Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$110K - $130K *

Help us enhance our Identity & Access Management systems by engineering and implementing advanced IGA solutions. Collaborate with stakeholders to ensure secure, compliant, and efficient identity gover...

Chicago, ILRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $145K *

Elevate your career by leading a dynamic team of technical consultants, driving operational excellence and strategic delivery for U.S. Federal clients. Collaborate across departments to ensure success...

Reston, VARemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

$185K - $252K *

Unlock potential by leading a team of Pharmacovigilance Scientists to ensure compliant, high-quality safety surveillance for clinical products. Collaborate with cross-functional teams to identify and...

New Jersey, USRemote

Reposted 6 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$129K - $193K *

Empower your career by leading complex IT initiatives, ensuring disciplined execution and governance across cross-functional projects. Drive operational readiness and enhance delivery rigor while coll...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$69K - $105K *

Join a team that's dedicated to enhancing application and cloud security through automated testing and manual assessments. Collaborate with development and DevOps teams to integrate security practices...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$214K - $292K *

Champion AI-driven portfolio strategies and lead comprehensive reporting initiatives to enhance decision-making and optimize performance across cross-functional teams in a hybrid role focused on innov...

New Jersey, USRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Accelerate your career by partnering with leaders to develop innovative solutions, guide engineering best practices, and ensure high-quality infrastructure. Collaborate with teams to achieve technical...

Mclean, VARemote

Reposted 6 days ago

  •   Less than 5 years exp.  •   Enterprise Technology

$166K - $200K *

Lead the charge in shaping transformative solutions for national security missions. As a senior technical leader, you'll drive innovation, coordinate emerging technologies, and influence strategic dec...

Colorado, USRemote

Today

  •   11 - 15 years exp.  •   Information Technology

$93K - $143K *

Transform your career by leading innovative Identity & Authentication solutions. Drive complex network technology initiatives, enhance system resilience, and collaborate with cross-functional teams to...

CanadaRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$172K - $287K *

Contribute to strategic account management and client relationships, ensuring delivery of cybersecurity services that align with client needs while driving growth, retention, and value across multiple...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $150K *

Lead the charge in transforming laboratory informatics by leveraging 15+ years of expertise in LIMS, CDS, and clinical research systems to drive compliance, modernization, and successful program deliv...

San Diego, CARemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Join a team that's driving project excellence by leading a diverse group of Project Managers. You'll optimize resources, enhance delivery outcomes, and foster high performance across critical VA initi...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Transform geospatial data into impactful maps and applications, supporting intelligence operations. Collaborate with teams to analyze and visualize data, ensuring compliance with standards while enhan...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Technical Services

$106K - $198K *

Lead the charge in developing mission-critical Command & Control solutions. Collaborate with cross-functional teams to define system requirements and create innovative architectures that meet diverse...

Colorado, USRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

$120K - $193K *

Transform enterprise security by leading product strategy and delivery, focusing on data protection and compliance. Drive innovation through AI integration, ensuring scalable solutions that meet evolv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$91K - $163K *

Join a team that's transforming healthcare technology by developing and implementing EMR interfaces. Leverage your expertise in integration and engineering to enhance system functionality and support...

Eden Prairie, MNRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Transform your career by leading incident response and threat investigations in a dynamic Security Operations Center. Collaborate with teams to enhance security practices and protect enterprise enviro...

Boston, MARemote

Yesterday

  •   Less than 5 years exp.  •   Staffing

$176K - $243K *

Lead the charge in transforming oncology care by developing strategic partnerships and innovative programs that enhance patient-centered services and operational efficiency across healthcare systems...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$144K - $189K *

Transform your career by leading product development for FedRAMP Moderate applications. Collaborate with cross-functional teams to drive compliance, optimize the roadmap, and enhance customer value in...

Seattle, WARemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Join a team that's dedicated to enhancing dental health IT solutions. This role combines project management with technical expertise in Dentrix and Cerner Millennium to optimize EHR systems for improv...

Maryland, USRemote

Today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Unlock potential by leading compliance and security processes in the software development lifecycle. Ensure adherence to industry standards, manage audits, and drive training initiatives to maintain h...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$27K - $244K *

Lead the charge in transforming identity and access management with innovative strategies ensuring identity is the core of security. Drive and oversee IAM programs, ensuring compliance and operational...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$140K - $170K *

Join a team that's shaping the future of cybersecurity by designing and maintaining robust Splunk data pipelines. Collaborate with cross-functional teams to enhance operational processes and ensure da...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$105K - $231K *

Transform HR solutions by leading Oracle HCM Cloud implementations for federal agencies. Shape functional designs and lead workshops to ensure effective migration from legacy systems in an Agile envir...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$148K - $263K *

Manage and maintain Oracle databases, leveraging expertise in Unix scripting and PL/SQL. Engage in data migration, interface development, and automated task management while collaborating within a dyn...

United StatesRemote

Today

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.