Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$122K - $179K *

Advance your career by leading enterprise analytics and data governance initiatives. Collaborate with executive leadership to create analytics solutions that drive strategic decision-making and enhanc...

United StatesRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$129K - $162K *

Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...

United StatesRemote

Reposted 1 week ago

  •   5 - 7 years exp.  •   Healthcare

$87K - $157K *

Lead the charge in transforming healthcare data solutions by leveraging advanced SQL, Snowflake, and SAS expertise. Collaborate with cross-functional teams to enhance business processes and ensure com...

RemoteRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$89K - $148K *

Lead the charge in enhancing financial operations by delivering advanced analysis, ensuring compliance, and supporting internal controls for federal financial systems, contributing to a high-performin...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Business Services

$80K - $95K *

Transform your career by enhancing data security and integrity. Collaborate with cross-functional teams to implement robust security measures, conduct audits, and mitigate risks while staying ahead of...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $150K *

Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Business Services

$95K - $115K *

Unlock potential by leveraging data science to drive informed decision-making through advanced analytics, modeling, and collaboration in a dynamic research environment...

United StatesRemote

6 days ago

  •   Less than 5 years exp.  •   Aerospace & Defense

$80K - $95K *

Join a team that's dedicated to enhancing application services in cloud environments. You'll install and upgrade applications while collaborating with experts to ensure optimal performance and support...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$127K - $223K *

Analyze channel performance and drive data-driven decisions by building models, validating vendor claims, and proactively answering business questions to enhance offline and direct mail strategies...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Finance & Insurance

$80K - $95K *

Advance operational excellence by leading continuous improvement initiatives, optimizing processes, and engaging stakeholders across departments to drive measurable results and enhance efficiency in a...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$80K - $95K *

Drive HRIS excellence by managing system optimization, data integrity, and strategic integrations. Collaborate across departments to enhance workforce technology and advocate for best practices in a d...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$170K - $190K *

Engineer data strategies and methodologies for emerging sectors, transforming complex datasets into actionable insights. Lead a team while collaborating cross-functionally to enhance data accuracy and...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Drive transformation by collaborating with stakeholders to analyze and enhance business processes, ensuring effective technology adoption and operational improvements within a dynamic environment...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$83K - $129K *

Lead the charge in advanced compliance activities, ensuring administrative solutions align with laws and regulations. Utilize AI tools to enhance efficiency, guide teams, and deliver scalable complian...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $300K *

Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Finance & Insurance

$68K - $143K *

Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Information Technology

$68K - $113K *

Champion the enhancement of data security services by managing complex projects and day-to-day operations. Utilize technical expertise to safeguard sensitive information and ensure compliance with ind...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Business Services

$150K - $180K *

Elevate your career by guiding the architecture of cutting-edge enterprise systems, providing strategic technical direction and mentoring teams on best practices across .NET, Azure, and SQL Server to...

Reposted 1 week ago

  •   8 - 10 years exp.  •   Staffing

$100K - $120K *

Manage the operational backbone of multiple HCI portfolios by coordinating and executing initiatives, engaging with diverse stakeholders, and overseeing project timelines, budgets, and deliverables fo...

RemoteRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$120K - $145K *

Join a team that's building and scaling a data and analytics platform to enhance clinical AI performance. Collaborate with cross-functional teams to create actionable insights and drive improvements i...

United StatesRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Transform patient care by delivering expert anesthesia services. Collaborate with anesthesia teams to ensure safety and quality, while excelling in clinical responsibilities and patient monitoring thr...

Reposted today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$90K - $110K *

Join our Skilled Nursing Facility team to deliver quality patient care, perform therapeutic procedures, and support patient education. This role offers a collaborative environment for both new graduat...

3 weeks ago

  •   Less than 5 years exp.  •   Staffing

$80K - $95K *

Transform compensation strategies by analyzing job evaluations, benchmarking, and implementing efficient processes. Collaborate with management to ensure competitive pay practices and support business...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$121K - $224K *

Manage and coordinate enterprise-wide incident response efforts, ensuring compliance and effective communication across departments while integrating threat monitoring services and enhancing processes...

Missouri, USRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$82K - $137K *

Transform business insights into actionable data solutions by collaborating with stakeholders, analyzing data quality, and ensuring effective integration of analytical products to drive operational ef...

United StatesRemote

Reposted 4 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.