Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Director of Psychiatric Clinical Operations
$175K - $210K *
Champion operational excellence in psychiatric care by leading a dynamic team focused on quality, compliance, and innovation. Drive improvements in provider operations and enhance mental healthcare de...
4 days ago
$91K - $118K *
Lead the development and enhancement of critical software applications, ensuring performance and stability while collaborating with cross-functional teams to deliver market-driven solutions and suppor...
2 days ago
Client Success Manager - Law Firms
$85K - $95K *
Lead the charge in client engagement and lifecycle management, driving retention and organic growth within legal accounts. Build relationships, identify cross-sell opportunities, and ensure high clien...
2 weeks ago
Healthcare Marketing Strategy Manager
$163K - $322K *
Transform health care marketing through strategy consulting, leading teams to enhance client engagements and optimize performance across the CMO's agenda, driving measurable results in a dynamic envir...
Reposted today
Analyst I, Falcon Complete GovCloud (Hybrid, St. Louis)
$85K - $120K *
Drive global security initiatives by leveraging hands-on technical skills in incident response and threat analysis. Collaborate with like-minded professionals to protect organizations from advanced cy...
Reposted 2 weeks ago
$272K - $408K *
Unlock enterprise growth by leading innovation strategies, managing a diverse portfolio, and fostering partnerships to create scalable business opportunities that drive long-term value and address eme...
2 weeks ago
Regulatory Affairs Consultant - Regulatory Generalist
$100K - $120K *
Take ownership of regulatory support for pharmaceutical programs, managing IND and NDA submissions, health authority interactions, and lifecycle maintenance. Collaborate with cross-functional teams to...
3 weeks ago
Senior Manager, Health Plan Operations
$110K - $150K *
Champion operational excellence by leading Payment Integrity initiatives, ensuring accurate claims processing, optimizing workflows, and driving cross-functional collaboration to enhance performance a...
Today
$80K - $95K *
Champion integrated psychological services for transplant patients, conducting evaluations and delivering therapy across inpatient and outpatient settings. Collaborate with multidisciplinary teams to...
5 days ago
ADON/Nurse 8:30a-5p with On-Call (Full-Time)
$86K - $87K *
Transform the care experience by leading a dedicated team, managing personalized care plans, and ensuring compliance with regulations while fostering a supportive community culture for residents and f...
3 weeks ago
ADON/Nurse 8:30a-5p with On-Call (Full-Time)
$86K - $87K *
Advance your career by coordinating exceptional care for residents, fostering a supportive community culture, and ensuring compliance with care standards while collaborating with families and staff to...
3 weeks ago
Lead Solutions Architect - HR Technology & AI
$106K - $284K *
Transform your career by leading the design and development of innovative HR Technology solutions. Drive architectural vision and collaborate with stakeholders to ensure alignment with business object...
Yesterday
$100K - $160K *
Lead the charge in driving security business growth by identifying opportunities, engaging prospects, and leveraging expertise to close deals. Collaborate with sales teams to enhance customer adoption...
Today
$88K - $154K *
Lead the charge in enhancing safety and quality standards; administer the Risk Program and conduct audits, assessments, and training. Collaborate with various stakeholders to ensure compliance and imp...
Reposted 4 weeks ago
Associate Director, Enterprise Information Architecture
$143K - $193K *
Accelerate progress at the forefront of data-driven transformation in life sciences. Collaborate with leadership to shape and execute enterprise data architecture initiatives, ensuring scalable, trust...
3 weeks ago
Clinical Expert Advisor - Remote, US
$162K - $224K *
Transform healthcare operations by leveraging your expertise to drive efficiency and improve outcomes. Engage with clients to analyze needs, manage projects, and lead teams in delivering sustainable p...
6 days ago
$80K - $92K *
Drive the resolution of technical support escalations as a key Tier 2 expert, leveraging your skills to troubleshoot issues, foster collaboration within teams, and enhance workflows in a dynamic envir...
Reposted 5 days ago
Director, Field Effectiveness, Obesity and Related Conditions
$193K - $262K *
Lead and optimize field effectiveness initiatives, driving sales performance through insights and operational excellence. Manage a high-performing team while collaborating cross-functionally to enhanc...
5 days ago
Information Systems Security Officer
$143K - $175K *
Transform the landscape of information security by leading comprehensive RMF assessments and mentoring junior staff. Drive compliance and innovation in cybersecurity for emerging technologies while ma...
6 days ago
National Account Executive, Employee Benefits
$121K - $152K *
Shape the future of employee benefits by delivering strategic account management and innovative solutions that drive client growth and retention while fostering impactful partnerships with national ac...
Reposted yesterday
Managing Attorney Central Region
$95K *
Champion impactful legal solutions by leading a team of attorneys in diverse litigation, ensuring effective case management and collaboration with various stakeholders to uphold justice and public ser...
2 weeks ago
$110K - $130K *
Discover a pivotal role as a Pharmacy Actuary, bridging pharmacy strategy and actuarial insights. Collaborate with cross-functional teams to enhance financial projections and support strategic pricing...
5 days ago
$80K - $95K *
Support payroll and benefits operations for a remote workforce, ensuring compliance and accuracy in processing. Collaborate with HR and Finance to enhance employee experience and streamline processes...
Today
New Business Sales Executive - Western Territory
$100K - $120K *
Drive revenue growth by cultivating relationships and managing the full-cycle sales process in the healthcare technology sector. Utilize AI-driven solutions to enhance client performance and deliver v...
1 week ago
Registered Nurse Manager (Cath Lab/Interventional Radiology)
$85K - $100K *
Transform healthcare delivery by leading a dedicated team in Cath Lab/IR operations. Drive excellence in nursing practice, foster collaboration, and enhance patient care through effective leadership a...
5 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.