams to enhance processes and ensure compliance whil...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to enhancing housing standards through comprehensive inspections and evaluations of federally subsidized properties, ensuring compliance with safety regulations and improv...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Transportation

$103K - $154K *

Innovate and lead technical solutions for utility challenges, driving strategic growth through effective pre-sales engagement and deep collaboration with clients and internal teams to deliver tailored...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$160K - $230K *

Join a team that's redefining product engineering by owning high-impact areas from concept to launch. Collaborate closely with leadership to enhance user experiences and drive innovation in a fast-pac...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.