Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$180K - $281K *

Join a team that's driving transformative customer success by leveraging ServiceNow solutions. As a strategic advisor, you'll enhance client relationships, optimize platform value, and ensure satisfac...

Vienna, VARemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$150K - $180K *

Shape the future of security by leading cross-functional initiatives to enhance incident detection and response capabilities. Collaborate with diverse teams to identify risks, develop automation, and...

RemoteRemote

2 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$160K - $200K *

Drive the development of cutting-edge AI systems by leveraging your expertise in Go and Python. Collaborate cross-functionally to optimize and refine scalable services, ensuring high performance and u...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Enterprise Technology

$132K - $150K *

Elevate the Technical Support transformation by driving strategic initiatives across Customer Experience. Own the execution of comprehensive plans, manage vital partnerships, and ensure success throug...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$121K - $161K *

Transform your career by leading the design and implementation of Veeva Vault RIM, ensuring optimal performance and compliance while collaborating with cross-functional teams to enhance user experienc...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$100K - $170K *

Partner with us to enhance our cybersecurity posture by leading attack surface management initiatives, identifying vulnerabilities, and driving remediation strategies that align with business risk and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Finance & Insurance

$130K - $140K *

Support the Project Manager in executing complex VA initiatives, ensuring effective coordination and communication across teams. Drive strategic direction into actionable plans while adapting to evolv...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$102K - $174K *

Join a team that's redefining user experiences in Robotics and Autonomous Systems. As a UI/UX Designer, you'll create intuitive interfaces, conduct user research, and collaborate with developers to de...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Business Services

$69K - $144K *

Unlock the potential of technology risk management by assessing controls, ensuring SOX compliance, and providing expert advisory for system implementations. Drive audit effectiveness while partnering...

Dallas, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$74K - $89K *

Elevate healthcare quality by reviewing medical records, ensuring accurate coding, and maintaining compliance with guidelines. Collaborate with teams to enhance coding practices and uphold high standa...

United StatesRemote

3 days ago

  •   Less than 5 years exp.  •   Information Technology

$198K - $298K *

Champion the optimization of Sales systems and processes, driving productivity and strategic initiatives. Collaborate with cross-functional teams to enhance the sales experience and lead a global team...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$91K - $110K *

Elevate employee benefits by designing and managing comprehensive health, welfare, and retirement programs. Collaborate with stakeholders to ensure compliance, optimize costs, and enhance coworker exp...

Illinois, USRemote

Yesterday

  •   5 - 7 years exp.  •   Information Technology

$100K - $125K *

Join a team that's dedicated to crafting compelling federal proposals, managing the full lifecycle from inception to submission. Collaborate with experts to deliver high-quality technical narratives t...

Alexandria, VARemote

3 weeks ago

  •   5 - 7 years exp.  •   Aerospace & Defense

$120K - $145K *

Elevate security and efficiency in cloud environments by designing and automating secure CI/CD pipelines, ensuring compliance and reliability for regulated applications in a FedRAMP High setting, whil...

Dallas, TXRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $120K *

Join a dynamic team to drive strategic contracts management and proposal development for high-stakes federal bids. Collaborate across functions to balance risk and compliance while ensuring financial...

Alabama, USRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$120K - $145K *

Champion strategic contract management and proposal development for high-stakes federal bids. Collaborate across teams to balance risk and compliance while driving growth through effective negotiation...

Alabama, USRemote

1 week ago

  •   8 - 10 years exp.  •   Information Technology

$95K - $115K *

Join a dynamic team to enhance Epic HB Claims applications, driving innovative solutions and optimizing workflows. Collaborate with stakeholders to ensure successful implementation and provide expert...

San Antonio, TXRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Join a dynamic team as a Mid Systems Engineer, contributing to the full lifecycle of systems engineering projects. Collaborate with cross-functional teams to solve complex technical challenges and ens...

Orlando, FLRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $140K *

Drive compliance excellence as a Senior Compliance Program Manager, overseeing complex initiatives across enterprise and federal environments. Collaborate with cross-functional teams to ensure audit r...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$95K - $115K *

Unlock the potential of IT modernization by crafting compelling executive briefings. Collaborate with technical teams to translate cloud infrastructure insights into clear narratives for government le...

Ashburn, VARemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Information Technology

$95K - $125K *

Advance your career by coordinating healthcare technology integration across multiple VA sites. Leverage your project management skills to support the Federal Electronic Health Record Modernization pr...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$143K - $230K *

Elevate your career by driving sales growth in Governance, Risk, and Compliance solutions. Collaborate with executive-level clients to identify needs, present tailored solutions, and close deals, all...

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2 weeks ago

  •   Less than 5 years exp.  •   Consumer Technology

$68K - $112K *

Take ownership of enterprise networking solutions, delivering high-quality consulting and implementation services. Collaborate with teams to design, implement, and support complex network environments...

CanadaRemote

3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$135K - $160K *

Design and oversee tailored security architectures for government clients, ensuring integration of threat intelligence and compliance within Cyware's platform. Collaborate on use cases, empower teams...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$131K - $187K *

Lead the evolution of secure software engineering by integrating security into design, development, and delivery processes. Collaborate with cross-functional teams to implement secure practices and dr...

United StatesRemote

3 days ago

  •   5 - 7 years exp.  •   Consumer Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.