Information Systems Security Officer (ISSO) Jobs

Information Systems Security Officers help organizations protect sensitive data, systems, and networks. ISSOs assess security risks, guide teams through compliance requirements, and help ensure that information systems are designed and operated securely. Explore vetted ISSO opportunities on Ladders, including professional roles that pay $100,000 or more.

What Does an ISSO Do?

Responsibilities vary by employer and industry, but ISSOs commonly maintain security documentation, monitor system controls, coordinate risk assessments, and support authorization and compliance activities. They may work with system owners, security engineers, auditors, and government stakeholders to identify vulnerabilities and address findings.

Common ISSO Skills and Qualifications

Employers often seek experience in information security, risk management, security controls, and regulatory or government frameworks. Familiarity with standards such as NIST guidance, authorization processes, incident response, and security assessment practices can be valuable. Some roles require a bachelor’s degree, relevant certifications, security clearance, or experience supporting federal systems; requirements differ by position.

ISSO Career Opportunities

ISSO professionals work across government contracting, defense, technology, healthcare, financial services, and other sectors with complex security needs. Depending on experience, they may advance into senior ISSO, information assurance, cybersecurity program management, or security leadership roles. Browse current listings to compare responsibilities, qualifications, work arrangements, and compensation.

Find ISSO Jobs on Ladders

Use Ladders to explore vetted professional opportunities, including Information Systems Security Officer jobs with salaries of $100,000 or more. Review each listing for its specific pay range, location, clearance requirements, and experience expectations, then apply to roles aligned with your background.

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1
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$149K - $240K *

Champion enterprise security solutions by partnering with Sales to address complex challenges. Lead technical discovery, solution design, and customer validation, ensuring alignment between technical...

Austin, TXRemote

3 days ago

  •   5 - 7 years exp.  •   Information Technology

$100K - $145K *

Support the engineering and maintenance of production system solutions, tackle complex technical architectures, and enhance automation through scripting for thousands of servers and virtual machines i...

West Virginia, USRemote

Reposted today

  •   Less than 5 years exp.  •   Information Technology

$170K - $212K *

Elevate AI security by designing robust frameworks to protect systems from threats. Collaborate with cross-functional teams to ensure compliance and ethical use, while implementing strategies that saf...

United StatesRemote

2 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$173K - $303K *

Unlock potential by leading the implementation of ServiceNow's Security and Risk solutions. Collaborate with customers and partners to drive business outcomes, provide architectural guidance, and ment...

San Diego, CARemote

2 days ago

  •   11 - 15 years exp.  •   Information Technology

$170K - $210K *

Empower Federal agencies by architecting and delivering AI-assisted software solutions. Responsible for client engagement, technology integration, and ensuring that production-ready solutions meet ope...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$80K - $95K *

Join a dynamic team ensuring EHR system security through effective management of access controls, security audits, and compliance with regulations. Collaborate with IT and clinical teams to protect pa...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Manufacturing & Automotive

$82K - $172K *

Champion eDiscovery project management by leading high-visibility initiatives for the DOJ. Collaborate with legal teams to ensure seamless project execution across all EDRM phases, delivering quality...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Information Technology

$104K - $166K *

Lead the charge in operational excellence for Private Cloud and AI Platform service delivery, ensuring optimal performance, SLA attainment, and continuous improvement across multiple data center envir...

Texas, USRemote

4 weeks ago

  •   11 - 15 years exp.  •   Aerospace & Defense

$98K - $120K *

Lead the design and implementation of automated workflows using SharePoint, Power Apps, and Power BI. Collaborate with stakeholders to enhance processes, provide training, and ensure seamless data int...

Virginia, USRemote

Today

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$95K - $115K *

Unlock your potential by leading innovative healthcare solutions that enhance patient care and operational efficiency. Collaborate with teams to design, implement, and optimize systems, ensuring effec...

