Discover vetted professional jobs paying $100,000 or more across North Carolina. From the Research Triangle to Charlotte and beyond, find career opportunities with employers seeking experienced talent in a range of industries. Browse current openings and explore roles that match your skills, experience, and career goals.
North Carolina offers a diverse economy, with opportunities in technology, financial services, healthcare, life sciences, manufacturing, and other professional fields. Job availability varies by location and employer, so search across the state to find positions that fit your background and preferred work arrangement.
Look for roles in Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, Winston-Salem, and other North Carolina communities. The Research Triangle is known for technology, life sciences, and research organizations, while Charlotte is a major center for banking and business. Opportunities are also available in cities and communities throughout the state.
Use Ladders to explore vetted opportunities with salaries of $100,000 or more. Review each listing for qualifications, responsibilities, location, and compensation details. Search by job title, industry, or city, and refine your search to focus on opportunities aligned with your professional experience.
Whether you are planning your next move or considering a new location, Ladders can help you discover high-paying professional jobs in North Carolina. Browse the latest listings and take the next step toward a role that supports your career ambitions.
Registered Nurse (RN) - Ortho-Urology
$79K - $118K *
Lead the charge in delivering exceptional patient care as a skilled RN, coordinating comprehensive nursing services in a dynamic medical-surgical unit. Collaborate with a dedicated team to ensure safe...
4 days ago
Director of the Bureau of Business Research
$100K - $120K *
Shape the future of applied research by leading the Bureau of Business Research. Drive strategic initiatives, foster partnerships, and deliver impactful insights to enhance economic vitality in Easter...
1 week ago
$145K - $175K *
Champion the design and implementation of scalable AI architectures, integrating data, models, and governance. Collaborate with cross-functional teams to drive enterprise AI solutions from concept to...
1 week ago
$80K - $95K *
Take ownership of strategic financial analyses and M&A activities to drive growth, evaluate investment opportunities, and support post-acquisition integration for organizational success and alignment...
Reposted 3 days ago
Project Manager, Clinical Portfolio
$80K - $145K *
Lead the charge in managing and delivering clinical portfolio initiatives with strong project management skills. Drive collaboration across teams, ensuring alignment to scope, timelines, and governanc...
Reposted 3 weeks ago
Project Manager, Clinical Portfolio
$80K - $145K *
Manage and deliver clinical portfolio initiatives, ensuring project alignment, accountability, and stakeholder coordination while operating independently through all phases of implementation...
Reposted 3 weeks ago
Senior Director, Head of Analytical Development
$250K - $275K *
Transform the future of drug development by leading Analytical Development for small molecules and oligonucleotides. Drive scientific strategy, build a high-performing team, and ensure regulatory read...
2 weeks ago
Enterprise Terafina Delivery Analyst
$80K - $95K *
Champion the Terafina delivery process by coordinating initiatives across digital account management, ensuring effective communication, prioritization, and stakeholder engagement to drive operational...
2 days ago
Technical Support Engineer (New England)
$72K - $112K *
Serve as a vital technical support resource in healthcare technology, ensuring system stability and customer satisfaction while managing service requests and collaborating with teams for quick resolut...
Reposted 3 weeks ago
$126K - $173K *
Lead the strategy and delivery of innovative IT solutions, bridging business needs with technical execution. Collaborate across teams to ensure products align with organizational goals and drive effic...
Reposted today
Advanced Practice Provider Pulmonary/Sleep
$90K - $110K *
Lead the charge in delivering exceptional patient care by providing comprehensive medical evaluations and treatments in a dynamic clinic environment, ensuring continuity of care and collaboration with...
2 weeks ago
Account Executive, Life Sciences & Medtech
$147K - $220K *
Champion transformative health solutions by managing key client relationships, driving sales, and collaborating across teams to enhance Verily's impact in Life Sciences. Leverage expertise to unlock n...
