Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$110K - $130K *

Champion your career in cybersecurity by enhancing threat detection and response capabilities in a dynamic environment. Collaborate closely with security teams to establish and improve cyber threat in...

Pennsylvania, USRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $150K *

Lead the strategic alignment of R&D and IT, ensuring compliance and scalability of Veeva systems. Drive technology roadmaps, manage vendor relationships, and mentor junior partners while enhancing reg...

United StatesRemote

Reposted 3 days ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$145K - $185K *

Champion new business opportunities by building relationships, shaping solutions, and leading contract execution within the Army sector. Drive portfolio growth while ensuring customer satisfaction and...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$130K - $150K *

Lead the charge in driving impactful cybersecurity and AI risk programs, managing multidisciplinary teams, and translating complex findings into executive insights while fostering client relationships...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$135K - $160K *

Elevate cybersecurity by designing and implementing robust security protocols, ensuring compliance across cloud infrastructure while managing IAM, PKI, and secrets management to protect fintech worklo...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$135K - $160K *

Shape the future of cloud security by architecting and implementing robust controls across multi-region AWS environments, ensuring compliance and maintaining high security standards for fintech worklo...

New York, NYRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$120K - $145K *

Lead robust cloud infrastructure solutions in AWS and AWS GovCloud, ensuring CI/CD and security compliance across environments. Collaborate with teams to optimize deployment and operational processes...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$103K - $139K *

Elevate business processes by leading SAP Sales and Distribution solutions. Collaborate with stakeholders to analyze, design, and implement integrated systems, ensuring effective communication and pro...

RemoteRemote

3 days ago

  •   8 - 10 years exp.  •   Manufacturing & Automotive

$125K - $150K *

Transform client relationships and drive business growth through strategic sales execution in Application Modernization Services. Leverage industry expertise and AI knowledge to deliver tailored solut...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Technical Services

$125K - $150K *

Drive secure network segmentation by designing and managing compliant architectures. Leverage advanced security tools to ensure policy-driven connectivity across global environments while leading oper...

Georgia, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $185K *

Champion growth by leading business development within the Intelligence Community. Build relationships, shape solutions, and ensure contract success while managing a diverse portfolio and driving team...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Information Technology

$150K - $200K *

Lead high-impact client delivery operations, ensuring quality execution and resource optimization across diverse projects. Collaborate with cross-functional teams to drive performance and enhance cust...

United StatesRemote

Yesterday

  •   8 - 10 years exp.  •   Enterprise Technology

$106K - $143K *

Develop and maintain innovative Oracle applications, driving modernization and excellence in software development. Collaborate with teams to enhance grants management systems and ensure effective appl...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$128K - $250K *

Join a dynamic team to drive Cyber Security solutions for Fortune 2000 clients. You'll manage client relationships, lead sales initiatives, and oversee the entire deal lifecycle, ensuring value-driven...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$80K - $95K *

Transform identity and access management by executing daily operations, supporting AI tooling, and managing SaaS vendor administration. This role offers hands-on experience and a clear growth path tow...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$104K - $166K *

Oversee the management of databases on z/OS while providing technical development support for a Department of Defense customer. Collaborate with teams to modernize and maintain intricate mainframe sys...

United StatesRemote

Reposted 4 weeks ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$215K - $235K *

Lead the charge in building a robust partner ecosystem for defense contractors, driving revenue through MSSPs, MSPs, RPOs, and C3PAOs. Own partner recruitment, enablement, and success, while collabora...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$75K - $158K *

Support the evolution of Oracle EPM solutions, enhancing business operations through requirements gathering, configuration, and collaboration to drive improvements for military and civilian agencies...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Champion the proposal management process by leading complex RFP responses, ensuring compliance and quality. Collaborate with cross-functional teams to deliver compelling proposals that align with stra...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Aerospace & Defense

$81K - $116K *

Elevate business processes by analyzing and optimizing vendor integrations, collaborating closely with cross-functional teams to enhance product delivery and streamline operational efficiency in a rem...

Montreal, QCRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$131K - $172K *

Drive impactful security solutions by leading engagements, delivering expertise, and fostering customer relationships. Collaborate across teams to enhance security practices and ensure optimal deploym...

Ann Arbor, MIRemote

3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$132K - $185K *

Shape the future of cybersecurity by leading security engagements, delivering solutions, and providing expert support to customers. Collaborate with teams to design, deploy, and optimize Cisco Securit...

Ann Arbor, MIRemote

3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$118K - $125K *

Advance your career by leading a dynamic SOC team, mentoring analysts, and managing complex security incidents. Collaborate with cross-functional teams to enhance operations and protect top organizati...

Tampa, FLRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $128K *

Transform the future of air traffic management by ensuring seamless software installations and operational readiness for FAA's Terminal Flight Data Manager program, while collaborating with teams acro...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $90K *

Engage in data analysis and communications to support strategic planning and policy review for federal programs. Collaborate with stakeholders to ensure timely responses and effective execution of hig...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.