Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

Remote
caret down
Compensation
caret down
Position Level
caret down
Time Posted
caret down
Industries
caret down
More
1
caret down

$95K - $115K *

Elevate healthcare technology by analyzing and enhancing clinical applications, ensuring optimal solutions meet operational needs. Collaborate with teams to drive impactful improvements, train analyst...

Louisville, KYRemote

3 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$70K - $117K *

Join our team as a Technical Business Analyst, bridging business needs and technical solutions. Drive data-driven projects, optimize processes, and enhance reporting for diverse clients while collabor...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Information Technology

$119K - $161K *

Optimize security solutions by joining our dynamic team, where you'll enhance logging infrastructure, automate processes, and ensure data integrity. Collaborate with cross-functional teams to build ne...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Legal & Accounting

$110K - $130K *

Drive innovation by leading the design and implementation of complex systems, ensuring reliability and scalability while aligning engineering solutions with business objectives in federal IT moderniza...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$100K - $120K *

Shape the future of clinical informatics by leading national pharmacogenomics initiatives. Collaborate across VA systems to enhance precision medicine, optimize data management, and drive impactful he...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$120K - $145K *

Transform enterprise service delivery by leading cross-center operations, enhancing efficiency, and ensuring high-quality IT services across multiple locations. Drive initiatives that improve performa...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$155K - $222K *

Partner with us to drive revenue growth in the AI security market by developing strategic alliances and go-to-market initiatives with key partners, enhancing sales capabilities, and influencing agency...

Washington DC, USRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$195K - $325K *

Drive a culture of cyber risk accountability by leading Technology Risk & Compliance initiatives across Global Supply Chain and Operational Technology, ensuring alignment with business needs and regul...

Philadelphia, PARemote

Today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$171K - $300K *

Champion the evolution of a high-volume data platform, collaborating with engineering and product teams to enhance reliability and efficiency while mentoring senior engineers and driving innovative AI...

San Diego, CARemote

Yesterday

  •   11 - 15 years exp.  •   Information Technology

$140K - $180K *

Transform identity governance at scale by leading the SailPoint ISC platform. Drive strategy, architecture, and compliance across global operations while collaborating with cross-functional teams to e...

Brooklyn, NYRemote

1 week ago

  •   8 - 10 years exp.  •   Real Estate & Construction

$110K - $130K *

Lead the charge in ensuring seamless deployment of enterprise-grade infrastructure by integrating, testing, and validating complex systems in a controlled lab environment, enabling rapid field activat...

La Plata, MDRemote

5 days ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$110K - $130K *

Optimize client success by leading strategic relationships and enhancing revenue cycle performance. Drive measurable improvements, manage escalations, and ensure value realization across healthcare so...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$73K - $110K *

Empower organizational success by managing complex employee relations and compliance initiatives. Analyze data, conduct investigations, and collaborate with cross-functional teams to enhance workplace...

Calabasas, CARemote

2 weeks ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$59K - $111K *

Lead the proposal management process by developing bid strategies, ensuring compliance with regulations, and coordinating data collection to deliver comprehensive proposals that meet technical and cos...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$100K - $120K *

Optimize business development efforts by leading proposal lifecycle management and team coordination. Drive high-quality submissions while supporting strategic initiatives in IT Government contracting...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $170K *

Support our dynamic IT team by architecting and leading enterprise storage solutions. Drive innovations in hybrid cloud infrastructures while mentoring fellow professionals and ensuring optimal servic...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$133K - $180K *

Drive successful cloud migration projects by leading teams, managing schedules, and optimizing resources. You'll ensure effective stakeholder communication and deliver high-quality services while fost...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$92K - $179K *

Join our team to provide advanced application support for WMS and ERP systems, ensuring operational stability. Collaborate with cross-functional teams to troubleshoot, manage escalations, and improve...

Dallas, TXRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Technical Services

$70K - $110K *

Drive your career with a dynamic organization as you manage project finance, ensuring accurate financial reporting and compliance. Collaborate across teams to enhance contract effectiveness and suppor...

Mclean, VARemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $104K *

Lead strategic client relationships by managing complex needs, delivering tailored solutions, and driving long-term growth. Collaborate across teams to ensure high-quality outcomes and client satisfac...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$112K - $179K *

Pioneer innovative cloud architecture solutions, leading modernization initiatives by integrating legacy systems into scalable environments while ensuring compliance and performance excellence across...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$75K - $100K *

Join a team that's dedicated to enhancing client satisfaction and profitability. As a key player, you'll manage client relationships, support sales processes, and ensure seamless communication between...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$80K - $95K *

Transform patient care by ensuring real-time monitoring during complex surgeries. Collaborate with surgical teams to safeguard nervous system integrity, making a critical impact on patient outcomes th...

New Jersey, USRemote

5 days ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Drive security excellence by managing AWS GovCloud environments and enhancing DevSecOps pipelines. Ensure compliance with NIST standards while integrating security controls for continuous protection a...

Scott Air Force Base, ILRemote

1 week ago

  •   5 - 7 years exp.  •   Enterprise Technology

$132K - $251K *

Advance S/4HANA deployment as the key liaison, driving site preparation, cross-functional coordination, and seamless go-live execution while minimizing operational disruptions across assigned Mission...

North Carolina, USRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.