Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$109K - $128K *
Unlock your potential as you design, build, and maintain full-stack web applications, collaborating across teams to deliver secure, reliable, and user-centered solutions that drive organizational succ...
4 days ago
$87K - $157K *
Champion operational excellence by leading cross-functional teams to enhance business strategies and drive data-driven insights, ensuring quality and efficiency in regulated communications. Grow your...
Reposted today
Lead Security Operations Analyst
$110K - $130K *
Engage in a dynamic role leading security operations and AI integration. Oversee real-time threat monitoring and incident response while developing automated workflows in a cutting-edge, multi-tenant...
1 week ago
$95K - $115K *
Transform healthcare by leading a dynamic radiology team, driving innovation and operational excellence while enhancing patient care across multiple modalities in a collaborative environment...
2 weeks ago
$153K - $171K *
Join a dynamic team to orchestrate complex technical programs, driving alignment and clarity across product and engineering. Empower teams to deliver impactful outcomes while leveraging AI insights fo...
Today
Senior Advisor, Vaccine & Clinical Case Management
$91K - $151K *
Shape the future of public health by leading the development of a statewide vaccine management and clinical case management system, ensuring seamless integration and support for local health departmen...
2 weeks ago
Nurse Manager II - 3rd Floor Tower Cardiac - Full Time
$80K - $95K *
Lead and transform patient care by utilizing the nursing process to assess, plan, and implement effective care strategies. Oversee operational excellence and foster innovation within the department to...
2 weeks ago
Director, Claims Process Optimization ( Facets Required)
$113K - $197K *
Drive automation and AI initiatives in claims operations, enhancing efficiency and accuracy. Lead a team to optimize workflows, manage vendor performance, and ensure compliance while delivering measur...
2 weeks ago
Lead Audit Services Consultant
$100K - $120K *
Oversee consulting engagements to assess risks in processes and controls. Act as a subject matter expert in financial, operational, and IT audits, providing advisory services and enhancing audit funct...
2 weeks ago
Associate Director, Real-World Analytics Programming
$186K - $233K *
Empower the future of real-world analytics by leading programming activities for observational studies, ensuring high-quality deliverables through collaboration with cross-functional teams and innovat...
3 weeks ago
$80K - $135K *
Advance educational research by analyzing data and synthesizing findings to enhance student access to advanced courses. Collaborate with stakeholders to design studies, build dashboards, and communica...
2 weeks ago
Associate Director, Regional Marketing (Midwest Region)
$120K - $145K *
Join a team that's driving regional marketing initiatives in hematology and oncology. Engage with key thought leaders, execute strategic plans, and leverage local opportunities to enhance brand presen...
3 weeks ago
Enterprise Applications Architect
$116K - $155K *
Transform enterprise applications through strategic architecture, integration, and governance. Collaborate with stakeholders to enhance business processes and ensure reliable operation of platforms wh...
Today
National Quality Performance Manager - HEDIS (Remote)
$90K - $110K *
Champion quality performance initiatives by collaborating across departments to enhance healthcare outcomes through data analysis, project management, and compliance with regulatory standards, ensurin...
2 weeks ago
Information Security Architect - AI
$170K - $212K *
Elevate AI security by designing robust frameworks to protect systems from threats. Collaborate with cross-functional teams to ensure compliance and ethical use, while implementing strategies that saf...
3 weeks ago
$182K - $198K *
Build and lead a robust Service Management Office to enhance IT operations, ensuring effective governance, accountability, and continuous improvement across a complex 24x7 environment, while fostering...
2 weeks ago
$88K - $105K *
Join a dynamic team as you lead HR initiatives, fostering a high-performance culture that empowers employees and drives organizational success. Collaborate with leadership to enhance recruitment, trai...
Reposted 2 days ago
Staff Software Engineer, New Products
$130K - $155K *
Unlock potential by rapidly transforming customer insights into innovative prototypes. Collaborate with a dynamic team to build scalable products from scratch, leveraging AI tools and existing platfor...
1 week ago
Staff Product Manager, Longitudinal Patient Record
$188K - $245K *
Drive the vision for a unified longitudinal patient record, ensuring data accuracy and completeness across multiple sources. Collaborate with cross-functional teams to enhance clinical data utility an...
Yesterday
Senior Financial Analyst (Consolidation)
$100K - $120K *
Lead the consolidation of financial models and metrics, partnering with cross-functional teams to deliver actionable insights and support strategic decision-making across the organization...
1 week ago
Life Sciences Commercial, Management Consulting Principal Director
$150K - $375K *
Join a team that's transforming life sciences through strategic commercial leadership. Drive large-scale engagements, foster client relationships, and deliver innovative solutions that enhance operati...
2 weeks ago
Capture Director, Medicaid Proposals
$100K - $231K *
Unlock potential by leading strategic capture management initiatives, collaborating with cross-functional teams to enhance proposal quality and win probability in Medicaid managed care. Drive innovati...
Reposted yesterday
People Program Manager, Payroll
$109K - $144K *
Join a team that's driving strategic payroll initiatives and enhancing operational effectiveness. You'll lead program execution, optimize Workday Payroll systems, and foster collaboration across depar...
Today
Senior Consultant - Regulatory
$110K - $130K *
Shape client success by leading complex consulting projects, integrating diverse workstreams into actionable insights, and driving high-quality deliverables while fostering team growth and managing st...
Reposted 1 week ago
Vice President, Global Therapeutic Area Leader, Oncology
$200K - $450K *
Inspire innovation in global therapeutic strategies, leading scientific expertise and operational execution across a diverse therapeutic landscape, while ensuring high-quality delivery and compliance...
Reposted yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.