Chicago, ILRemote

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$120K - $157K *

Reimagine cybersecurity by owning SaaS Security end-to-end while supporting Cyber Defense operations. Collaborate across teams to identify risks, enhance security posture, and ensure real-time inciden...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Shape the future of endpoint management by overseeing timely delivery of equipment, ensuring operational stability, and enhancing user satisfaction through effective personnel management and technical...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Real Estate & Construction

$73K - $132K *

Drive organizational change by analyzing processes, engaging stakeholders, and implementing effective strategies. Collaborate with teams to enhance operational efficiency and ensure successful adoptio...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Technical Services

$130K - $160K *

Join a team that's redefining compliance leadership by driving effective governance, risk management, and program strategy to enhance client success and operational efficiency in a hands-on environmen...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Enterprise Technology

$108K - $120K *

Champion customer success by leading technical account management efforts, optimizing customer engagement, and driving operational excellence in complex SaaS implementations across the public sector...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$114K - $252K *

Drive the development of advanced data pipelines in a cloud environment to centralize and govern critical data for national security operations. Lead a team in migrating legacy systems to modern solut...

United StatesRemote

4 weeks ago

  •   11 - 15 years exp.  •   Information Technology

$110K - $130K *

Join a team that's dedicated to securing web applications for federal clients. Collaborate in a cross-functional environment to implement security measures and threat detection, ensuring compliance wi...

Washington, DCRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

$110K - $130K *

Join a dynamic team focused on enhancing cybersecurity measures for web applications, ensuring compliance with industry standards while managing threats. Utilize your expertise to protect vital data a...

Washington, DCRemote

4 weeks ago

  •   8 - 10 years exp.  •   Staffing

$99K - $156K *

Engineer robust IT systems by managing identity, cloud infrastructure, and automation. Collaborate with cross-functional teams to enhance security and operational efficiency in a fast-paced, remote-fi...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$107K - $141K *

Unlock potential by leading internal project management and systems support for diverse information systems. Collaborate with teams to analyze data, enhance efficiency, and drive technology initiative...

Woodbridge, VARemote

1 week ago

  •   Less than 5 years exp.  •   Energy & Utilities

$110K - $130K *

Join a team that's committed to building, maintaining, and enhancing high-performance network infrastructure, ensuring optimal availability and security for our government client through innovative so...

Washington DC, USRemote

4 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$110K - $130K *

Transform your career by leading impactful HR communications that engage employees and enhance their understanding of benefits and career development. Collaborate with teams to create clear, actionabl...

Virginia, USRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$99K - $120K *

Partner with us to lead critical building automation systems' integration projects, providing technical expertise and support throughout the installation and commissioning phases. Your role will ensur...

El Paso, TXRemote

Reposted 4 weeks ago

  •   5 - 7 years exp.  •   Technical Services

$110K - $130K *

Drive your career with a leadership role overseeing satellite operations, ensuring mission success through effective scheduling, training, and ground system management. Lead a dedicated team in a dyna...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Aerospace & Defense

$77K - $122K *

Lead the charge in managing insurance and records for a global aerospace team. Collaborate with stakeholders to ensure compliance, optimize coverage, and enhance operational efficiency while overseein...

Anaheim, CARemote

1 week ago

  •   5 - 7 years exp.  •   Aerospace & Defense

Frequently Asked Questions (FAQ)

  • What is an Information Systems Security Officer (ISSO)?question toggle

    An ISSO is a cybersecurity professional who helps protect an organization’s information systems by coordinating security controls, assessing risks, maintaining documentation, and supporting compliance and authorization activities.

  • What qualifications are commonly required for ISSO jobs?question toggle

    Requirements vary, but employers commonly look for information security or IT experience, knowledge of security controls and risk management, and familiarity with relevant standards such as NIST guidance. Some positions may require a degree, professional certifications, or an active security clearance.

  • How much do Information Systems Security Officers earn?question toggle

    Compensation varies by employer, location, experience, clearance, and job scope. Ladders focuses on vetted professional jobs paying $100,000 or more; check each listing for its stated salary or compensation details.

  • Where do ISSOs work?question toggle

    ISSO roles are found in government and defense contracting, technology, healthcare, financial services, and other industries that manage sensitive or regulated information.

  • How can I find ISSO jobs paying $100,000 or more?question toggle

    Browse Information Systems Security Officer listings on Ladders and review each posting’s compensation, qualifications, location, and clearance requirements to find roles that fit your experience.