Explore $100K+ Jobs in Iowa

Find professional opportunities across Iowa with salaries of $100,000 or more. From Des Moines and Cedar Rapids to Iowa City, Davenport, and beyond, Ladders helps experienced professionals discover vetted roles that match their skills and career goals.

High-Paying Careers Across Iowa

Iowa employers hire experienced professionals in fields such as healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Available positions and compensation vary by employer, location, and experience, so explore listings to see which opportunities fit your background.

Where to Find Iowa Opportunities

Search jobs in major employment centers including Des Moines, Cedar Rapids, Iowa City, Davenport, and Sioux City, as well as remote and hybrid roles that may be available to candidates in Iowa. Use location and job-title filters to focus your search.

Find a Role That Fits Your Experience

Compare responsibilities, qualifications, and compensation details across openings. Keep your resume current, tailor applications to each position, and set up job alerts to stay informed when relevant high-paying jobs are posted.

Search Vetted Professional Jobs on Ladders

Ladders focuses on professional opportunities paying $100,000 or more. Browse Iowa listings to find your next career move and connect with roles suited to your expertise.

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$114K - $171K *

Join a dynamic team as a technical leader, guiding software development while mentoring talent. Drive innovation in web applications using modern frameworks, enhance team performance, and collaborate...

RemoteRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $220K *

Unlock potential by joining a dynamic security team to enhance cloud and application security, ensuring compliance and fostering a secure culture across all functions while leveraging cutting-edge tec...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$124K - $187K *

Shape your career by leading the design and operation of AI and ML systems. Collaborate across teams to establish architecture standards, optimize workflows, and ensure operational readiness for innov...

United StatesRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$140K - $210K *

Lead the charge in delivering innovative integration solutions for clients in the State & Local Government sector. Collaborate with project teams to design, develop, and implement effective Workday in...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Consumer Technology

$120K *

Lead the charge in securing AI applications by building robust defenses and controls across our core security platforms. This hands-on role involves engineering, deploying, and operating security meas...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Healthcare

$130K - $150K *

Empower our cybersecurity initiatives by providing strategic leadership and ensuring compliance with DoD standards. Drive enterprise-level security architecture and risk management across multiple Tas...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$138K - $173K *

Drive cross-functional collaboration to ensure high-quality software delivery. Lead and mentor a team of engineers while optimizing processes and fostering a culture of innovation and continuous impro...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$150K - $180K *

Grow enterprise SAP relationships by managing key accounts and driving new business. Leverage your expertise to expand client portfolios, develop strategic plans, and ensure client satisfaction while...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Lead and guide project teams in implementing GRC and cybersecurity programs, ensuring the effectiveness of IT controls and compliance frameworks while mentoring junior staff and managing client relati...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$65K - $150K *

Explore the forefront of AI technology, tackling complex challenges and enhancing intelligent systems. Collaborate with engineers to troubleshoot and improve performance across various platforms, shap...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$70K - $100K *

Oversee and manage construction projects, ensuring budget adherence, timely completion, and customer satisfaction while leading a dedicated project team and maintaining effective communication with st...

3 weeks ago

  •   8 - 10 years exp.  •   Transportation

$140K - $200K *

Empower mission-critical federal systems by leading the design and automation of secure cloud platforms. Drive reliability, mentor engineers, and set technical direction in a collaborative environment...

United StatesRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$96K - $120K *

Accelerate progress at the forefront of digital banking by leading complex client implementations, resolving advanced technical issues, and ensuring successful delivery of innovative solutions that al...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $218K *

Transform the future of aerospace engineering by leading multi-site teams, enhancing technical capabilities, and driving operational excellence to meet customer demands and improve performance across...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$80K - $95K *

Shape the future of product design by developing innovative solutions from concept to production. Collaborate with cross-functional teams to ensure designs meet safety and quality standards while ment...

Reposted 5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$150K - $180K *

Elevate your career by leading infrastructure systems that drive engineering and product success. This hands-on role combines technical expertise with strategic vision, ensuring reliability and scalab...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead the charge in driving operational excellence through innovative improvements, leveraging Lean and Six Sigma methodologies to enhance manufacturing efficiency, reduce waste, and optimize processes...

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$113K - $188K *

Join a dynamic team to design and develop high-performance ETL solutions, integrating data from diverse sources. Collaborate with cross-functional teams to optimize data workflows and ensure complianc...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$150K - $180K *

Pioneer the strategy and execution of data platforms and AI products, leading cross-functional teams to enhance commercial life sciences solutions while driving revenue growth and product adoption in...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$80K - $95K *

Empower seamless travel operations by managing critical systems and integrations. Collaborate with cross-functional teams to enhance performance and security of travel platforms, ensuring optimal user...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$68K - $143K *

Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $183K *

Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$159K - $210K *

Unlock potential by leading cloud security architecture and posture management across multi-subscription environments. Drive automation, establish guardrails, and collaborate with teams to ensure secu...

United StatesRemote

2 days ago

  •   11 - 15 years exp.  •   Healthcare

$150K - $200K *

Transform the security landscape by leading corporate security and compliance initiatives. Own identity infrastructure, manage vendor relationships, and ensure customer trust while implementing robust...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Energy & Utilities

$69K - $101K *

Champion the reliability of automated systems by providing expert technical support, troubleshooting complex issues, and collaborating cross-functionally to ensure operational excellence and seamless...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

Frequently Asked Questions (FAQ)

  • What kinds of $100,000+ jobs are available in Iowa?question toggle

    Listings may include opportunities in healthcare, technology, finance, engineering, manufacturing, insurance, and business leadership. Roles and salary ranges vary by employer and experience.

  • Which Iowa cities have professional jobs listed?question toggle

    Explore opportunities in Des Moines, Cedar Rapids, Iowa City, Davenport, Sioux City, and other Iowa locations. Remote or hybrid openings may also be available.

  • Are all jobs on this page guaranteed to pay at least $100,000?question toggle

    Ladders focuses on professional jobs paying $100,000 or more, but compensation and eligibility can vary. Review each listing for its specific salary information and requirements.

  • How can I find the right high-paying job in Iowa?question toggle

    Use filters for location, job title, and other preferences, then compare responsibilities and qualifications. Keeping your resume updated and setting job alerts can help you respond to relevant openings.