Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$165K - $185K *

Shape the future of cloud management by leading a dynamic team in delivering VMware by Broadcom solutions. Drive technical excellence, mentor talent, and ensure high-quality service delivery for enter...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$132K - $251K *

Drive enterprise-wide DMSMS management by establishing standardized processes and frameworks to mitigate supplier risks and enhance operational stability, ensuring compliance with government standards...

Arizona, USRemote

3 days ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$95K - $115K *

Join a team that's redefining data management solutions. Leverage your expertise in cloud platforms and analytics to support sales teams, drive customer success, and implement innovative data solution...

Raleigh, NCRemote

4 days ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$148K - $164K *

Optimize cloud security operations by monitoring and securing Azure and AWS environments. Collaborate with teams to integrate security into deployment pipelines and ensure compliance with industry sta...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Finance & Insurance

$143K - $205K *

Engage with customers to drive adoption and value realization of solutions, managing relationships and risks while supporting highly regulated environments. Collaborate with technical stakeholders to...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$135K - $160K *

Champion the development and management of Oracle eBusiness Suite solutions, leading critical projects and resolving advanced technical issues while ensuring compliance with government policies and en...

Virginia, USRemote

1 week ago

  •   15+ years exp.  •   Technical Services

$115K - $130K *

Deliver high-quality training for I&C technicians, ensuring comprehension and performance tracking. Collaborate with teams to enhance training materials and support continuous improvement in a virtual...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $237K *

Lead the charge in designing and deploying innovative cloud solutions, enhancing user experiences while modernizing the DoD environment through strategic cloud migrations and security best practices...

RemoteRemote

2 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$160K - $201K *

Lead the charge in shaping and evolving a global web ecosystem, overseeing strategy, operations, and governance to deliver high-performing digital experiences that drive engagement and business growth...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$125K - $140K *

Lead transformative healthcare initiatives by fostering client relationships, driving impactful research, and developing high-performance teams to achieve strategic goals and business growth...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Business Services

$170K - $180K *

Optimize enterprise network security with hands-on design, implementation, and mentoring. Lead complex projects, drive client success, and contribute to evolving tech standards while cultivating relat...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$64K - $128K *

Empower your career by delivering data analysis on EDI transactions, facilitating tool implementations, and fostering cross-department collaboration to enhance system performance and meet organization...

Baltimore, MDRemote

1 month ago

  •   Less than 5 years exp.  •   Healthcare

$131K - $237K *

Drive enterprise cloud infrastructure design and optimization, ensuring high availability, security, and scalability. Collaborate with diverse teams in a dynamic environment to enhance cloud adoption...

United StatesRemote

Reposted 3 weeks ago

  •   11 - 15 years exp.  •   Technical Services

$111K - $170K *

Lead the establishment and management of an enterprise governance framework for Free and Open Source Software (FOSS) and Software Bills of Materials (SBOMs), ensuring compliance and risk management ac...

Trenton, NJRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$150K - $200K *

Engage in leading a dynamic team dedicated to delivering top-notch offensive security engagements, ensuring delivery quality and client satisfaction, while collaborating with sales to expand accounts...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $105K *

Shape the future of Information Security by assisting in the design, development, and implementation of ISRM Infrastructure systems. Collaborate with teams to ensure compliance, analyze systems perfor...

RemoteRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$172K - $202K *

Join a dynamic team as a Senior Director Analyst, leveraging your expertise to guide senior IT executives in navigating digital workplace strategies. Deliver actionable insights that align technology...

Irving, TXRemote

Yesterday

  •   11 - 15 years exp.  •   Business Services

$114K - $252K *

Transform the enterprise AI landscape by architecting innovative cloud solutions, enabling optimized workflows across government services, and driving team excellence in AI development and integration...

United StatesRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Information Technology

$120K - $175K *

Join a dynamic team as a Security Champion, driving operational security across networks and cloud infrastructures. Collaborate with cross-functional teams to implement effective security controls and...

Irvine, CARemote

2 days ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$79K - $156K *

Lead the charge in analyzing and developing enterprise data solutions, collaborating with stakeholders to translate requirements into actionable insights. Drive innovation in data management and integ...

United StatesRemote

2 days ago

  •   8 - 10 years exp.  •   Enterprise Technology

$170K - $325K *

Elevate your career by securing and managing the transition to a hybrid-cloud infrastructure. Own identity management, cloud security, and developer tooling while leading incident response and threat...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$160K - $200K *

Transform security architecture by defining standards, leading reviews, and managing risks. Collaborate with teams to ensure secure, efficient integration of applications and AI, while maintaining cle...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Information Technology

$168K - $238K *

Drive proactive security architecture strategies to enhance software resilience, collaborating with engineering teams to embed security into development workflows while minimizing manual intervention...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$167K - $251K *

Lead the charge in ensuring security within AI systems by assessing risks, conducting reviews, and working cross-functionally to deliver practical solutions and foster collaborative partnerships for e...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Consumer Technology

$132K - $208K *

Lead the charge in transforming data center network designs into seamless execution. Drive end-to-end delivery of infrastructure projects, ensuring timely and efficient deployment across multiple site...

Colorado, USRemote

Yesterday

  •   8 - 10 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.