Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$110K - $130K *

Engage in a dynamic role leading security operations and AI integration. Oversee real-time threat monitoring and incident response while developing automated workflows in a cutting-edge, multi-tenant...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Enterprise Technology

$72K - $111K *

Join a dynamic team to lead IT procurement efforts, overseeing the full purchasing cycle. Ensure compliance with Government requirements while facilitating timely acquisition of materials for critical...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Enterprise Technology

$102K - $138K *

Elevate product strategy and delivery in a scaled Agile framework, ensuring business value through effective collaboration, backlog management, and strategic execution across Agile Release Trains for...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$108K - $130K *

Champion new business growth by driving enterprise sales, managing complex deals, and leveraging cloud solutions. Engage C-suite stakeholders to deliver tailored outcomes and expand market presence in...

San Antonio, TXRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$140K - $190K *

Lead the charge in incident coordination and response, managing investigations across security breaches, data loss, and privacy incidents. Collaborate with stakeholders to ensure timely resolutions an...

Chicago, ILRemote

Today

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Optimize clinical research processes by conducting comprehensive monitoring visits, ensuring adherence to quality standards, and facilitating effective communication among project teams and sites acro...

Toronto, ONRemote

Today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$79K - $105K *

Shape the future of patient care by coordinating high-quality, cost-effective services. Utilize your clinical expertise to advocate for members, ensuring appropriate care transitions and fostering col...

Hopewell, NJRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$83K - $124K *

Unlock potential by leading the design and implementation of CI/CD pipelines, enhancing software delivery and operational stability for enterprise applications while collaborating with cross-functiona...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$151K - $222K *

Elevate your career by leading software security governance initiatives. Drive transformation of security requirements into actionable workflows while collaborating with cross-functional teams to enha...

North Carolina, USRemote

1 week ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$100K - $120K *

Take ownership of IT operations by building support infrastructure, managing vendor relations, and ensuring seamless tech experiences across teams. Collaborate closely with security teams to maintain...

Brooklyn, NYRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$89K - $148K *

Empower strategic decision-making by generating actionable insights from market trends and customer data. Collaborate with teams to analyze healthcare dynamics and support growth initiatives across Cu...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Champion project success by leading cross-functional teams to deliver innovative business solutions on time and within budget, while managing risks and fostering collaboration across departments to en...

Portland, ORRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$120K - $150K *

Lead organizational change initiatives, driving employee adoption and engagement through strategic communication and training. Collaborate with leaders to assess readiness, mitigate resistance, and en...

Ohio, USRemote

1 week ago

  •   11 - 15 years exp.  •   Finance & Insurance

$145K - $185K *

Transform your career with a pivotal role in cybersecurity, managing critical security technologies and responding to incidents in a fast-paced, remote environment. Collaborate with teams to protect a...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Legal & Accounting

$89K - $229K *

Champion new business growth by driving enterprise sales and building strong C-suite relationships. Leverage cloud expertise to manage complex deals and exceed quotas in a competitive environment, ens...

San Diego, CARemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Drive new business acquisition in strategic markets by leveraging cloud expertise and executive relationships. This high-impact role demands a disciplined seller with a proven track record in complex...

Austin, TXRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$108K - $130K *

Unlock potential by driving new business acquisition in competitive markets. Leverage your expertise in cloud solutions and enterprise sales to build relationships with C-level executives, manage comp...

Orlando, FLRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Transform your career by driving new business acquisition in strategic markets. Leverage your enterprise sales expertise to build relationships with C-level executives and manage complex sales cycles...

Phoenix, AZRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$110K - $130K *

Unlock potential by driving new business acquisition in strategic markets. As a key player, you'll manage complex sales cycles, engage C-level executives, and leverage cloud solutions to deliver excep...

Raleigh, NCRemote

3 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$98K - $206K *

Bring your expertise to architect solutions in Oracle Fusion Financials, enhancing federal financial operations for military logistics. Lead design efforts to ensure compliance and data integrity acro...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$90K - $125K *

Empower the Activations team by analyzing data, building reports, and supporting documentation in ServiceNow. Collaborate with leadership to present insights and ensure service continuity while enhanc...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Transform insights into impactful strategies by leading market research projects, collaborating with account teams, and delivering compelling narratives that drive client decisions and foster long-ter...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Business Services

$110K - $130K *

Lead the charge in managing informatics projects from planning to delivery, ensuring timely decision-making and risk management. Collaborate with cross-functional teams to enhance health information e...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Business Services

$87K - $157K *

Unlock your potential as a mid-level Software Engineer, driving innovation in AI-enabled platforms. Collaborate with a diverse team to build intelligent agents and backend services, enhancing automati...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Technical Services

$110K - $130K *

Lead contract administration efforts for federal programs, ensuring compliance and effective communication among stakeholders. Utilize expertise in federal acquisition to manage deliverables, document...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.