Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
Security Engineer Intern, 2027 Summer U.S.
$116K - $133K *
Join a team that's dedicated to enhancing security for thousands of customers. As an intern, you'll tackle real security challenges, build valuable tools, and collaborate with top engineers under expe...
1 month ago
Senior Manager, Contracts & Legal (Remote)
$120K - $130K *
Oversee the entire contract lifecycle, ensuring swift execution while managing risk. Collaborate cross-functionally to negotiate terms and enhance processes, directly impacting revenue and vendor perf...
2 days ago
$110K - $130K *
Shape the future of AI integration by leading complex projects, bridging technical teams and leadership. Drive Agile methodologies, manage risks, and ensure timely deliverables in a dynamic environmen...
3 days ago
Director, Technology Integration Delivery
$140K - $175K *
Elevate your career by leading technology integration for M&A, ensuring seamless execution from due diligence to stabilization. Drive cross-functional collaboration and deliver predictable outcomes wh...
4 days ago
Business Data Analyst (Remote)
$100K - $140K *
Transform data into actionable insights by collaborating with leadership to analyze, visualize, and communicate findings. Leverage expertise in business intelligence tools to enhance decision-making f...
Yesterday
Senior Infrastructure & Cloud Engineer (IaaS)
$145K - $170K *
Transform critical government missions by providing hands-on engineering support for enterprise infrastructure, cloud services, and virtualization. Collaborate with diverse teams to ensure the securit...
2 weeks ago
Systems Analyst - Team Lead (Epic HB Claims and Remittance)
$95K - $115K *
Transform healthcare billing by leading a dedicated Hospital Billing Claims team, enhancing claims accuracy, regulatory compliance, and team performance while collaborating with partners to deliver op...
Reposted yesterday
Systems Analyst - Team Lead (Epic HB Claims and Remittance)
$95K - $115K *
Lead the charge in optimizing hospital billing processes by guiding a skilled claims team. Drive improvements in claims management, regulatory updates, and collaboration with professional billing to e...
Reposted yesterday
$110K - $130K *
Champion continuous process improvement and organizational redesign, providing expert analysis and guidance to enhance business processes. Collaborate with cross-functional teams to implement effectiv...
1 week ago
$69K - $125K *
Join a team that's pivotal in supporting the FAA's new Air Traffic Control System. As an RSR Field Engineer, you'll oversee installations at critical airports, ensuring timely execution and high-quali...
3 weeks ago
Sales Manager - Governance, Risk & Compliance
$212K - $345K *
Elevate sales performance by leading a dynamic team in Governance, Risk & Compliance. Drive strategic initiatives, foster collaboration, and ensure exceptional customer experiences while achieving gro...
1 week ago
$104K - $166K *
Drive modernization efforts in America's airspace by ensuring accurate software installations and configurations for the FAA's Terminal Flight Data Manager program. Collaborate with teams to resolve t...
4 days ago
Sr Advisory Solution Architect - Government Healthcare and Education (Armis/Veza)
$149K - $230K *
Champion innovative solutions by partnering with Sales to address complex security challenges. Serve as a trusted advisor, leading technical discovery and delivering impactful demonstrations that conn...
2 days ago
Associate Director, Quality System Compliance (Remote)
$157K - $298K *
Join a team that's committed to operational excellence through leadership of the Enterprise Quality Audit team, driving compliance, continuous improvement, and quality governance across business units...
Reposted 2 weeks ago
Head of Software Systems & Business Enablement
$180K - $220K *
Unlock potential by leading software systems management and optimization across a global portfolio. Collaborate with business and technology leaders to enhance operational efficiency, drive innovation...
1 week ago
Sr. Manager, Identity and Access Management
$190K - $225K *
Join a team that's dedicated to shaping the future of identity management by leading security strategies, architecting robust solutions, and optimizing user access processes in a dynamic, tech-driven...
4 weeks ago
CCaR - Senior Software Engineer (Remote)
$140K - $160K *
Drive the development of critical enterprise applications for DoD personnel, enhancing program and financial management capabilities. Collaborate within a product team to modernize technology and deli...
Today
Senior Risk Advisory Consultant - Remote (USA)
$110K - $130K *
Analyze cybersecurity risks and enhance client maturity through assessments, incident response strategies, and developing tailored recommendations. Collaborate with stakeholders while managing multipl...
Reposted 3 weeks ago
Senior Director, DSPV Quality, Training & Compliance
$222K - $303K *
Drive compliance and quality oversight in pharmacovigilance, ensuring regulatory readiness and continuous improvement. Collaborate with leadership to enhance monitoring, training, and governance, fost...
Reposted today
$150K - $180K *
Shape the future of security by leading our first dedicated security function. You'll build and execute a comprehensive security program, ensuring safe AI adoption while protecting sensitive health da...
3 days ago
$95K - $115K *
Deliver innovative Appian solutions by developing, enhancing, and maintaining applications while supporting modernization initiatives in a collaborative Agile environment. Troubleshoot issues and ensu...
4 days ago
Lead Clinical Data Integration & Interoperability
$116K - $187K *
Lead the charge in integrating healthcare systems, ensuring secure data exchange across platforms. Drive interoperability initiatives, optimize APIs, and enhance clinical data capabilities while suppo...
1 week ago
Systems Specialist - Radio Online Application (US Remote)
$105K - $115K *
Transform system integrations and testing practices in an Agile team, enhancing user experiences and supporting cutting-edge LMR technology solutions for community safety, while advancing your technic...
3 weeks ago
Director of Strategic Accounts - U.S. ARMY
$139K - $213K *
Drive relationships and sales success by positioning technology solutions within the U.S. Army. Leverage existing networks and develop strategic accounts, ensuring a superior customer experience that...
1 month ago
Manager, Security Incident Response
$192K - $278K *
Support the development and leadership of a security incident response team, focusing on enhancing automation, program maturity, and cross-functional collaboration to ensure effective incident managem...
Reposted 3 weeks ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.