Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Sr. Revenue Accountant/Analyst
$80K - $95K *
Drive the month-end close process by ensuring accurate revenue recognition and analysis. Collaborate across departments to produce insightful reports and support financial decision-making while adheri...
2 weeks ago
$115K - $145K *
Transform business operations by developing and deploying AI solutions that enhance product capabilities and customer experiences. Collaborate with cross-functional teams to integrate machine learning...
Today
Consultant Relations Senior Manager
$170K - $200K *
Elevate our Enterprise business by building impactful relationships with brokers and consultants. Drive engagement strategies, generate new business opportunities, and enhance BetterHelp's presence in...
3 weeks ago
Workday HCM Optimization Manager
$118K - $196K *
Deliver optimized Workday solutions through assessments, deployments, and client engagements. Lead design sessions, streamline processes, and enhance customer satisfaction in a collaborative and innov...
Reposted 2 weeks ago
Director, Diagnosis-Related Group Validation (DRGV)
$125K - $150K *
Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...
3 weeks ago
Senior Java Developer - Healthcare / PBM Platform
$96K - $125K *
Join a team that's dedicated to building high-performance Java applications for healthcare. Collaborate in Agile environments to design scalable microservices and troubleshoot complex issues, driving...
1 month ago
Revenue Cycle Managed Services - Billing Manager (Hospital System)
$100K - $120K *
Transform billing operations by leading a team to optimize healthcare revenue cycle processes, ensuring timely and accurate claims submission while driving performance improvements and fostering stron...
2 weeks ago
Product Manager - Vendor Oversight
$113K - $197K *
Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...
2 weeks ago
$85K - $100K *
Join a team that's dedicated to delivering high-quality, patient-centered care in Interventional Radiology. Collaborate with healthcare professionals to evaluate patients, perform procedures, and supp...
4 days ago
$90K - $110K *
Join a dedicated team of professionals providing comprehensive advanced practice nursing for acute and chronic pain management. Collaborate in a multidisciplinary environment to deliver high-quality...
Reposted 3 weeks ago
Associate Director, Compliance
$110K - $130K *
Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...
2 weeks ago
$170K - $210K *
Join a dynamic team to develop transformative brand strategies that inspire clients and drive impactful campaigns. Collaborate across functions to deliver insights and solutions that elevate brand per...
4 days ago
LEAD COORDINATOR SOCIAL WORK-OHIORISE
$83K - $107K *
Join a dynamic team to enhance patient care through interdisciplinary collaboration, psychosocial assessments, and resource development. Lead initiatives that empower families and improve health outco...
Today
AI Platform Analyst (St. Louis)
$71K - $106K *
Join a dynamic team as you support AI platform operations, ensuring quality and performance across custom applications. Collaborate with stakeholders to enhance user experience and drive continuous im...
Reposted 1 week ago
Forward Deployed Engineer - FDE - Healthcare
$110K - $130K *
Join a team that's transforming healthcare by connecting groundbreaking products with clients. You'll lead onboarding, design impactful use cases, and advocate for customer success, ensuring seamless...
Reposted 5 days ago
Manager, Financial Planning and Analysis
$109K - $175K *
Lead the charge in financial planning and analysis, driving accurate forecasts, budgets, and financial insights to support business objectives and enhance decision-making across departments...
Yesterday
Advanced Practice Provider - Pre-Admission Testing Center
$95K - $115K *
Help us redefine patient care as an advanced practice nurse, overseeing assessments, diagnoses, and collaborative treatment plans. Join a team that values your skills and fosters professional growth i...
Reposted 2 weeks ago
BPaaS GTM Solutions Architect (Provider, Hospitals, Clinic)
$182K - $337K *
Create innovative AI-native business process solutions for healthcare providers. Collaborate with stakeholders to design efficient architectures that enhance operations and drive digital transformatio...
3 days ago
Associate Director, Strategic Program Management
$150K - $195K *
Contribute to the success of IVD and CDx programs by leading cross-functional teams through development, validation, and submission processes. Drive strategic execution and ensure alignment with regul...
Yesterday
Senior Director / Director , Breast Oncology Lifecycle Management
$186K - $233K *
Pioneer innovative strategies in breast oncology, driving commercial success through collaboration and data-driven insights. Lead cross-functional teams to enhance product adoption and optimize market...
3 weeks ago
Scientist II - Analytical Chemist
$80K - $95K *
Join a dynamic team to advance analytical chemistry methods and lead projects. Utilize your expertise in LC-MS for bioanalytical applications while mentoring junior scientists and driving innovation i...
4 days ago
Manager, Professional Services Federal
$128K - $160K *
Drive operational excellence and customer satisfaction by managing services teams, optimizing project delivery, and enhancing client engagement strategies for government clients, ensuring alignment wi...
Reposted 2 days ago
Senior Computer System Validation Specialist
$105K - $130K *
Optimize validation strategies and ensure compliance for GxP-regulated systems. Lead risk assessments, mentor junior team members, and oversee quality assurance activities throughout the system lifecy...
Reposted 2 weeks ago
Senior Project Manager - Health & Life Sciences Market Research (Remote, US-based only)
$85K - $110K *
Optimize project delivery by leading complex life sciences research initiatives, ensuring timely execution, quality standards, and effective vendor management while collaborating with cross-functional...
1 week ago
Sr. Health Systems Executive - Share of Wallet
$130K - $215K *
Unlock potential by driving organic growth in strategic accounts through deep relationships, cross-portfolio selling, and long-term planning to maximize revenue and customer retention while navigating...
Reposted 3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.