Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Nurse Practitioner / Physician Assistant - Texas
$140K - $150K *
Join a team that's dedicated to transforming addiction treatment through telehealth. Collaborate with physicians to provide comprehensive care for patients with substance use disorders, ensuring a sup...
6 days ago
$150K - $185K *
Shape strategic success for key accounts by leading market access initiatives, collaborating with cross-functional teams, and driving growth through innovative solutions and insights in the managed ma...
3 weeks ago
$110K - $130K *
Unlock compensation strategies by partnering with teams to analyze, model, and deliver data-driven solutions. Drive benchmarking, job architecture, and annual comp cycles to ensure equitable pay pract...
3 weeks ago
Dentist (Associate Dentist) - Private Practice - Advance, MO
$200K - $250K *
Empower patient care by joining a dedicated dental team focused on providing quality services to adults and children. Enjoy a supportive environment with flexible hours and competitive compensation, f...
1 week ago
Senior Pricing Analyst - Material Cost Estimator
$79K - $103K *
Transform cost estimation processes by collaborating with multifaceted teams to deliver precise material pricing for DoD proposals, ensuring compliance and competitiveness while supporting strategic d...
Reposted 1 week ago
Clinical Research Associate, Sponsor Dedicated
$74K - $197K *
Advance your career by ensuring compliance and quality in clinical trials. Conduct site monitoring, manage study progress, and collaborate with teams to enhance recruitment and data integrity while ad...
3 weeks ago
Clinical Research Associate, Sponsor Dedicated
$74K - $197K *
Lead the charge in site management and monitoring to ensure compliance with study protocols and regulations, enhancing data integrity and subject recruitment while collaborating with study teams for s...
3 weeks ago
Clinical Research Associate, Sponsor Dedicated
$74K - $197K *
Advance your career by ensuring compliance and quality in clinical trials. Conduct site monitoring, manage study progress, and collaborate with teams to enhance recruitment and data integrity while ad...
3 weeks ago
Biostatistical Programming Manager
$129K - $174K *
Lead a dynamic programming team to enhance data analysis strategies, ensuring high-quality biomedical data presentation while driving efficiency and innovation in a collaborative environment focused o...
1 week ago
Enterprise Account Executive, Michigan
$300K - $350K *
Empower your career by driving sales growth in the cybersecurity sector. Build strong customer relationships, acquire new accounts, and exceed sales quotas while managing Channel Partner relationships...
5 days ago
Lead Clinical Pharmacist, Oncology Programs
$120K - $145K *
Join a team that's redefining oncology care by overseeing clinical standards, evaluating therapies, and engaging with providers. You'll play a key role in shaping patient eligibility and treatment pro...
3 weeks ago
$100K - $120K *
Join a team that's dedicated to delivering exceptional inpatient care for adult patients. Utilize your advanced skills as a Nurse Practitioner or Physician Assistant in a collaborative environment, en...
2 weeks ago
Dir, Thought Leader Liaison (Oncology)
$203K - $245K *
Unlock potential by leading a national team of Thought Leader Liaisons to enhance KOL engagement and advocacy in oncology. Drive strategic initiatives, foster collaboration, and ensure compliance whil...
Reposted 1 week ago
Sr. Revenue Accountant/Analyst
$80K - $95K *
Drive the month-end close process by ensuring accurate revenue recognition and analysis. Collaborate across departments to produce insightful reports and support financial decision-making while adheri...
2 weeks ago
$115K - $145K *
Transform business operations by developing and deploying AI solutions that enhance product capabilities and customer experiences. Collaborate with cross-functional teams to integrate machine learning...
Today
Consultant Relations Senior Manager
$170K - $200K *
Elevate our Enterprise business by building impactful relationships with brokers and consultants. Drive engagement strategies, generate new business opportunities, and enhance BetterHelp's presence in...
3 weeks ago
Workday HCM Optimization Manager
$118K - $196K *
Deliver optimized Workday solutions through assessments, deployments, and client engagements. Lead design sessions, streamline processes, and enhance customer satisfaction in a collaborative and innov...
Reposted 2 weeks ago
Director, Diagnosis-Related Group Validation (DRGV)
$125K - $150K *
Unlock your potential by leading the development of innovative DRGV services, enhancing billing and coding optimization. Collaborate across teams to create scalable solutions that drive operational ex...
3 weeks ago
Senior Java Developer - Healthcare / PBM Platform
$96K - $125K *
Join a team that's dedicated to building high-performance Java applications for healthcare. Collaborate in Agile environments to design scalable microservices and troubleshoot complex issues, driving...
1 month ago
Revenue Cycle Managed Services - Billing Manager (Hospital System)
$100K - $120K *
Transform billing operations by leading a team to optimize healthcare revenue cycle processes, ensuring timely and accurate claims submission while driving performance improvements and fostering stron...
2 weeks ago
Product Manager - Vendor Oversight
$113K - $197K *
Lead the charge in defining product strategy and roadmap, translating business objectives into actionable plans. Collaborate with cross-functional teams to ensure successful implementation and operati...
2 weeks ago
$85K - $100K *
Join a team that's dedicated to delivering high-quality, patient-centered care in Interventional Radiology. Collaborate with healthcare professionals to evaluate patients, perform procedures, and supp...
4 days ago
$90K - $110K *
Join a dedicated team of professionals providing comprehensive advanced practice nursing for acute and chronic pain management. Collaborate in a multidisciplinary environment to deliver high-quality...
Reposted 3 weeks ago
Associate Director, Compliance
$110K - $130K *
Drive the enhancement of Compliance Monitoring and Testing programs, ensuring regulatory alignment and effective risk management. Collaborate with stakeholders to improve operational efficiency and su...
2 weeks ago
$170K - $210K *
Join a dynamic team to develop transformative brand strategies that inspire clients and drive impactful campaigns. Collaborate across functions to deliver insights and solutions that elevate brand per...
4 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.