Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$148K - $248K *

Drive growth by leading a field-based sales team focused on federal agencies. You'll strategize, coach, and negotiate to enhance adoption of our DevSecOps platform, ensuring alignment with agency need...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $165K *

Empower your career by driving revenue growth in the Federal Civilian sector. Engage with C-level executives to architect and close complex cybersecurity solutions, expanding our footprint across U.S...

Reston, VARemote

Yesterday

  •   5 - 7 years exp.  •   Consumer Technology

$77K - $110K *

Develop your career by contributing to Power BI dashboard creation and maintenance, ensuring accurate data visualization and reporting for key metrics. Collaborate with stakeholders to enhance workfor...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$73K - $102K *

Drive innovative SAP solutions by developing and implementing Fiori applications, enhancing ABAP capabilities, and collaborating with teams to meet client needs in a dynamic environment...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$108K - $149K *

Shape the future of technical marketing by crafting compelling narratives that engage practitioners and influencers, driving curiosity and interest in cutting-edge cybersecurity solutions across our i...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

$80K - $96K *

Join a team that's dedicated to transforming client needs into effective solutions. As a Business Analyst I, you'll bridge teams, support integrations, and enhance processes within the Financial Servi...

West Des Moines, IARemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$129K - $239K *

Take ownership of export compliance operations, leading high-impact processes across US and international sites. Ensure efficient goods movement while navigating diverse regulatory frameworks and mana...

RemoteRemote

2 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Deliver impactful workforce insights by developing and optimizing Workday reports and dashboards. Collaborate with HR and stakeholders to ensure data accuracy, security, and compliance while enhancing...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$130K - $150K *

Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$132K - $251K *

Lead the charge in driving modernization for National and DoD communications, influencing policies and cultivating industry partnerships to enhance strategic deterrence capabilities and resilient comm...

Nebraska, USRemote

2 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$80K - $120K *

Transform the workplace experience by enabling colleagues to leverage technology and AI tools. Collaborate across teams to develop training programs, create valuable resources, and enhance productivit...

New York City, NYRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$72K - $135K *

Champion the design and delivery of impactful learning initiatives, ensuring alignment with business needs while enhancing the learner experience across a global Operations organization...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$120K - $145K *

Innovate incident response by leveraging AI and human expertise to enhance threat detection, investigation, and containment across a dynamic cloud environment. Collaborate with cross-functional teams...

San Francisco, CARemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$125K - $150K *

Unlock your potential as you drive market success for innovative Application Security solutions, collaborating with teams to enhance customer value and digital transformation strategies across diverse...

Austin, TXRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $204K *

Lead the design and implementation of innovative IT solutions, driving transformation for enterprise clients while ensuring alignment with business goals. Collaborate across teams to craft technical s...

United StatesRemote

Reposted 2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$88K - $109K *

Drive strategic success and growth by managing high-value partnerships, ensuring customer satisfaction, and leading post-sale initiatives for enterprise accounts. Shape the future of customer engageme...

Boston, MARemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$99K *

Empower healthcare access by providing technical support for Epic Cheers Call Management. Enhance user experience through issue resolution, workflow optimization, and the introduction of digital engag...

Morrisville, NCRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Lead customer success programs from onboarding to adoption, ensuring smooth collaboration among engineering, product, and client teams. Drive accountability, maintain clarity, and deliver measurable v...

Pleasanton, CARemote

Reposted 3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$107K - $204K *

Contribute to designing and implementing SAP BTP solutions, collaborating with teams to meet integration requirements and develop custom iFlows for effective data management in a dynamic environment...

Texas, USRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$100K - $175K *

Grow expertise in Operational Technology security, leading critical engagements across industrial systems. Collaborate on advanced methodologies while mentoring others and contributing to pivotal rese...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$200K - $205K *

Drive the expansion of our Data Services & Analytics practice by leading technical delivery, managing client relationships, and overseeing project execution. Empower teams to deliver innovative data i...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Enterprise Technology

$110K - $130K *

Engage as a Sanctions Screening SME, driving system design, analysis, and validation. Collaborate with cross-functional teams to enhance screening processes and ensure compliance, while leveraging dee...

Jersey City, NJRemote

Today

  •   8 - 10 years exp.  •   Staffing

$88K - $105K *

Analyze trends and develop strategic reports to enhance revenue cycle efficiency. Collaborate with management and key departments to identify opportunities and risks, presenting data-driven insights t...

Los Angeles, CARemote

3 days ago

  •   Less than 5 years exp.  •   Healthcare

$148K - $190K *

Unlock your potential as you build and maintain integrations that connect security tools to enhance customer workflows. Collaborate with a dynamic team to design, deliver, and support reliable solutio...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $115K *

Unlock potential by shaping innovative solutions for Opioid Treatment Programs and Medication Assisted Treatment. Collaborate with clients and teams to translate complex needs into actionable product...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.