Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$80K - $95K *

Join a team that's dedicated to ensuring the reliability of mission-critical data center operations through comprehensive testing and commissioning of electrical and mechanical systems. Bring your tec...

Ohio, USRemote

Yesterday

  •   Less than 5 years exp.  •   Staffing

$105K - $175K *

Lead the charge in Model-Based Systems Engineering, collaborating with experts across diverse domains to develop cutting-edge solutions. Utilize your skills in SysML and modeling tools to drive innova...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$128K - $187K *

Transform your career by leveraging cutting-edge MBSE expertise across diverse domains. Engage with top technologies, collaborate with skilled engineers, and drive innovation in dynamic environments w...

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4 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$63K - $103K *

Transform business analysis within the Judiciary by gathering requirements, designing workflows, and supporting IT projects. Collaborate with diverse teams to enhance user experience and deliver impac...

Trenton, NJRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $183K *

Innovate the future of healthcare technology by developing scalable applications that streamline specialty prescriptions. Collaborate with a skilled team to enhance user experience and drive efficienc...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$110K - $115K *

Lead the charge in enhancing security through strategic SIEM design, managing incident response, and optimizing cyber threat analytics. This role ensures continuous improvement of security operations...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Transportation

$82K - $172K *

Transform your career by leading the integration of Oracle EBS and Cloud EPM. Spearhead data flow management and architectural redesign while collaborating with technical teams to enhance financial sy...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$70K - $105K *

Unlock potential by providing exceptional support and training in clinical software, ensuring customer satisfaction through effective communication and problem-solving in a fast-paced environment. Joi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Business Services

$100K - $140K *

Champion the proposal process by leading submissions, coordinating resources, and ensuring strategic alignment. Drive improvements in proposal development while fostering collaboration across teams to...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$125K - $225K *

Champion risk management strategies for a large-scale industrial project, collaborating with multidisciplinary teams to identify and mitigate risks, ensuring informed decision-making and project succe...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$95K - $115K *

Transform manufacturing processes by designing and implementing advanced PLC/HMI control systems for food and beverage plants, ensuring optimal performance and efficiency through innovative automation...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$120K - $160K *

Advance your career by leading Cyber Security Operations, ensuring the safety of guest and colleague data. Collaborate with a dynamic team to enhance incident response, threat detection, and operation...

Chicago, ILRemote

3 days ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$149K - $250K *

Transform client security outcomes by leveraging technical expertise and customer engagement. Drive pre-sales efforts, conduct impactful demonstrations, and build strong relationships with stakeholder...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$90K - $110K *

Develop and implement quality management processes, driving continuous improvement and operational excellence. Collaborate with teams to enhance training, project management, and system enhancements...

Georgia, USRemote

1 week ago

  •   5 - 7 years exp.  •   Transportation

$150K - $280K *

Drive system architecture definition and refine requirements in a collaborative, agile environment. Engage with cross-functional teams to ensure alignment with customer needs and technical solutions...

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Yesterday

  •   5 - 7 years exp.  •   Aerospace & Defense

$127K - $172K *

Elevate health outcomes by managing membership operations and compliance. Lead strategic initiatives, streamline processes, and collaborate with stakeholders to enhance the national organ donation and...

Maryland, USRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Empower mission success by engineering and enhancing unified communications platforms, ensuring seamless voice and collaboration for secure operations. Drive troubleshooting, support implementation, a...

RemoteRemote

Reposted 5 days ago

  •   11 - 15 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Grow your career by optimizing clinical applications, enhancing radiology workflows, and collaborating with healthcare teams nationwide to ensure seamless operations and technical support across syste...

RemoteRemote

Reposted today

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$190K - $225K *

Lead the charge in delivering exceptional services to State and Local Government accounts. Drive strategic initiatives, enhance customer satisfaction, and support business development efforts while ma...

Pennsylvania, USRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$186K - $353K *

Champion innovative IP strategies and drive engagement across teams, providing expert legal guidance on patents, trademarks, and copyrights. Collaborate with engineers and management to mitigate risks...

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6 days ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$131K - $223K *

Join us in advancing cloud infrastructure as a Lead DevOps Engineer, managing AWS environments and enhancing automation practices. Collaborate with diverse teams to ensure reliable, secure, and effici...

Reston, VARemote

4 weeks ago

  •   8 - 10 years exp.  •   Business Services

$104K - $116K *

Join a team that's redefining application support by leveraging modern web technologies. You'll ensure the availability of critical enterprise applications, troubleshoot issues, and collaborate with c...

Frisco, TXRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$75K - $158K *

Engage with agile teams as a Scrum Master to drive effective collaboration, remove impediments, and enhance productivity in a scaled agile framework. Foster relationships with stakeholders to ensure s...

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Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $160K *

Join our U.S. Government Support Engineering team to tackle complex technical challenges in secure environments. Leverage your Linux expertise and customer support skills to enhance GitLab's performan...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$83K - $114K *

Empower your career by leading diverse construction projects across the U.S. and overseas. Manage teams, ensure quality, and maintain safety standards while delivering mission-critical facilities on t...

Alexandria, VARemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.