Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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$110K - $130K *

Inspire the evolution of commercial systems, enhancing integration and automation across platforms like Salesforce and HubSpot. Drive AI adoption to streamline workflows, ensuring data integrity and r...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $240K *

Elevate your career by leading a dynamic security research team focused on innovative data collection and analysis methodologies, driving strategic technology investments, and shaping the future of se...

Boston, MARemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$75K - $120K *

Advance your career by implementing innovative SaaS solutions, configuring custom workflows, and driving system integration projects. Collaborate with a dynamic team to tackle complex challenges and d...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$90K - $189K *

Elevate your career as a ServiceNow Business Analyst, bridging data analysis and IT modernization. Collaborate with stakeholders to optimize workflows and enhance performance outcomes through actionab...

United StatesRemote

4 days ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $95K *

Elevate your career as a Document Control Supervisor, overseeing site access agreements and collaborating with environmental consulting teams. Utilize your expertise to resolve access needs, manage do...

Long Beach, CARemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Champion effective document control by overseeing site access agreements, resolving access issues, and coordinating with environmental consulting teams. Lead a team while ensuring compliance and effic...

Denver, CORemote

1 week ago

  •   5 - 7 years exp.  •   Real Estate & Construction

$88K - $105K *

Elevate procurement efficiency by supporting contract operations, developing documentation, and liaising with stakeholders. Play a key role in ensuring compliance with regulations while managing compl...

Silver Spring, MDRemote

5 days ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$135K - $145K *

Join a team that's transforming healthcare by leading VistA application transitions. Leverage your expertise to analyze, plan, and execute modernization efforts, ensuring seamless deployment and opera...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$67K - $108K *

Explore a dynamic role supporting outside plant projects, ensuring material accuracy and inventory management. Collaborate with teams to enhance processes and track construction milestones while maint...

Appleton, WIRemote

3 days ago

  •   Less than 5 years exp.  •   Technical Services

$100K - $130K *

Drive the design and deployment of secure AI applications in cloud environments, integrating advanced technologies like machine learning and ServiceNow solutions to enhance operational efficiency and...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Information Technology

$65K - $123K *

Champion premium software support for mainframe clients, focusing on CICS and WAS. Drive installations, testing, and maintenance of systems software while ensuring timely customer service and effectiv...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$145K - $193K *

Lead a dynamic team of technical experts to design and deliver innovative consulting services and educational programs, ensuring alignment with evolving product strategies and maintaining high standar...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Enterprise Technology

$82K - $172K *

Design and implement innovative AI solutions, guiding pilot programs from conception to execution while collaborating across teams to enhance system capabilities and performance in a dynamic environme...

United StatesRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Information Technology

$80K - $114K *

Unlock potential by applying technical expertise to solve complex problems, collaborating across teams, and developing event-driven applications. Engage in project work that enhances system efficiency...

Ohio, USRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$110K - $130K *

Develop and enhance security systems through analytics and reporting. Manage access, respond to inquiries, and ensure operational support during on-call shifts. Collaborate across teams to drive secur...

Oak Brook, ILRemote

2 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $175K *

Shape the future of defense solutions by leveraging C5ISR expertise to develop mission-focused strategies for the U.S. Army and Department of War, ensuring alignment with customer priorities and acqui...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$90K - $189K *

Join a dynamic team to lead enterprise-level Oracle Fusion Cloud HCM customizations, designing ETL pipelines and guiding migrations for federal agencies. Your expertise will ensure data integrity and...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$120K - $145K *

Shape the future of patient services by ensuring timely delivery of features and integrations. Collaborate across teams to enhance operational efficiency in a compliance-heavy environment, driving inn...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$80K - $90K *

Analyze and deliver data management solutions to support public health research, utilizing advanced statistical software and collaborating with project leaders to enhance data quality and reporting fo...

Massachusetts, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$110K - $130K *

Shape the future of messaging systems by managing IBM MQ clusters, automating tasks, and ensuring optimal performance. Collaborate with teams to enhance file transfer solutions and troubleshoot comple...

Connecticut, USRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$75K - $158K *

Join a dynamic team to develop RPA solutions using UiPath and Java technologies. Engage with stakeholders to implement automation solutions that enhance workflows while working on cutting-edge project...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$150K - $160K *

Drive project success by managing integrated delivery across AI task orders, overseeing multidisciplinary teams, and ensuring adherence to quality standards while maintaining project roadmaps and sche...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $189K *

Drive the transformation of federal HR systems by leading the functional design of Oracle Fusion Cloud HCM modules, collaborating with stakeholders to deliver modern, efficient solutions for millions...

RemoteRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $157K *

Unlock potential by designing and delivering innovative RPA solutions using UiPath. Collaborate with cross-functional teams to enhance automation processes, ensuring high-quality outcomes and adherenc...

United StatesRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Information Technology

$94K - $157K *

Engineer and deliver innovative RPA solutions using UiPath, collaborating across teams to meet organizational needs. This role requires hands-on expertise, commitment to quality, and participation in...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.