Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
SailPoint Engineering lead, IAM
$140K - $180K *
Transform identity governance at scale by leading the SailPoint ISC platform. Drive strategy, architecture, and compliance across global operations while collaborating with cross-functional teams to e...
1 week ago
Test & Validation Integration Engineer - Federal Customer
$110K - $130K *
Lead the charge in ensuring seamless deployment of enterprise-grade infrastructure by integrating, testing, and validating complex systems in a controlled lab environment, enabling rapid field activat...
5 days ago
$110K - $130K *
Optimize client success by leading strategic relationships and enhancing revenue cycle performance. Drive measurable improvements, manage escalations, and ensure value realization across healthcare so...
2 weeks ago
ER Compliance Specialist II (Remote)
$73K - $110K *
Empower organizational success by managing complex employee relations and compliance initiatives. Analyze data, conduct investigations, and collaborate with cross-functional teams to enhance workplace...
2 weeks ago
Proposal Analyst - E2- FT Telework
$59K - $111K *
Lead the proposal management process by developing bid strategies, ensuring compliance with regulations, and coordinating data collection to deliver comprehensive proposals that meet technical and cos...
Yesterday
$100K - $120K *
Optimize business development efforts by leading proposal lifecycle management and team coordination. Drive high-quality submissions while supporting strategic initiatives in IT Government contracting...
3 weeks ago
Storage and Backup Enterprise Services Architect @Advizex (Remote)
$145K - $170K *
Support our dynamic IT team by architecting and leading enterprise storage solutions. Drive innovations in hybrid cloud infrastructures while mentoring fellow professionals and ensuring optimal servic...
3 weeks ago
$133K - $180K *
Drive successful cloud migration projects by leading teams, managing schedules, and optimizing resources. You'll ensure effective stakeholder communication and deliver high-quality services while fost...
Reposted 1 week ago
Senior Tecsys Elite WMS / Distribution ERP Specialist - Remote
$92K - $179K *
Join our team to provide advanced application support for WMS and ERP systems, ensuring operational stability. Collaborate with cross-functional teams to troubleshoot, manage escalations, and improve...
Reposted 3 days ago
$70K - $110K *
Drive your career with a dynamic organization as you manage project finance, ensuring accurate financial reporting and compliance. Collaborate across teams to enhance contract effectiveness and suppor...
3 weeks ago
Sr. Client Services Executive I-Navitus
$85K - $104K *
Lead strategic client relationships by managing complex needs, delivering tailored solutions, and driving long-term growth. Collaborate across teams to ensure high-quality outcomes and client satisfac...
1 week ago
Senior Lead Cloud Architect / Delivery Lead
$112K - $179K *
Pioneer innovative cloud architecture solutions, leading modernization initiatives by integrating legacy systems into scalable environments while ensuring compliance and performance excellence across...
3 weeks ago
Client Operations Specialist - Intelligent Operations
$75K - $100K *
Join a team that's dedicated to enhancing client satisfaction and profitability. As a key player, you'll manage client relationships, support sales processes, and ensure seamless communication between...
3 weeks ago
$80K - $95K *
Transform patient care by ensuring real-time monitoring during complex surgeries. Collaborate with surgical teams to safeguard nervous system integrity, making a critical impact on patient outcomes th...
5 days ago
Mid-Level Security Automation Engineer
$95K - $115K *
Drive security excellence by managing AWS GovCloud environments and enhancing DevSecOps pipelines. Ensure compliance with NIST standards while integrating security controls for continuous protection a...
1 week ago
Mission Systems S/4HANA Wave Deployment Lead, Sr. Manager (REMOTE)
$132K - $251K *
Advance S/4HANA deployment as the key liaison, driving site preparation, cross-functional coordination, and seamless go-live execution while minimizing operational disruptions across assigned Mission...
Reposted 4 days ago
$142K - $180K *
Lead the delivery of innovative healthcare solutions, managing teams and projects from design to deployment. Ensure adherence to stakeholder goals while fostering collaboration and optimizing performa...
4 days ago
$145K - $220K *
Empower us to drive new business sales in OT/Cyber-Physical Systems for state and local government accounts. You'll develop strategies, build relationships, and execute sales plans to enhance cybersec...
2 weeks ago
$145K - $220K *
Engage with state and local government leaders to drive sales of OT/Cyber-Physical Systems solutions. Build strategic relationships, advise on security needs, and collaborate with a diverse team to en...
2 weeks ago
$145K - $220K *
Elevate your career by driving new business sales for OT/Cyber-Physical Systems in state and local government accounts. Leverage your expertise to build relationships, develop strategies, and execute...
2 weeks ago
$145K - $220K *
Join a team that's driving new business sales for cutting-edge OT/Cyber-Physical Systems solutions. Collaborate with government leaders to enhance cybersecurity strategies and foster relationships tha...
2 weeks ago
$145K - $220K *
Unlock new business opportunities by driving sales for OT/Cyber-Physical Systems in state and local government accounts. Collaborate with cross-functional teams to develop strategies, build relationsh...
2 weeks ago
HL7 Interoperability Architect (Remote Opportunity)
$120K - $140K *
Champion healthcare interoperability solutions by designing and implementing enterprise-level architectures. Collaborate with technical teams and stakeholders to ensure compliance with federal standar...
Yesterday
$103K - $181K *
Join a dynamic team to automate and enhance software delivery for critical systems. Collaborate with cross-functional teams to ensure system reliability and performance while supporting national secur...
3 weeks ago
Senior Forward Deployed Engineer (FDE)
$170K - $205K *
Join a dynamic team to lead AI agent deployments in healthcare. Leverage your software engineering expertise and client-facing skills to drive technical delivery, influence product development, and en...
4 days ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.