Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$125K - $150K *

Join our team as a Security Architect, where you'll collaborate across technical and business domains to enhance security during mergers and acquisitions, ensuring robust protection and seamless integ...

Raleigh, NCRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$130K - $155K *

Unlock potential by leading security architecture for mergers and acquisitions. Collaborate with cross-functional teams to design and implement security solutions, ensuring seamless integration and ri...

Atlanta, TXRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$125K - $150K *

Champion security excellence by leading strategic initiatives in mergers and acquisitions. Collaborate across teams to design and implement robust security solutions, ensuring seamless integration and...

Durham, NCRemote

2 weeks ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$132K - $185K *

Shape the future of cybersecurity by leading security consulting engagements, designing and implementing Cisco Security Solutions, and driving customer success through expert guidance and innovative s...

North Carolina, USRemote

3 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$135K - $251K *

Join a team that's shaping the future of software development by enhancing DevSecOps capabilities. Collaborate with customers to automate processes and deliver innovative solutions in a dynamic enviro...

Pennsylvania, USRemote

1 week ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$130K - $175K *

Transform IT operations by establishing automated, self-service systems while ensuring ISO compliance. As a crucial partner across functions, you'll enhance security protocols, streamline workflows, a...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$143K - $174K *

Empower teams by managing complex IT systems and programs, leading projects, and ensuring robust infrastructure. Leverage expertise to enhance multi-departmental functions through strategic planning a...

Fairfield, CARemote

4 weeks ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$160K - $200K *

Drive customer success by leading strategic transformations and fostering C-suite relationships. Leverage ServiceNow expertise to enhance satisfaction, retention, and value delivery across complex, mu...

Addison, TXRemote

1 week ago

  •   11 - 15 years exp.  •   Information Technology

$100K - $120K *

Engage in shaping compliance strategies within a dynamic regulatory environment. Collaborate with cross-functional teams to assess risks, support regulatory exams, and implement effective solutions th...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Finance & Insurance

$112K - $193K *

Lead the charge in strategic M&A cybersecurity due diligence, driving complex initiatives from inception to completion and ensuring informed acquisition decisions while safeguarding enterprise data an...

Eden Prairie, MNRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$116K - $210K *

Elevate manufacturing capabilities by leading enterprise MES initiatives, ensuring system performance, configuration, and integration while driving continuous improvement and technical expertise acros...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Technical Services

$165K - $248K *

Lead enterprise-scale operations for cloud services, ensuring performance and customer satisfaction. Drive a multidisciplinary team, manage service transitions, and leverage data-driven metrics to enh...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$84K - $124K *

Drive the evolution of Cyber Defense by engineering and automating security operations, enhancing incident response, and maintaining enterprise security platforms to ensure robust protection and swift...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$117K - $176K *

Lead the optimization and administration of advanced imaging solutions in a dynamic healthcare setting, enhancing workflows and collaborating with diverse teams to deliver innovative and efficient ser...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$150K - $275K *

Unlock potential by leading enterprise networking solutions, guiding teams through complex architectures, and translating business needs into scalable strategies. Collaborate with stakeholders to ensu...

Texas, USRemote

Today

  •   11 - 15 years exp.  •   Technical Services

$130K - $170K *

Elevate employee experiences by leading the design and implementation of integrated HR Service Delivery solutions leveraging ServiceNow and Microsoft technologies...

Virginia, USRemote

4 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Join us to lead comprehensive audits and compliance reviews, ensuring adherence to federal and state regulations while enhancing operational effectiveness across various departments. Drive risk assess...

Galveston, TXRemote

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$68K - $143K *

Analyze and reengineer business processes to enhance operational efficiency, collaborating with stakeholders to ensure alignment with strategic goals and regulatory requirements while supporting syste...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$93K - $155K *

Join a team that's driving the future of cybersecurity by leading technical security control initiatives. Your expertise will shape enterprise security across multiple domains, ensuring effective cont...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Finance & Insurance

$110K - $130K *

Lead the charge in optimizing healthcare processes for the Veterans Health Administration, enhancing business and clinical operations. Collaborate with stakeholders to redesign workflows, address chal...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $150K *

Lead the charge in strategic enterprise sales, managing complex accounts and building C-suite relationships to drive long-term revenue across key verticals. Navigate intricate sales cycles and complia...

Tampa, FLRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$57K - $104K *

Transform cloud infrastructure by supporting AWS operations, automation, and modernization. Collaborate with senior engineers to enhance security, troubleshoot issues, and improve processes while deve...

United StatesRemote

Reposted yesterday

  •   Less than 5 years exp.  •   Technical Services

$59K - $106K *

Champion the administration of Azure Virtual Desktop environments, ensuring optimal performance and security. Collaborate with teams to support M365 platforms and provide technical guidance, enhancing...

Suffolk, VARemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$92K - $153K *

Lead the charge in transforming client operations through innovative ServiceNow solutions. Collaborate with stakeholders and technical teams to streamline processes, enhance functionalities, and ensur...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$100K - $120K *

Transform client operations into scalable systems by leading discovery, designing workflows, and ensuring project success. Collaborate with engineers to deliver tailored solutions that enhance efficie...

CanadaRemote

1 week ago

  •   Less than 5 years exp.  •   Enterprise Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.