Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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Healthcare Analyst Jobs in Missouri

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$63K - $104K *

Join a team that's dedicated to providing exceptional clinical nutrition care. You'll conduct assessments, develop individualized interventions, and collaborate with healthcare professionals to enhanc...

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$165K - $175K *

Empower progress at the forefront of data product management, leading the development of innovative solutions. Drive product success through strategic oversight, client engagement, and cross-functiona...

United StatesRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Transform client relationships by managing subservicing deliverables, ensuring compliance, and enhancing reporting processes. Collaborate with vendors and internal teams to support client needs and dr...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Real Estate & Construction

$80K - $95K *

Elevate patient care by leading nursing teams, developing policies, and ensuring compliance. Drive operational efficiency and foster a supportive environment while collaborating with interdisciplinary...

3 weeks ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$114K - $187K *

Optimize clinical data management processes by leading teams and ensuring compliance with standards. Collaborate with stakeholders to enhance data quality and streamline operations across multiple com...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$95K - $115K *

Join a team that's dedicated to enhancing ERP solutions for colleges and universities. As a consultant, you'll collaborate on Ellucian Banner implementations, ensuring client needs are met within scop...

United StatesRemote

Reposted today

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$106K - $141K *

Join a team that's building an AI-ready data foundation for marketing and GTM. You'll design, govern, and analyze data models, ensuring reliable insights for strategic decision-making across the organ...

United StatesRemote

2 weeks ago

  •   5 - 7 years exp.  •   Information Technology

$105K - $202K *

Engineer robust data platforms by designing scalable pipelines and APIs that support AI-driven healthcare applications, ensuring high performance, security, and operational excellence in a collaborati...

United StatesRemote

Reposted yesterday

  •   5 - 7 years exp.  •   Healthcare

$185K - $215K *

Take ownership of analytical development initiatives, ensuring compliance, accuracy, and high-quality documentation for multiple projects. Collaborate closely with internal teams and external partners...

United StatesRemote

Reposted today

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$110K - $130K *

Lead the charge in developing referral growth and market strategies across multiple states. Drive sustainable growth by optimizing processes, leveraging CRM systems, and building high-performing teams...

United StatesRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

$140K - $175K *

Empower Apollo's frontier partnerships by deepening collaborations with AI-native platforms and foundation model companies. Analyze the evolving landscape and drive monetization strategies while build...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Enterprise Technology

$100K - $120K *

Transform oral healthcare by providing comprehensive dental services, diagnosing conditions, and developing treatment plans. Collaborate with a dedicated team to enhance patient outcomes and serve und...

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$130K - $140K *

Shape the future of IT operations by bridging infrastructure and development teams. Utilize your expertise in ServiceNow ITOM to analyze requirements, streamline processes, and enhance operational eff...

United StatesRemote

4 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$110K - $130K *

Transform endpoint management by designing and deploying solutions across a vast device estate. Collaborate with cross-functional teams to ensure security, compliance, and reliability while leveraging...

United StatesRemote

4 weeks ago

  •   8 - 10 years exp.  •   Pharmaceuticals & Biotech

$118K - $196K *

Transform employee equity and shareholder services by leading stock plan operations, ensuring compliance and accuracy while collaborating with cross-functional teams to enhance processes and support s...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $110K *

Elevate the impact of early childhood development by managing and expanding the HELP product suite. Drive customer relationships, account growth, and new business development while supporting practiti...

United StatesRemote

1 week ago

  •   5 - 7 years exp.  •   Education, Government & Non-Profit

$209K - $275K *

Elevate your career by leading and developing a high-performing Solutions Engineering team. Drive strategic alignment across functions, foster technical excellence, and implement innovative practices...

RemoteRemote

Reposted 2 weeks ago

  •   5 - 7 years exp.  •   Telecommunications & Hardware

$100K - $110K *

Drive valuable insights by enhancing Anaplan models and dashboards, collaborating with teams to implement solutions and improve functionality, while supporting users throughout the development lifecyc...

United StatesRemote

Reposted 1 week ago

  •   Less than 5 years exp.  •   Real Estate & Construction

$100K - $120K *

Unlock potential by mentoring new providers through virtual education, ensuring a seamless onboarding experience. Leverage your clinical expertise to foster growth in both primary care and behavioral...

United StatesRemote

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$95K - $125K *

Unlock potential by joining a collaborative team focused on delivering comprehensive primary care. Engage with patients in an outpatient setting, emphasizing preventive care and wellness while working...

6 days ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$155K - $210K *

Shape the future of regulatory policy by leading initiatives that influence key decisions and drive alignment across teams. Collaborate with stakeholders to advocate for impactful policies that suppor...

United StatesRemote

5 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$191K - $305K *

Champion innovative healthcare solutions by leveraging clinical expertise to enhance value-based strategies, drive operational excellence, and foster strategic partnerships for improved member care an...

RemoteRemote

4 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$160K - $200K *

Support a dynamic team providing exceptional anesthesia care in a collaborative outpatient GI setting. Enjoy a predictable schedule with no call responsibilities, leveraging your skills in a modern, a...

Reposted today

  •   Less than 5 years exp.  •   Healthcare

$65K - $116K *

Engage with clients to ensure seamless delivery of Insurance Discovery services, managing relationships and expectations while coordinating with internal teams for successful implementation and ongoin...

United StatesRemote

Yesterday

  •   5 - 7 years exp.  •   Healthcare

$165K - $264K *

Pioneer cross-functional collaboration to manage IS projects, ensuring successful implementation and support of applications, upgrades, and integrations while overseeing budgets and resources across S...

RemoteRemote

1 week ago

  •   8 - 10 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.