Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
$79K - $156K *
Lead the charge in analyzing and developing enterprise data solutions, collaborating with stakeholders to translate requirements into actionable insights. Drive innovation in data management and integ...
3 days ago
Infrastructure Security Engineer (Senior/Principal)
$170K - $325K *
Elevate your career by securing and managing the transition to a hybrid-cloud infrastructure. Own identity management, cloud security, and developer tooling while leading incident response and threat...
Yesterday
$160K - $200K *
Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...
Today
Staff Product Security Architect
$168K - $238K *
Drive proactive security architecture strategies to enhance software resilience, collaborating with engineering teams to embed security into development workflows while minimizing manual intervention...
4 weeks ago
Senior Security AI Risk Analyst
$167K - $251K *
Lead the charge in ensuring security within AI systems by assessing risks, conducting reviews, and working cross-functionally to deliver practical solutions and foster collaborative partnerships for e...
4 weeks ago
ATC Deployment Enablement Manager
$132K - $208K *
Lead the charge in transforming data center network designs into seamless execution. Drive end-to-end delivery of infrastructure projects, ensuring timely and efficient deployment across multiple site...
Yesterday
Lead Security Operations Analyst
$110K - $130K *
Engage in a dynamic role leading security operations and AI integration. Oversee real-time threat monitoring and incident response while developing automated workflows in a cutting-edge, multi-tenant...
Yesterday
IT Procurement / Purchasing Analyst
$72K - $111K *
Join a dynamic team to lead IT procurement efforts, overseeing the full purchasing cycle. Ensure compliance with Government requirements while facilitating timely acquisition of materials for critical...
3 weeks ago
$102K - $138K *
Elevate product strategy and delivery in a scaled Agile framework, ensuring business value through effective collaboration, backlog management, and strategic execution across Agile Release Trains for...
3 weeks ago
Client Executive III (RapidScale) (Remote)
$108K - $130K *
Champion new business growth by driving enterprise sales, managing complex deals, and leveraging cloud solutions. Engage C-suite stakeholders to deliver tailored outcomes and expand market presence in...
3 days ago
$140K - $190K *
Lead the charge in incident coordination and response, managing investigations across security breaches, data loss, and privacy incidents. Collaborate with stakeholders to ensure timely resolutions an...
Today
Clinical Research Associate II
$80K - $95K *
Optimize clinical research processes by conducting comprehensive monitoring visits, ensuring adherence to quality standards, and facilitating effective communication among project teams and sites acro...
Today
$79K - $105K *
Shape the future of patient care by coordinating high-quality, cost-effective services. Utilize your clinical expertise to advocate for members, ensuring appropriate care transitions and fostering col...
2 days ago
$83K - $124K *
Unlock potential by leading the design and implementation of CI/CD pipelines, enhancing software delivery and operational stability for enterprise applications while collaborating with cross-functiona...
2 days ago
Software Engineering Technical Leader (remote) - 2025538
$151K - $222K *
Elevate your career by leading software security governance initiatives. Drive transformation of security requirements into actionable workflows while collaborating with cross-functional teams to enha...
1 week ago
$100K - $120K *
Take ownership of IT operations by building support infrastructure, managing vendor relations, and ensuring seamless tech experiences across teams. Collaborate closely with security teams to maintain...
3 weeks ago
Associate Strategic Insights Manager (REMOTE)
$89K - $148K *
Empower strategic decision-making by generating actionable insights from market trends and customer data. Collaborate with teams to analyze healthcare dynamics and support growth initiatives across Cu...
1 week ago
$95K - $115K *
Champion project success by leading cross-functional teams to deliver innovative business solutions on time and within budget, while managing risks and fostering collaboration across departments to en...
1 week ago
Director, Organizational Change Management - RT Specialty
$120K - $150K *
Lead organizational change initiatives, driving employee adoption and engagement through strategic communication and training. Collaborate with leaders to assess readiness, mitigate resistance, and en...
1 week ago
$145K - $185K *
Transform your career with a pivotal role in cybersecurity, managing critical security technologies and responding to incidents in a fast-paced, remote environment. Collaborate with teams to protect a...
4 weeks ago
Client Executive III (RapidScale) (Remote)
$89K - $229K *
Champion new business growth by driving enterprise sales and building strong C-suite relationships. Leverage cloud expertise to manage complex deals and exceed quotas in a competitive environment, ens...
2 days ago
Client Executive III (RapidScale) (Remote)
$110K - $130K *
Drive new business acquisition in strategic markets by leveraging cloud expertise and executive relationships. This high-impact role demands a disciplined seller with a proven track record in complex...
3 days ago
Client Executive III (RapidScale) (Remote)
$108K - $130K *
Unlock potential by driving new business acquisition in competitive markets. Leverage your expertise in cloud solutions and enterprise sales to build relationships with C-level executives, manage comp...
3 days ago
Client Executive III (RapidScale) (Remote)
$110K - $130K *
Transform your career by driving new business acquisition in strategic markets. Leverage your enterprise sales expertise to build relationships with C-level executives and manage complex sales cycles...
3 days ago
Client Executive III (RapidScale) (Remote)
$110K - $130K *
Unlock potential by driving new business acquisition in strategic markets. As a key player, you'll manage complex sales cycles, engage C-level executives, and leverage cloud solutions to deliver excep...
3 days ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.