Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
$279K - $342K *
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Senior Middleware Administrator
$110K - $130K *
Lead the charge in optimizing enterprise middleware platforms through effective administration, automation, and security management, ensuring high availability and compliance while enhancing operation...
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$80K - $95K *
Empower our analyst relations program by managing evaluations, timelines, and coordination. Collaborate with stakeholders to ensure accurate, timely engagement and support market insights for strategi...
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Senior Vice President, Client Implementations, Revenue Cycle (REMOTE)
$175K - $210K *
Unlock potential by leading implementation strategies to enhance client onboarding and satisfaction. Drive efficiencies across systems, manage a dedicated team, and collaborate with departments to ens...
4 weeks ago
Senior Sales Executive - State & Local Government
$140K - $180K *
Champion growth by leveraging your consultative sales expertise to secure contracts and enhance client relationships in the public sector, specifically within Medicaid and Human Services programs. Dri...
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Senior Regulatory Affairs Specialist (Remote - United States)
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Champion regulatory strategies to accelerate product approvals and compliance. Lead a dynamic team in supporting innovative medical devices, ensuring alignment with global regulations while fostering...
3 days ago
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$85K - $110K *
Shape the future of healthcare payment integrity by developing and enhancing clinical and coding solutions. Collaborate with cross-functional teams to ensure compliance with coding standards and optim...
1 week ago
Information Systems Operations Manager
$100K - $120K *
Lead the charge in optimizing our Information Systems operations, ensuring seamless support for hardware and software. Manage a dedicated team while enhancing productivity through AI tools and maintai...
Today
Senior Consultant - State Government IT IV&V
$90K - $130K *
Pioneer innovative solutions for state government clients by leading IV&V projects, providing expert guidance on system implementations, and ensuring project success through effective communication an...
1 week ago
Director, Capture Management - EMG
$180K - $200K *
Optimize strategic capture management efforts to drive growth and enhance win rates. Lead complex proposals, collaborate with teams, and leverage market insights to secure new opportunities and re-com...
Yesterday
$80K - $96K *
Lead transformational initiatives in a dynamic training program, cultivating exceptional teams while mastering operations and business management in the home health and hospice sectors...
Reposted 1 month ago
Consultant - Pharmacovigilance/Safety Systems Implementation (Remote)
$80K - $200K *
Veeva Systems is seeking a Consultant for the implementation of their Vault Safety solution in the life sciences sector. This remote role involves collaborating with customers to define business proce...
Reposted 4 weeks ago
Hardware Development Engineer (remote)
$95K - $115K *
Support the design and development of electronic hardware systems for Navy undersea warfare programs. Collaborate on circuit design, testing, and integration efforts while ensuring compliance with tec...
4 weeks ago
Kyriba Implementation Senior Analyst
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Join a dynamic team to drive system implementations and client training in Treasury. Shape seamless operations through relationship management and project leadership while maintaining high delivery st...
Reposted 2 weeks ago
$110K - $130K *
Elevate your career by leading a technical team to enhance collaboration tools in a dynamic, cloud-based environment. Engage with federal clients, drive Agile practices, and ensure toolset efficiency...
3 weeks ago
Senior Analyst of Transformation
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Join a team that's driving transformative change through strategic analysis and execution. This high-visibility role collaborates with leadership to ensure progress on critical initiatives and enhance...
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AI Solutions Developer (Remote)
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Champion innovation by architecting and deploying AI solutions that enhance operational efficiency and sales enablement. Collaborate with cross-functional teams to create impactful applications that d...
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Deliver seamless integration and Tier 3 support for secure mobile infrastructure. Collaborate with enterprise stakeholders to ensure compliance, performance, and customer satisfaction while managing c...
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Senior Compliance Assurance Advisor
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Transform your career by leading compliance assurance initiatives that enhance the reliability of the North American electric grid. Collaborate with industry stakeholders to develop and implement risk...
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Systems Administrator - 2nd Shift
$97K - $126K *
Drive system excellence by overseeing installation, configuration, and maintenance of operating systems and servers, ensuring optimal performance and security while supporting business needs and compl...
1 week ago
SAP Principle Source to Pay Systems Expert
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Join our team to design and implement Source to Pay applications, influencing project outcomes and enhancing system effectiveness while collaborating with cross-functional teams in a dynamic remote en...
2 weeks ago
Solutions Architect II (Higher Ed/SAAS/SIS/ERP)
$110K - $130K *
Lead the charge in designing innovative solutions across multiple higher education platforms. Collaborate with teams to implement best practices and ensure alignment with institutional goals, driving...
3 weeks ago
Forward Deployed Full Stack Engineer (Active Secret Clearance)
$120K - $145K *
Drive impactful software solutions by embedding with clients, transforming ambiguous needs into deployable features across secure environments. Collaborate closely with users and stakeholders to deliv...
Today
Senior Analyst, Business Resilience & Crisis Management & Travel Security (Remote)
$68K - $131K *
Champion global traveler safety by leading risk assessments, monitoring events, and coordinating responses. Engage in crisis management and develop training materials to ensure preparedness and compli...
Yesterday
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.