Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$140K - $160K *

Deliver impactful financial management solutions by leading a team of 8-10 professionals in federal financial systems. Engage with stakeholders to analyze data, support decision-making, and ensure suc...

Arlington, VARemote

3 days ago

  •   11 - 15 years exp.  •   Business Services

$100K - $160K *

Empower the future of data center commissioning by leading complex projects, fostering client relationships, and mentoring junior staff while ensuring compliance with energy standards and financial ac...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Technical Services

$112K - $179K *

Take ownership of a diverse portfolio of GSA/GWAC contracts, ensuring compliance and operational excellence through strategic management, collaboration with stakeholders, and training initiatives for...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$112K - $179K *

Lead the charge in managing a diverse portfolio of government contracts, ensuring compliance and performance excellence while advising program teams and building strong relationships for mission succe...

United StatesRemote

Reposted 4 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$112K - $179K *

Join a team that's pivotal in managing complex government contracts. You will advise and collaborate with program teams to ensure contract compliance and success from start to finish, while fostering...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$125K - $150K *

Join a proactive team as you independently investigate sophisticated threat actors. Use your expertise in threat intelligence to enhance security measures, develop solutions, and automate workflows to...

RemoteRemote

Reposted 4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Champion strategic alliances to drive growth, enhance partnerships, and align cross-functional teams. Lead initiatives that translate company goals into actionable plans, ensuring measurable results a...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$115K - $218K *

Join a team that designs innovative cloud solutions for healthcare. Lead migrations of Epic systems to cloud platforms, ensuring security and performance while collaborating with IT and healthcare exp...

Dallas, TXRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$130K - $150K *

Join a team that's revolutionizing revenue operations by owning HubSpot, building scalable systems, and driving growth through integrated data management. This hands-on role is pivotal in shaping our...

Cincinnati, OHRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Champion the future of electronic security by managing diverse projects nationwide. Lead technical teams, ensure compliance, and build strong customer relationships while driving project success and g...

Alaska, USRemote

Yesterday

  •   5 - 7 years exp.  •   Staffing

$140K - $200K *

Join a team that's driving strategic partnerships and market growth. Leverage your expertise in channel sales to collaborate with key partners, develop business plans, and enhance visibility in the cy...

Chicago, ILRemote

6 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Unlock potential by spearheading revenue growth through consultative sales. Cultivate client relationships, identify opportunities, and exceed sales targets while ensuring a seamless client experience...

Phoenix, AZRemote

1 month ago

  •   Less than 5 years exp.  •   Business Services

$139K - $185K *

Lead the charge in advancing our IT PMO by establishing governance frameworks, optimizing project delivery, and integrating innovative technologies. Collaborate with stakeholders to enhance program ma...

Minnesota, USRemote

Today

  •   8 - 10 years exp.  •   Healthcare

$69K - $101K *

Empower our Micro-Fulfillment Operations team by ensuring optimal performance and reliability of automated systems. Engage with customers to troubleshoot and resolve complex technical issues, enhancin...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$75K - $90K *

Optimize onsite environmental operations by leading a dedicated team, ensuring compliance, maximizing efficiency, and driving performance through strategic planning and continuous improvement in hazar...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Energy & Utilities

$150K - $180K *

Drive your career as a Compliance Architect, guiding clients through CMMC compliance journeys. Collaborate with stakeholders to assess risks, develop strategic roadmaps, and ensure alignment with regu...

RemoteRemote

Reposted today

  •   8 - 10 years exp.  •   Information Technology

$140K - $180K *

Empower teams by leading the technical vision and delivery standards for ServiceNow. Drive high-quality implementations across engagements while mentoring talent and collaborating with management to e...

United StatesRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Business Services

$90K - $120K *

Innovate and enhance platform operations as a technical expert, driving implementation and administration of HaloPSA. Collaborate with teams to streamline processes, improve visibility, and ensure sea...

Napa, CARemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$115K - $140K *

Drive GRC initiatives by building and testing security controls, assessing risks, and automating evidence collection. Collaborate with teams to enhance compliance and support audits while ensuring eff...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$206K - $283K *

Drive technical leadership and guide customers through their security transformation journeys, ensuring solution fit and ongoing technical health throughout the customer lifecycle while exceeding sale...

Charlotte, NCRemote

Yesterday

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $120K *

Transform global security by leveraging your technical expertise to detect, respond, and remediate incidents in real-time. Collaborate with a dynamic team to enhance processes and deliver exceptional...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Drive operational excellence by developing and maintaining standards, ensuring consistency across markets, and collaborating with cross-functional teams to enhance processes and documentation for opti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Join a team that's redefining regulatory excellence by leading global strategies for product development and post-marketing. Drive cross-functional collaboration and ensure timely execution of regulat...

North Carolina, USRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$120K - $250K *

Take ownership of sales success by developing strategic approaches, cultivating relationships, and effectively communicating tailored solutions to clients, while collaborating across teams to drive bu...

Arkansas, USRemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$180K - $275K *

Unlock potential by defining and driving the technical vision and product strategy for Next-Gen SIEM and Log Management products, ensuring alignment with market needs and customer motivations while fo...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.