Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
NP or PA for Pulm/Sleep Medicine (Springfield and Branson)
$90K - $110K *
Deliver advanced nursing care by collaborating with physicians to enhance patient outcomes, manage cases, and evaluate performance. Engage in physical examinations, diagnostic testing, and treatment p...
2 weeks ago
$71K - $106K *
Lead the charge in delivering exceptional patient care as a Charge Nurse in a high-acuity Emergency Services department, ensuring safety, quality, and effective communication among healthcare teams wh...
Reposted 1 week ago
Product Expansion Lead at AIOS - Remote, $200k-$400k/yr + 0.15%-0.50% equity
$200K - $400K *
Champion product expansion by launching and scaling non-GLP-1 offerings. Drive growth strategies, analyze market opportunities, and collaborate across teams to ensure successful product launches and r...
Yesterday
$80K - $95K *
Lead advanced troubleshooting and repair of medical equipment, ensuring customer satisfaction through service excellence. Collaborate with teams, mentor junior engineers, and drive initiatives to enha...
3 weeks ago
Hemostasis Sales Specialist - Northern California Region
$99K - $136K *
Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...
3 weeks ago
Client Portfolio Manager - Medical Device Services
$88K - $105K *
Join a team that's dedicated to managing and growing medical device testing portfolios. This role bridges Business Development and Operations, ensuring client objectives are met through high-quality p...
6 days ago
$98K - $163K *
Join a team that's dedicated to enhancing fraud risk assessments for digital services. You'll evaluate risks, identify fraud controls, and support ongoing assessments, ensuring timely delivery and eff...
Today
Sr. Director, Integrated Evidence Generation Lead
$175K - $210K *
Lead pioneering evidence generation initiatives to inform oncology product strategies and lifecycle management through cross-functional collaboration and data-driven decision-making...
Reposted 1 week ago
Senior Oncology Account Specialist Hematology Detroit South, MI
$108K - $250K *
Elevate your career by driving oncology sales, promoting top-tier products, and enhancing healthcare provider relationships to improve patient outcomes and access within key accounts. Be a pivotal for...
Reposted today
$124K *
Advance patient care by providing comprehensive nursing services in a dynamic behavioral health setting. Collaborate with healthcare teams to assess, plan, and implement effective treatment strategies...
1 week ago
Staff Attorney - St. Louis Metro Region
$74K - $90K *
Join a team that's dedicated to advancing child welfare through active litigation. As a Staff Attorney, you'll provide legal counsel, manage diverse cases, and advocate for families in juvenile court...
6 days ago
$164K - $305K *
Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...
1 week ago
$120K - $140K *
Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...
Reposted today
Manager of Utilization Management
$108K - $147K *
Lead a dynamic team in enhancing member-centered care through effective utilization management. Drive quality improvement, ensure compliance, and foster strategic partnerships to optimize healthcare d...
5 days ago
$90K *
Transform the efficiency of distribution operations by optimizing processes, implementing continuous improvement initiatives, and leveraging advanced technologies to enhance productivity and service l...
Reposted today
Remote PMO Senior Quality Analyst (VA ESOM)
$100K - $115K *
Optimize quality analytics and reporting for program deliverables, ensuring compliance with standards and client expectations. Collaborate with senior leaders to provide actionable insights and drive...
1 week ago
$175K - $250K *
Unlock potential by leading pricing strategy and actuarial modeling for Commercial lines, ensuring regulatory compliance and operational excellence while collaborating across teams to drive profitable...
2 weeks ago
$105K - $120K *
Drive impactful research initiatives by leading complex projects, mentoring teams, and securing new business opportunities. Collaborate with diverse stakeholders to deliver high-quality evaluations an...
1 week ago
$150K - $180K *
Lead and grow a high-performing Guidewire practice, driving strategy and delivery excellence in digital transformations for insurance clients, while fostering client relationships and mentoring teams...
Reposted 3 days ago
$104K - $156K *
Join us to architect innovative financial systems, leading greenfield projects that enhance data management and analytics. Collaborate across teams to implement your vision and drive impactful solutio...
5 days ago
Associate General Counsel, Legal (US)
$200K - $398K *
Drive impactful legal strategies in a global clinical research environment, guiding senior leadership on complex regulatory and compliance matters while fostering innovation and risk management across...
4 weeks ago
Sr. Engineer, AI Cyber Security
$140K - $187K *
Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...
3 weeks ago
$79K - $127K *
Accelerate progress at our organization by leveraging your expertise in Mainframe technical solutions. Collaborate with cross-functional teams to design, develop, and maintain robust systems, ensuring...
Today
$95K - $115K *
Pioneer data-driven decision-making by analyzing operational metrics and financial performance. Collaborate with leadership to enhance efficiency and drive continuous improvement in a fast-paced manuf...
1 week ago
$114K - $210K *
Champion the development of regulatory documents for global submissions, managing timelines and cross-functional collaboration to ensure quality and compliance with industry standards while mentoring...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.