Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$120K - $156K *

Create impactful Treasury solutions by leading dynamic teams and engagements. Ensure quality delivery, build client relationships, and drive business growth through strategic advisory and operational...

Chicago, ILRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $190K *

Transform cybersecurity through automation, driving impactful solutions across diverse security functions. Leverage AI to enhance incident response and promote efficient processes within a fast-paced...

Richmond, VARemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$65K - $121K *

Join a team that's dedicated to managing complex contracts for government projects. You'll oversee proposal preparation, contract negotiations, and compliance, ensuring effective collaboration across...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$110K - $130K *

Unlock customer potential by driving engagement and satisfaction throughout their journey. Manage accounts, foster relationships, and ensure value realization to support retention and growth in a dyna...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$75K - $158K *

Accelerate your career by joining a dynamic team focused on transforming logistics and finance through SAP S/4HANA. Collaborate with cross-functional stakeholders to ensure quality and reliability in...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Transform architecture strategy in a leading healthcare organization, driving innovation and collaboration across IT infrastructure while ensuring alignment with business and regulatory standards...

Massachusetts, USRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Staffing

$117K - $161K *

Engage with us to optimize Workday integrations and reporting solutions. As a technical expert, you'll collaborate with HR, Finance, and IT to ensure secure data exchange and actionable insights that...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Food & Beverages

$85K - $100K *

Join us as a Software Consultant to enhance customer operations through expert guidance on our software suite, driving productivity and fostering strong relationships within your territory...

Texas, USRemote

3 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$72K - $122K *

Join a dynamic team to support clinical systems and enhance user workflows. You'll analyze needs, design/testing systems, and train personnel while coordinating with clinical staff and ensuring effect...

New Bedford, MARemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$75K - $95K *

Join a team that's dedicated to delivering engaging, role-based training for federal enterprise applications. Collaborate with multidisciplinary partners to enhance user proficiency and ensure measura...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$130K *

Shape the future of IT security by enhancing compliance and risk management. Collaborate with cross-functional teams to identify risks and implement effective solutions, ensuring the organization meet...

United StatesRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$170K - $200K *

Drive portfolio strategy and execution by transforming market needs into profitable offers. Collaborate across teams to ensure alignment and operational readiness, enhancing sales confidence and optim...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Drive strategic capture initiatives to expand federal market presence, managing the full lifecycle from opportunity qualification to proposal submission. Collaborate with leadership and teams to devel...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $216K *

Drive successful IT program delivery and customer relationships while managing financial performance and team leadership. Engage with stakeholders to identify growth opportunities and ensure high-qual...

RemoteRemote

1 week ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$130K - $160K *

Engineer robust security solutions to protect users and partners. Collaborate with a dynamic team to enhance security across infrastructure, applications, and compliance, while writing production code...

New York City, NYRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$230K - $273K *

Transform the mobile integration landscape by spearheading the deployment of secure, efficient systems that enable seamless operation of USPS and Government Agency applications across Android devices...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$200K *

Drive your career by leading technical architecture and AI tooling development in a dynamic company transitioning to multi-platform solutions. Collaborate with teams, mentor talent, and engage with en...

United StatesRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$119K - $136K *

Unlock your potential by leading workforce transformation solutions that align business priorities with technology ecosystems. Engage with executives to design impactful strategies and drive measurabl...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $100K *

Contribute to the development and integration of mission-critical systems, applying systems engineering principles to ensure high reliability and security. Collaborate across teams to support the enti...

Pittsfield, MARemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Help us optimize system solutions by analyzing user needs, documenting requirements, and bridging the gap between IT and business. You will play a key role in driving system development and implementa...

Washington, DCRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

$150K - $180K *

Transform client relationships by engaging with C-suite executives to drive strategic account growth. Collaborate on tailored solutions and industry insights, ensuring alignment with client goals and...

Mississauga, ONRemote

1 week ago

  •   11 - 15 years exp.  •   Enterprise Technology

$95K - $115K *

Champion innovative solutions as a Business Solutions Analyst, collaborating with healthcare organizations to drive strategic initiatives and operational excellence across diverse projects and deliver...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $160K *

Join a dynamic team to build and enhance security practices, ensuring robust protection of sensitive data. Collaborate across engineering to create secure frameworks, manage identities, and fortify cl...

San Francisco, CARemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$150K - $180K *

Transform customer success by leading strategic post-sales initiatives, fostering C-level partnerships, and driving business transformation. Ensure predictable renewals and maximize value through coll...

Addison, TXRemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Lead the CDI Department by acting as a clinical and technical resource, facilitating communication between customers and leadership, and ensuring operational standards are met through effective workfl...

New Orleans, LARemote

Today

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.