Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$120K - $150K *

Lead vendor security engagements by assessing risks, developing solutions, and ensuring compliance. Collaborate with cross-functional teams to enhance security practices and drive implementation of ef...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Lead and enhance our analytics efforts by managing a skilled team while driving the implementation of business intelligence solutions to optimize Epic EHR usability and performance across diverse appl...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$86K - $165K *

Elevate your career by driving supply chain strategies and supplier management in a dynamic, remote role. Collaborate with cross-functional teams to achieve program objectives and enhance operational...

California, USRemote

Reposted today

  •   5 - 7 years exp.  •   Aerospace & Defense

$131K - $237K *

Optimize multi-cloud architectures and lead technical initiatives to enhance application performance, security, and cost-efficiency. Collaborate with cross-functional teams to modernize systems and en...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Technical Services

$125K - $150K *

Architect robust AI infrastructure to detect and mitigate emerging threats. Drive innovation in data ingestion and model tuning while managing complex pipelines in a high-stakes environment that evolv...

RemoteRemote

1 month ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Unlock potential by driving sales strategies for net-new logo acquisition. Own the full sales cycle, engage diverse stakeholders, and navigate complex procurement paths to achieve revenue targets and...

Raleigh, NCRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Accelerate progress at the forefront of technology sales, driving net-new acquisitions and managing complex sales cycles. Engage diverse stakeholders and deliver impactful presentations, all while nav...

Jersey City, NJRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $110K *

Grow your career with a pivotal role in configuration management, ensuring system stability and compliance. Collaborate across teams to track changes, maintain documentation, and support deployments i...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$94K - $164K *

Champion technical delivery and governance for enterprise release management, ensuring reliable software deployment and continuous improvement across teams while driving AI adoption and enhancing oper...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Healthcare

$105K - $125K *

Drive impactful disaster recovery efforts by overseeing construction projects, ensuring compliance with regulations, and leading quality control initiatives. Collaborate with teams to enhance communit...

Florida, USRemote

2 days ago

  •   5 - 7 years exp.  •   Business Services

$69K - $158K *

Accelerate progress at the intersection of imaging and AI by developing advanced processing tools for remote sensing challenges, driving mission outcomes through collaborative software solutions...

Dayton, OHRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Transform project delivery by managing multiple building systems initiatives, ensuring that projects align with company standards, budget constraints, and critical timelines. Serve as a key liaison am...

Dallas, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead strategic cybersecurity initiatives, enhance client security posture, and manage complex incident responses. Collaborate with teams to develop solutions, analyze threats, and improve security ope...

Massachusetts, USRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $125K *

Advance your career by ensuring optimal database performance and security. Collaborate with cross-functional teams to implement robust architecture, perform upgrades, and support database applications...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Retail & Consumer Goods

$113K - $139K *

Unlock potential by designing and developing advanced data models and ETL specifications. Collaborate on system architecture and standards to enhance data solutions in a dynamic environment, while coo...

Oregon, USRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$120K - $193K *

Drive innovation by leading teams to build and operate data products and AI solutions that enhance risk and compliance decision-making, ensuring scalable, reliable, and responsible implementations wit...

Illinois, USRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$63K - $111K *

Empower mission success by assessing utility vulnerabilities and enhancing infrastructure resilience against diverse threats. Collaborate with a multidisciplinary team to ensure operational continuity...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $150K *

Optimize subcontractor risk management by overseeing prequalification, analyzing financial statements, and enhancing the SDI program. Collaborate with operations to ensure compliance and support proje...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $147K *

Oversee project financial performance and analytics, ensuring effective management across complex contracts. Collaborate with teams to enhance processes and deliver actionable insights, driving operat...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$131K - $196K *

Architect and lead the commissioning process for cutting-edge liquid-cooled and AI factory deployments. Ensure rigorous testing and validation, providing independent assurance on performance and desig...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $150K *

Lead the development and implementation of a comprehensive safety program for a federal construction project, ensuring compliance with regulations and fostering a proactive safety culture through trai...

Alexandria, VARemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$125K - $213K *

Drive innovative solutions as a Business Systems Analyst, leading complex initiatives that enhance business and technology outcomes. Collaborate with cross-functional teams to influence architecture a...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$110K - $130K *

Transform acquisition program management by leading multidisciplinary teams, ensuring compliance with DoD processes, and driving operational excellence in a dynamic environment. Play a key role in ris...

Bethesda, MDRemote

Today

  •   Less than 5 years exp.  •   Business Services

$115K - $160K *

Lead incident response initiatives, utilizing advanced forensic techniques to protect organizations from sophisticated cyber threats. Collaborate with teams to deliver high-quality investigations and...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$133K - $220K *

Lead innovative security solutions by enhancing database security posture, collaborating with cross-functional teams to design and implement robust security features, and driving business impact throu...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.