Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.
Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.
Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.
ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.
Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.
$75K - $158K *
Join a dynamic team to develop and maintain analytics for a federal HCM modernization program, focused on delivering real-time insights and compliance reporting using Oracle BI tools and ensuring acce...
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$90K - $189K *
Join a dynamic team to architect and deliver analytics solutions that empower federal HR leaders through innovative dashboards, compliance reporting, and predictive models, contributing to a significa...
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Principal Consultant - HCM Training Developer & Instructional Design
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Lead the development and delivery of training programs for Oracle Fusion Cloud HCM, impacting federal HR operations and enhancing user adoption across agencies. Utilize instructional design expertise...
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Join a team that's bridging clinical healthcare and operational readiness, focusing on military health policy and program execution. Leverage your expertise in traumatic brain injury and clinical guid...
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$144K - $188K *
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Join a team that's shaping the future of government tech solutions. Lead and innovate within a dedicated engineering team, delivering high-quality software in a dynamic environment while collaborating...
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$110K - $138K *
Drive cybersecurity excellence by assessing and securing technology environments during mergers and acquisitions, ensuring compliance and integration of critical systems across diverse platforms...
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Healthcare Regulatory Assurance Lead
$119K - $175K *
Optimize healthcare compliance by leading regulatory assurance efforts, ensuring adherence to HIPAA, HITECH, and HITRUST standards while collaborating with clinical leadership to maintain a defensible...
3 days ago
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$143K - $176K *
Join a team that's driving innovation in project management and Agile delivery. Lead cross-functional teams to achieve program objectives while enhancing your skills in a dynamic environment focused o...
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Engineer innovative ERP solutions by customizing modules, integrating features, and enhancing system performance. Collaborate with stakeholders to align business objectives with technical capabilities...
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CDO-L Study Lead Engineer (REMOTE)
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Drive the advancement of enterprise Identity, Credential, and Access Management (ICAM) capabilities in contested environments, leading technical studies and architectural development to enhance operat...
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Senior Counsel - Data Governance, Privacy and Cybersecurity
$119K - $186K *
Advance your career by providing strategic legal counsel on data governance, privacy, and cybersecurity within a dynamic healthcare environment. Collaborate with cross-functional teams to drive compli...
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$88K - $154K *
Join a dynamic team as a Document Control Supervisor, overseeing document management for construction and engineering projects. Drive process improvements, ensure compliance, and support project teams...
2 weeks ago
Senior MSSP Partner Contracts Manager
$132K - $182K *
Shape the future of MSSP partner agreements by modernizing frameworks, guiding negotiations, and collaborating with cross-functional teams to enhance revenue strategies and streamline contract process...
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$110K - $130K *
Oversee the implementation and onboarding process for multiple client partners, ensuring a seamless experience from contract execution to go-live while collaborating cross-functionally to drive succes...
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Join a team that's dedicated to enhancing client success through effective onboarding and implementation of our innovative platform. Collaborate cross-functionally to ensure a seamless experience for...
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Director, Professional Services - Cybersecurity
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Transform cybersecurity professional services by leading delivery execution, ensuring quality, and developing talent. Collaborate with cross-functional teams to enhance service capabilities and drive...
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Unlock your potential as a senior technical contributor, leading infrastructure design and implementation. Drive strategic decisions, mentor junior engineers, and enhance system performance in a dynam...
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$135K - $165K *
Lead the charge in advancing military technologies through innovative remote sensing analysis, collaborating with diverse teams to evaluate and synthesize critical information for strategic decision-m...
2 weeks ago
Senior Cloud Security Engineer
$135K - $160K *
Accelerate progress at securing cloud environments by designing robust guardrails and automation. Collaborate with engineering teams to embed security into CI/CD pipelines and ensure compliance across...
4 days ago
$140K - $165K *
Join a team that's redefining security architecture by enhancing existing systems, developing new functionalities, and ensuring robust protection across cloud infrastructures. Collaborate with enginee...
3 weeks ago
Medical Information Specialist
$80K - $95K *
Unlock potential by delivering expert medical information support to healthcare professionals, ensuring safe product use through timely, evidence-based responses and effective communication across mul...
1 week ago
What is an Information Systems Security Officer (ISSO)?
An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.
What qualifications are commonly required for ISSO jobs?
Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.
How much do Information Systems Security Officers earn?
Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.
Where do ISSOs work?
ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.
How can I find ISSO jobs paying $100,000 or more?
Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.