Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$116K - $187K *

Lead the charge in integrating healthcare systems, ensuring secure data exchange across platforms. Drive interoperability initiatives, optimize APIs, and enhance clinical data capabilities while suppo...

Providence, RIRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $115K *

Transform system integrations and testing practices in an Agile team, enhancing user experiences and supporting cutting-edge LMR technology solutions for community safety, while advancing your technic...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$139K - $213K *

Drive relationships and sales success by positioning technology solutions within the U.S. Army. Leverage existing networks and develop strategic accounts, ensuring a superior customer experience that...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$192K - $278K *

Support the development and leadership of a security incident response team, focusing on enhancing automation, program maturity, and cross-functional collaboration to ensure effective incident managem...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $180K *

Shape the future of AI Cybersecurity by providing technical leadership in evaluating, implementing, and operationalizing AI security solutions to protect against emerging threats while ensuring compli...

Washington, USRemote

4 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$123K - $164K *

Lead software quality assurance initiatives, driving testing strategies and team development to ensure high-quality software solutions. Collaborate across teams to enhance quality practices and suppor...

RemoteRemote

Yesterday

  •   8 - 10 years exp.  •   Healthcare

$124K - $207K *

Join our team to design and implement secure customer identity solutions using Auth0 and Okta. Collaborate with development teams to enhance identity management through automation, ensuring seamless s...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$150K - $175K *

Elevate your career by leading a high-performing Security Engineering and CloudSecOps team. Drive security initiatives across cloud and enterprise environments, ensuring compliance and resilience whil...

United StatesRemote

5 days ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $154K *

Champion your career by managing change orders for large projects, evaluating contractual impacts, and ensuring effective communication with stakeholders. Collaborate with diverse teams to drive succe...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$100K - $120K *

Manage the end-to-end SIT testing strategy, leading QA teams and ensuring quality across projects. Collaborate with stakeholders to develop test plans, oversee execution, and drive continuous improvem...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Staffing

$110K - $130K *

Unlock potential by leveraging your Salesforce expertise to design, build, and review secure, scalable solutions. Collaborate with clients and teams to ensure seamless integrations and effective deliv...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Enterprise Technology

$101K - $188K *

Drive the innovation of semi- and fully autonomous systems. Engage in research, algorithm development, and optimization to enhance AI and machine learning applications for diverse mission challenges...

Three Rivers, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$125K - $150K *

Elevate customer experiences by leading a team of engineers, providing strategic insights, and implementing innovative solutions in growth engineering and digital marketing for impactful delivery serv...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$85K - $148K *

Manage storage infrastructure for DASD and tape systems, ensuring optimal performance and reliability. Oversee customer migrations, backups, and disaster recovery, while providing expert support and m...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$157K - $238K *

Join a dynamic team to leverage AI in enhancing application security. You'll assess vulnerabilities, implement fixes, and shape AI security strategies, driving innovation in a fast-paced environment w...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$83K - $115K *

Transform service delivery by leading a skilled team of engineers, ensuring operational excellence and customer satisfaction through effective coordination and relationship management. Drive continuou...

RemoteRemote

Yesterday

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $120K *

Drive operational excellence as a trusted advisor, managing high-impact client accounts to translate complex data into strategic insights, guiding executive decision-making, and fostering client relat...

United StatesRemote

Reposted 3 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join a team that's dedicated to enhancing healthcare interoperability. Utilize your expertise to troubleshoot and provide technical support for EHR, HIE, FHIR, and API services, ensuring seamless inte...

Austin, TXRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Champion a robust DevOps culture, leading a dynamic team while enhancing cloud infrastructure and processes for reliability, security, and cost efficiency. Drive innovation and accountability through...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$104K - $166K *

Engineer robust AWS cloud infrastructure, ensuring performance and scalability. Collaborate with cross-functional teams to optimize analytics solutions, automate processes, and provide technical suppo...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$110K - $130K *

Unlock your potential as a key player in optimizing EPIC applications, leading complex projects, and enhancing user experience in healthcare IT. Collaborate with stakeholders to deliver innovative sol...

Chicago, ILRemote

2 weeks ago

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$130K - $160K *

Lead the engineering of cutting-edge SIEM and SOAR platforms while advising clients on enhancing their security posture. Your expertise will shape customer onboarding and service design, ensuring effe...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$170K - $240K *

Unlock your potential by leading a team focused on enterprise authentication security. Drive innovation in single sign-on platforms, ensuring secure, scalable solutions for millions of users while fos...

Georgia, USRemote

5 days ago

  •   8 - 10 years exp.  •   Retail & Consumer Goods

$90K - $110K *

Partner with us to ensure the quality and reliability of our web-based administrative solutions. Collaborate with cross-functional teams to validate features, identify defects, and maintain comprehens...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$115K - $125K *

Champion operational excellence by managing cross-regional teams, ensuring consistent performance standards, and facilitating effective agent execution. Drive strategic initiatives and resolve conflic...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.