Explore $100K+ Jobs in Mississippi

Discover professional opportunities in Mississippi with salaries of $100,000 or more. Ladders features vetted roles for experienced candidates seeking senior-level careers across the Magnolia State, from Jackson and the Gulf Coast to regional business hubs.

Mississippi Careers Across Industries

High-paying opportunities may be available in healthcare, technology, manufacturing, finance, energy, engineering, and executive leadership. Job availability and requirements vary by employer, location, and experience level, so review each listing for details.

Find Opportunities by Location

Search roles in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other Mississippi communities. You can also consider remote and hybrid positions with employers hiring professionals based in the state.

How to Search Mississippi Jobs on Ladders

Explore current listings, compare responsibilities and compensation details, and focus your search on roles that match your skills and career goals. Tailor your résumé to highlight measurable results, leadership experience, and relevant expertise when applying.

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$98K - $206K *

Elevate your career by developing and maintaining cloud infrastructure for a critical Department of the Air Force project. Collaborate with experts to enhance security and efficiency in an Azure envir...

United StatesRemote

3 days ago

  •   11 - 15 years exp.  •   Information Technology

$84K - $124K *

Drive the evolution of Cyber Defense by engineering and automating security operations, enhancing incident response, and maintaining enterprise security platforms to ensure robust protection and swift...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$165K - $228K *

Engage with customers to shape the future of Hyperscale Data Center networks. Lead architecture discussions, drive technology roadmaps, and collaborate with teams to deliver scalable, high-performance...

RemoteRemote

4 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$170K - $240K *

Lead the charge in shaping data architecture strategies, driving innovation across platforms, and mentoring teams to optimize data governance and AI integration for scalable solutions that deliver mea...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$240K - $300K *

Empower strategic partnerships across the Eastern U.S. to drive revenue growth. Build and manage a partner-sourced pipeline, enhance customer engagement, and accelerate deal closures through collabora...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$139K - $151K *

Join a team that's pushing the boundaries of advanced technologies. Lead initiatives in network infrastructure, implementing and troubleshooting solutions that support critical missions across various...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$91K - $161K *

Join a team that's shaping the future of cloud IT by designing secure, scalable systems. Collaborate across the organization to implement innovative solutions and drive operational excellence, leverag...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Join a team that's redefining application security by guiding customers through complex evaluations. Leverage your expertise in offensive security to build relationships, deliver impactful demos, and...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Optimize your career as an Infor M3 Technical Consultant, leveraging 3-5 years of expertise in integrations and development. Collaborate with teams to design and support seamless enterprise solutions...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$172K - $210K *

Architect and lead customer-focused application development initiatives, translating business needs into robust software solutions. Leverage modern technologies and AI tools to ensure high-quality, se...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$135K - $238K *

Elevate customer experiences by designing and developing cutting-edge AI-driven bot applications. Collaborate with teams to deliver innovative solutions, manage strategic projects, and leverage advanc...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$143K - $214K *

Oversee and enhance security measures across network, compliance, and access management. Collaborate with teams to design and implement resilient infrastructure while leading a high-performing securit...

United StatesRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$320K - $488K *

Partner with us to lead developer relations in quantum computing, driving adoption of innovative SDKs. Collaborate across federal programs as a strategic bridge to elevate scientific research and tech...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$170K - $250K *

Help us build a high-performing infrastructure team that drives operational excellence and reliability. Lead a diverse group of engineers, manage budgets, and modernize technology while collaborating...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Lead the charge in designing scalable, cloud-based SaaS solutions for Higher Education. Collaborate with cross-functional teams to translate institutional needs into actionable solutions, ensuring ali...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$117K - $147K *

Empower multi-site data center and AI infrastructure programs valued at $25M+, leading diverse teams to ensure successful delivery, budget management, and customer satisfaction while driving executive...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$250K - $500K+*

Optimize and innovate software kernels for hardware integration, collaborating with ML Research and Hardware Engineering teams to enhance performance and efficiency in cutting-edge technology applicat...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$139K - $232K *

Unlock potential by providing enterprise architecture leadership for Corporate Functions, focusing on Finance and supporting areas. Shape technology strategies and roadmaps to enhance financial manage...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$100K - $120K *

Lead the charge in enhancing fire protection systems for nuclear facilities while collaborating with engineering teams, ensuring compliance with regulations, and supporting modifications that safeguar...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Energy & Utilities

$90K - $100K *

Join a dynamic team as you craft precise architectural specifications, collaborating with architects to ensure high-quality project documentation and stay ahead of industry trends. Elevate your career...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$138K - $207K *

Elevate customer success by leading technical onboarding and implementation efforts. Collaborate cross-functionally to drive adoption and ensure timely value delivery in a fast-paced AI security envir...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$138K - $207K *

Help us drive customer success by leading technical onboarding and implementation efforts, ensuring seamless post-sales support, and collaborating cross-functionally to enhance the customer journey in...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$152K - $228K *

Help us drive customer success by leading technical onboarding and implementation efforts. Collaborate cross-functionally to ensure seamless post-sales support and foster long-term partnerships in a f...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$77K - $118K *

Transform network operations by designing and implementing automation solutions that enhance reliability and efficiency across multi-vendor infrastructures, utilizing advanced technologies like Python...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $130K *

Transform the contracting process by managing the lifecycle of agreements, ensuring efficient execution while balancing risk and compliance. Collaborate with cross-functional teams to support business...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What types of $100,000+ jobs can I find in Mississippi?question toggle

    Listings may include senior roles in healthcare, technology, manufacturing, finance, energy, engineering, and management. Opportunities change over time, so check current listings for available positions.

  • Which Mississippi cities have high-paying job opportunities?question toggle

    Professional opportunities may be listed in Jackson, Gulfport, Biloxi, Hattiesburg, Southaven, and other parts of the state, depending on employer hiring needs.

  • Are remote jobs available to Mississippi residents?question toggle

    Some employers offer remote or hybrid positions that may be open to Mississippi-based candidates. Review each listing to confirm location and work arrangement requirements.

  • How can I qualify for a $100,000+ job in Mississippi?question toggle

    Requirements vary by role. Employers commonly seek relevant experience, specialized skills, and a record of strong results; senior positions may also require leadership experience or advanced credentials.