Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$90K - $110K *

Deliver advanced nursing care by collaborating with physicians to enhance patient outcomes, manage cases, and evaluate performance. Engage in physical examinations, diagnostic testing, and treatment p...

2 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$71K - $106K *

Lead the charge in delivering exceptional patient care as a Charge Nurse in a high-acuity Emergency Services department, ensuring safety, quality, and effective communication among healthcare teams wh...

Reposted 1 week ago

  •   Less than 5 years exp.  •   Healthcare

$200K - $400K *

Champion product expansion by launching and scaling non-GLP-1 offerings. Drive growth strategies, analyze market opportunities, and collaborate across teams to ensure successful product launches and r...

United StatesRemote

Yesterday

  •   Less than 5 years exp.  •   Healthcare

$80K - $95K *

Lead advanced troubleshooting and repair of medical equipment, ensuring customer satisfaction through service excellence. Collaborate with teams, mentor junior engineers, and drive initiatives to enha...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Business Services

$99K - $136K *

Elevate your career by driving strategic growth in Hemostasis solutions. As a key player, you'll lead complex sales cycles, cultivate executive relationships, and deliver measurable value across healt...

RemoteRemote

3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$88K - $105K *

Join a team that's dedicated to managing and growing medical device testing portfolios. This role bridges Business Development and Operations, ensuring client objectives are met through high-quality p...

6 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$98K - $163K *

Join a team that's dedicated to enhancing fraud risk assessments for digital services. You'll evaluate risks, identify fraud controls, and support ongoing assessments, ensuring timely delivery and eff...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Business Services

$175K - $210K *

Lead pioneering evidence generation initiatives to inform oncology product strategies and lifecycle management through cross-functional collaboration and data-driven decision-making...

RemoteRemote

Reposted 1 week ago

  •   11 - 15 years exp.  •   Pharmaceuticals & Biotech

$108K - $250K *

Elevate your career by driving oncology sales, promoting top-tier products, and enhancing healthcare provider relationships to improve patient outcomes and access within key accounts. Be a pivotal for...

RemoteRemote

Reposted today

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$124K *

Advance patient care by providing comprehensive nursing services in a dynamic behavioral health setting. Collaborate with healthcare teams to assess, plan, and implement effective treatment strategies...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$74K - $90K *

Join a team that's dedicated to advancing child welfare through active litigation. As a Staff Attorney, you'll provide legal counsel, manage diverse cases, and advocate for families in juvenile court...

6 days ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$164K - $305K *

Lead the charge in developing strategic relationships with C-suite executives to drive growth, retention, and value realization across complex health systems, ensuring integrated solutions and measura...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$120K - $140K *

Lead the charge in delivering innovative healthcare solutions by engaging with clients, understanding their needs, and providing technical guidance throughout the sales process to drive successful out...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$108K - $147K *

Lead a dynamic team in enhancing member-centered care through effective utilization management. Drive quality improvement, ensure compliance, and foster strategic partnerships to optimize healthcare d...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$90K *

Transform the efficiency of distribution operations by optimizing processes, implementing continuous improvement initiatives, and leveraging advanced technologies to enhance productivity and service l...

Reposted today

  •   Less than 5 years exp.  •   Finance & Insurance

$100K - $115K *

Optimize quality analytics and reporting for program deliverables, ensuring compliance with standards and client expectations. Collaborate with senior leaders to provide actionable insights and drive...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Information Technology

$175K - $250K *

Unlock potential by leading pricing strategy and actuarial modeling for Commercial lines, ensuring regulatory compliance and operational excellence while collaborating across teams to drive profitable...

United StatesRemote

2 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$105K - $120K *

Drive impactful research initiatives by leading complex projects, mentoring teams, and securing new business opportunities. Collaborate with diverse stakeholders to deliver high-quality evaluations an...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$150K - $180K *

Lead and grow a high-performing Guidewire practice, driving strategy and delivery excellence in digital transformations for insurance clients, while fostering client relationships and mentoring teams...

United StatesRemote

Reposted 3 days ago

  •   11 - 15 years exp.  •   Information Technology

$104K - $156K *

Join us to architect innovative financial systems, leading greenfield projects that enhance data management and analytics. Collaborate across teams to implement your vision and drive impactful solutio...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$200K - $398K *

Drive impactful legal strategies in a global clinical research environment, guiding senior leadership on complex regulatory and compliance matters while fostering innovation and risk management across...

RemoteRemote

4 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $187K *

Innovate the future of AI security by designing and implementing robust defenses against adversarial threats, ensuring the integrity of AI systems while fostering innovation and collaboration across c...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$79K - $127K *

Accelerate progress at our organization by leveraging your expertise in Mainframe technical solutions. Collaborate with cross-functional teams to design, develop, and maintain robust systems, ensuring...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$95K - $115K *

Pioneer data-driven decision-making by analyzing operational metrics and financial performance. Collaborate with leadership to enhance efficiency and drive continuous improvement in a fast-paced manuf...

1 week ago

  •   5 - 7 years exp.  •   Manufacturing & Automotive

$114K - $210K *

Champion the development of regulatory documents for global submissions, managing timelines and cross-functional collaboration to ensure quality and compliance with industry standards while mentoring...

RemoteRemote

6 days ago

  •   5 - 7 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.