Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$116K - $133K *

Join a team that's dedicated to enhancing security for thousands of customers. As an intern, you'll tackle real security challenges, build valuable tools, and collaborate with top engineers under expe...

RemoteRemote

1 month ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $130K *

Oversee the entire contract lifecycle, ensuring swift execution while managing risk. Collaborate cross-functionally to negotiate terms and enhance processes, directly impacting revenue and vendor perf...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Shape the future of AI integration by leading complex projects, bridging technical teams and leadership. Drive Agile methodologies, manage risks, and ensure timely deliverables in a dynamic environmen...

Virginia, USRemote

3 days ago

  •   8 - 10 years exp.  •   Information Technology

$140K - $175K *

Elevate your career by leading technology integration for M&A, ensuring seamless execution from due diligence to stabilization. Drive cross-functional collaboration and deliver predictable outcomes wh...

St. Louis, MORemote

4 days ago

  •   8 - 10 years exp.  •   Finance & Insurance

$100K - $140K *

Transform data into actionable insights by collaborating with leadership to analyze, visualize, and communicate findings. Leverage expertise in business intelligence tools to enhance decision-making f...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$145K - $170K *

Transform critical government missions by providing hands-on engineering support for enterprise infrastructure, cloud services, and virtualization. Collaborate with diverse teams to ensure the securit...

Washington DC, USRemote

2 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$95K - $115K *

Transform healthcare billing by leading a dedicated Hospital Billing Claims team, enhancing claims accuracy, regulatory compliance, and team performance while collaborating with partners to deliver op...

Pittsburgh, PARemote

Reposted yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$95K - $115K *

Lead the charge in optimizing hospital billing processes by guiding a skilled claims team. Drive improvements in claims management, regulatory updates, and collaboration with professional billing to e...

Pittsburgh, PARemote

Reposted yesterday

  •   5 - 7 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Champion continuous process improvement and organizational redesign, providing expert analysis and guidance to enhance business processes. Collaborate with cross-functional teams to implement effectiv...

Texas, USRemote

1 week ago

  •   15+ years exp.  •   Information Technology

$69K - $125K *

Join a team that's pivotal in supporting the FAA's new Air Traffic Control System. As an RSR Field Engineer, you'll oversee installations at critical airports, ensuring timely execution and high-quali...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Technical Services

$212K - $345K *

Elevate sales performance by leading a dynamic team in Governance, Risk & Compliance. Drive strategic initiatives, foster collaboration, and ensure exceptional customer experiences while achieving gro...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Consumer Technology

$104K - $166K *

Drive modernization efforts in America's airspace by ensuring accurate software installations and configurations for the FAA's Terminal Flight Data Manager program. Collaborate with teams to resolve t...

United StatesRemote

4 days ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$149K - $230K *

Champion innovative solutions by partnering with Sales to address complex security challenges. Serve as a trusted advisor, leading technical discovery and delivering impactful demonstrations that conn...

Sacramento, CARemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$157K - $298K *

Join a team that's committed to operational excellence through leadership of the Enterprise Quality Audit team, driving compliance, continuous improvement, and quality governance across business units...

California, USRemote

Reposted 2 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$180K - $220K *

Unlock potential by leading software systems management and optimization across a global portfolio. Collaborate with business and technology leaders to enhance operational efficiency, drive innovation...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Education, Government & Non-Profit

$190K - $225K *

Join a team that's dedicated to shaping the future of identity management by leading security strategies, architecting robust solutions, and optimizing user access processes in a dynamic, tech-driven...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$140K - $160K *

Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$110K - $130K *

Analyze cybersecurity risks and enhance client maturity through assessments, incident response strategies, and developing tailored recommendations. Collaborate with stakeholders while managing multipl...

Washington, DCRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$222K - $303K *

Drive compliance and quality oversight in pharmacovigilance, ensuring regulatory readiness and continuous improvement. Collaborate with leadership to enhance monitoring, training, and governance, fost...

New Jersey, USRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$150K - $180K *

Shape the future of security by leading our first dedicated security function. You'll build and execute a comprehensive security program, ensuring safe AI adoption while protecting sensitive health da...

United StatesRemote

3 days ago

  •   8 - 10 years exp.  •   Healthcare

$95K - $115K *

Deliver innovative Appian solutions by developing, enhancing, and maintaining applications while supporting modernization initiatives in a collaborative Agile environment. Troubleshoot issues and ensu...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Information Technology

$116K - $187K *

Lead the charge in integrating healthcare systems, ensuring secure data exchange across platforms. Drive interoperability initiatives, optimize APIs, and enhance clinical data capabilities while suppo...

Providence, RIRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$105K - $115K *

Transform system integrations and testing practices in an Agile team, enhancing user experiences and supporting cutting-edge LMR technology solutions for community safety, while advancing your technic...

RemoteRemote

3 weeks ago

  •   Less than 5 years exp.  •   Telecommunications & Hardware

$139K - $213K *

Drive relationships and sales success by positioning technology solutions within the U.S. Army. Leverage existing networks and develop strategic accounts, ensuring a superior customer experience that...

United StatesRemote

1 month ago

  •   5 - 7 years exp.  •   Information Technology

$192K - $278K *

Support the development and leadership of a security incident response team, focusing on enhancing automation, program maturity, and cross-functional collaboration to ensure effective incident managem...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.