2 weeks ago
Senior Lease Admin Analyst - Remote EST
$75K - $90K *
Optimize lease administration processes by conducting detailed reconciliations and audits for large clients, ensuring compliance with lease terms while delivering accurate financial reporting and fost...
2 days ago
Sr Director GTM Subject Matter Expert
$190K - $220K *
Lead strategic initiatives in Go-To-Market (GTM) strategy for Patient Services, driving growth through collaboration with Business Development, Operations, and Marketing while influencing customer eng...
2 weeks ago
$100K - $120K *
Unlock potential by leading the Radiation Therapy department to achieve clinical and operational excellence, ensuring compliance with healthcare standards while fostering professional growth and quali...
1 week ago
Senior Manager, Clinical Conduct
$90K - $110K *
Empower cross-functional teams to drive the Future of Medicine initiatives, ensuring scalable processes and compliance while enhancing patient safety and experience through strategic planning and exec...
1 week ago
Senior Regional Sales Consultant
$95K - $115K *
Transform healthcare engagement by building relationships with HCPs through digital interactions and telephone conversations, promoting products, and achieving sales goals while ensuring compliance wi...
1 week ago
Strategic Account Executive; U500 (Hybrid; Carolinas)
$100K - $120K *
Build trusted client relationships and drive strategic growth by leveraging market insights and financial expertise to enhance client experiences and outcomes. Collaborate across teams to deliver inte...
1 week ago
Manager, People Analytics & Data Science
$128K - $252K *
Drive the evolution of people analytics by building data pipelines, dashboards, and insights that empower leaders with decision-ready information. Collaborate across teams to enhance data usability an...
1 week ago
$110K - $130K *
Engage in the design and management of enterprise endpoint technologies, ensuring security and efficiency across over 1,000 devices. Collaborate with cross-functional teams to enhance endpoint perform...
2 weeks ago
$100K *
Drive data-driven decision-making by developing automated reporting solutions. Collaborate with cross-functional teams to enhance enterprise reporting, ensuring accuracy and efficiency while translati...
2 weeks ago
Director, Treasury & Strategic Forecasting
$135K - $160K *
Transform global treasury operations by leading cash forecasting, debt management, and strategic financial planning. Drive process enhancements and collaborate with senior leadership to ensure financi...
2 weeks ago
Manager Quality - Unified Quality Medical Center SES
$95K - $115K *
Lead quality assurance initiatives to enhance clinical outcomes and regulatory compliance. Collaborate with cross-functional teams to standardize processes, oversee data integrity, and drive performan...
1 week ago
Physical Therapist I - Outpatient
$74K - $110K *
Join a team that's dedicated to optimizing patient care through comprehensive evaluations and tailored rehabilitation plans. Collaborate with healthcare professionals to enhance patient outcomes in a...
5 days ago
$125K - $150K *
Drive solutions for employer benefit ecosystems by leading pre-sales efforts, analyzing client needs, and designing tailored implementations for optimal savings and member engagement, collaborating cl...
3 weeks ago
What types of $100K+ jobs can I find in North Carolina?
North Carolina listings may include professional and leadership roles in technology, financial services, healthcare, life sciences, manufacturing, and other industries. Available jobs and compensation depend on the employer, location, and qualifications.
Which North Carolina cities have professional job opportunities?
You can search for roles in cities including Charlotte, Raleigh, Durham, Chapel Hill, Greensboro, and Winston-Salem, as well as other communities across the state.
Are the jobs on this page vetted?
Ladders hosts vetted professional job opportunities that pay $100,000 or more. Check individual listings for details about the employer, requirements, location, and compensation.
How can I find a specific type of job in North Carolina?
Search by job title, industry, or city, then use available filters to narrow results by factors such as experience level or work arrangement.
Do all North Carolina jobs on Ladders pay at least $100,000?
Ladders focuses on professional jobs paying $100,000 or more. Review each listing to confirm its compensation information and details.