Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
National Account Director, Enterprise Access
$240K - $269K *
Advance your career by leading national account strategies in oncology, fostering relationships with health plans and PBMs. Drive coverage, reimbursement, and adoption initiatives while collaborating...
2 weeks ago
Finance Consultant, Deltek Vision/Vantagepoint
$100K - $130K *
Unlock potential by partnering with clients to deliver tailored finance solutions, optimizing system performance, and enhancing project management activities. Leverage your expertise to drive client s...
Yesterday
Senior Project Manager (Neuroscience)
$122K *
Elevate your career by managing global projects in Neuroscience, ensuring compliance, budget adherence, and successful collaboration across cross-functional teams to drive milestone achievement and en...
Reposted 4 weeks ago
Analyst I, Falcon Complete GovCloud (Hybrid, St. Louis)
$85K - $120K *
Unlock potential in cybersecurity by engaging in real-time incident response and threat detection for government organizations. Develop your skills in a compliance-driven environment while protecting...
Yesterday
$210K - $250K *
Champion high-quality inpatient care as a Board-Certified Internal Medicine Hospitalist. Enjoy a 7-on/7-off schedule, competitive compensation, and a collaborative environment focused on clinical exce...
1 week ago
Associate Director Epidemiology
$156K - $234K *
Lead strategic epidemiological initiatives in oncology and neurology, driving evidence generation and operational execution for non-interventional studies. Collaborate cross-functionally to support cl...
4 days ago
Nurse Practitioner, HouseCalls - Clay and Jackson Counties, MO
$109K - $164K *
Transform healthcare delivery by conducting in-home assessments, improving member health outcomes through education and collaboration with primary care providers. Enjoy flexible scheduling and a suppo...
3 weeks ago
$95K - $115K *
Execute comprehensive project controls to ensure timely, budget-compliant project completion. Collaborate with teams to analyze financial data, manage forecasts, and report on project progress across...
2 weeks ago
$115K - $135K *
Drive your career forward by managing a diverse portfolio of high-net-worth clients, delivering expert tax preparation and advisory services while collaborating with financial advisors to maximize cli...
1 week ago
Associate Director, Client Engagement
$100K - $120K *
Manage a team of engagement managers to enhance operational effectiveness, drive project execution, and implement innovative solutions. Oversee financial performance and resource allocation while fost...
2 weeks ago
Senior Advisor, Budgeting & Resource Planning
$124K - $153K *
Transform financial management practices by leading budgeting, forecasting, and resource allocation efforts. Collaborate with teams to enhance decision-making and optimize financial systems, ensuring...
1 week ago
Manager, Client Strategy & Operations
$100K - $120K *
Join a team that's focused on enhancing client delivery and relationship growth. Drive data-driven strategies and cross-functional collaboration to optimize post-sale operations, ensuring exceptional...
Reposted 2 weeks ago
Senior Director for Advancement - Health System
$81K - $100K *
Transform your career by leading strategic fundraising initiatives, building relationships, and securing major gifts to support education, research, and patient care within a collaborative health syst...
1 week ago
$100K - $130K *
Transform healthcare by leading a dynamic PMO, ensuring program transparency and compliance across multiple customer accounts while fostering collaboration and continuous improvement...
1 week ago
Senior Director, Vendor Partnerships
$134K - $249K *
Shape the future of vendor management by leading strategic partnerships, ensuring compliance, and optimizing performance across dental, vision, pharmacy, and transportation services, all while managin...
Today
$275K - $350K *
Lead the charge in transforming operations by integrating AI and technology to enhance member and clinician experiences, ensuring efficient care delivery and operational excellence across a distribute...
Reposted yesterday
Director, Chronic Practice Liaison - Remote
$126K - $210K *
Lead strategic initiatives to enhance referral growth and provider engagement across chronic therapy markets. Drive collaboration among cross-functional teams to optimize patient progression and deliv...
4 weeks ago
Head of Business Development, Pharma/Life Sciences
$200K *
Transform the landscape of life sciences partnerships by driving co-developed deals. Leverage your extensive network and expertise to source, pitch, and close high-value agreements that enhance patien...
6 days ago
$95K - $115K *
Transform liquidity management and risk strategies while leading cash forecasting and funding initiatives across multiple regulated entities. Drive process improvements and enhance operational efficie...
3 weeks ago
$85K - $100K *
Drive clinical excellence by partnering with agency leaders to assess, develop, and deliver tailored education programs for nursing staff, ensuring compliance and enhancing patient care across a netwo...
6 days ago
Customer Success Advisor, Health Plans
$147K - $232K *
Engage with key health-plan relationships to drive revenue retention and growth. Oversee a strategic portfolio, leveraging analytics and executive relationships to enhance member access and operationa...
3 weeks ago
Staff Decision Scientist, Advanced Analytics
$130K - $242K *
Lead advanced analytics initiatives to enhance MAU insights, driving growth through experimentation and causal inference. Collaborate across teams to establish standards and leverage AI for scalable s...
1 week ago
Life Sciences Solutions Engineer, AVP (Commercialization)
$171K - $383K *
Accelerate progress at the forefront of AI-driven solutions in Life Sciences. Lead transformative commercial operations, drive client engagements, and innovate strategies to enhance data and analytics...
1 week ago
Life Sciences Solutions Engineer, AVP (Commercialization)
$171K - $383K *
Engage in transformative AI and data solutions for Life Sciences, leading commercial operations and driving innovation. Shape strategies, manage client relationships, and build high-performing teams t...
1 week ago
Nurse Practitioner (NP) - Jefferson City, MO
$95K - $115K *
Transform patient care by joining a leading wound care group, where you’ll enjoy flexibility, autonomy, and a focus on clinical excellence without the burden of nights, weekends, or call duties...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.