Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Enterprise Analytics Consultant - Remote
$122K - $179K *
Advance your career by leading enterprise analytics and data governance initiatives. Collaborate with executive leadership to create analytics solutions that drive strategic decision-making and enhanc...
Reposted 2 weeks ago
Director, Cost of Care Solutions
$129K - $162K *
Unlock potential by leading enterprise-wide Cost of Care solutions. Drive scalability, optimize deployment, and enhance operational effectiveness across diverse markets, collaborating with stakeholder...
Reposted 1 week ago
Senior Business Technical Analyst
$87K - $157K *
Lead the charge in transforming healthcare data solutions by leveraging advanced SQL, Snowflake, and SAS expertise. Collaborate with cross-functional teams to enhance business processes and ensure com...
Yesterday
$89K - $148K *
Lead the charge in enhancing financial operations by delivering advanced analysis, ensuring compliance, and supporting internal controls for federal financial systems, contributing to a high-performin...
2 days ago
$80K - $95K *
Transform your career by enhancing data security and integrity. Collaborate with cross-functional teams to implement robust security measures, conduct audits, and mitigate risks while staying ahead of...
3 weeks ago
Healthcare Tech Manager - Epic Professional Billing
$130K - $150K *
Shape impactful healthcare solutions by leveraging your Epic Professional Billing expertise. Collaborate with diverse teams to optimize systems, enhance workflows, and drive meaningful results for cli...
3 weeks ago
$95K - $115K *
Unlock potential by leveraging data science to drive informed decision-making through advanced analytics, modeling, and collaboration in a dynamic research environment...
6 days ago
$80K - $95K *
Join a team that's dedicated to enhancing application services in cloud environments. You'll install and upgrade applications while collaborating with experts to ensure optimal performance and support...
3 weeks ago
$127K - $223K *
Analyze channel performance and drive data-driven decisions by building models, validating vendor claims, and proactively answering business questions to enhance offline and direct mail strategies...
Reposted today
Continuous Improvement Analyst III
$80K - $95K *
Advance operational excellence by leading continuous improvement initiatives, optimizing processes, and engaging stakeholders across departments to drive measurable results and enhance efficiency in a...
5 days ago
$80K - $95K *
Drive HRIS excellence by managing system optimization, data integrity, and strategic integrations. Collaborate across departments to enhance workforce technology and advocate for best practices in a d...
4 weeks ago
$170K - $190K *
Engineer data strategies and methodologies for emerging sectors, transforming complex datasets into actionable insights. Lead a team while collaborating cross-functionally to enhance data accuracy and...
3 weeks ago
$90K - $110K *
Drive transformation by collaborating with stakeholders to analyze and enhance business processes, ensuring effective technology adoption and operational improvements within a dynamic environment...
2 weeks ago
$83K - $129K *
Lead the charge in advanced compliance activities, ensuring administrative solutions align with laws and regulations. Utilize AI tools to enhance efficiency, guide teams, and deliver scalable complian...
4 weeks ago
$100K - $300K *
Lead complex analytical initiatives by developing data solutions and dashboards that drive business insights. Collaborate with stakeholders to translate requirements into scalable analytical framework...
1 week ago
$68K - $143K *
Support audit and compliance efforts for DoD financial systems, ensuring adherence to GAGAS and federal standards. Collaborate with stakeholders to enhance internal controls and audit readiness, drivi...
6 days ago
$68K - $113K *
Champion the enhancement of data security services by managing complex projects and day-to-day operations. Utilize technical expertise to safeguard sensitive information and ensure compliance with ind...
Reposted today
Enterprise Principal Architect
$150K - $180K *
Elevate your career by guiding the architecture of cutting-edge enterprise systems, providing strategic technical direction and mentoring teams on best practices across .NET, Azure, and SQL Server to...
Reposted 1 week ago
Healthcare Improvement Project Manager
$100K - $120K *
Manage the operational backbone of multiple HCI portfolios by coordinating and executing initiatives, engaging with diverse stakeholders, and overseeing project timelines, budgets, and deliverables fo...
Reposted 3 weeks ago
Software Engineer, Data & Analytics Platform
$120K - $145K *
Join a team that's building and scaling a data and analytics platform to enhance clinical AI performance. Collaborate with cross-functional teams to create actionable insights and drive improvements i...
6 days ago
$160K - $200K *
Transform patient care by delivering expert anesthesia services. Collaborate with anesthesia teams to ensure safety and quality, while excelling in clinical responsibilities and patient monitoring thr...
Reposted today
$90K - $110K *
Join our Skilled Nursing Facility team to deliver quality patient care, perform therapeutic procedures, and support patient education. This role offers a collaborative environment for both new graduat...
3 weeks ago
$80K - $95K *
Transform compensation strategies by analyzing job evaluations, benchmarking, and implementing efficient processes. Collaborate with management to ensure competitive pay practices and support business...
2 weeks ago
Principal Incident Response Analyst
$121K - $224K *
Manage and coordinate enterprise-wide incident response efforts, ensuring compliance and effective communication across departments while integrating threat monitoring services and enhancing processes...
5 days ago
$82K - $137K *
Transform business insights into actionable data solutions by collaborating with stakeholders, analyzing data quality, and ensuring effective integration of analytical products to drive operational ef...
Reposted 4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.