Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Project Manager, Senior (Remote)
$114K - $155K *
Champion project success by leading medium to large-scale healthcare and technology initiatives, ensuring timely delivery within scope and budget while fostering collaboration among stakeholders and m...
Today
$184K - $230K *
Shape the future of product security by leading architecture reviews and risk mitigation strategies. Collaborate with engineering and compliance teams to embed security throughout the development life...
2 weeks ago
VP OF SALES - WEST COAST - HEALTHCARE
$160K - $200K *
Join a dynamic team as a senior leader driving profitable growth in healthcare services. Oversee sales strategy, lead a high-performing team, and collaborate across functions to deliver innovative sol...
Reposted 6 days ago
$90K - $120K *
Elevate your career by leading clients through the CMMC 2.0 compliance journey. As a key advisor, you'll translate complex regulations into actionable strategies, ensuring audit readiness and security...
3 weeks ago
Account Specialist, Urology - St. Louis, MO
$90K - $110K *
Join a team that's dedicated to promoting innovative products to community practices and health systems. Build and maintain relationships across various medical specialties while driving sales and pro...
3 weeks ago
Account Specialist, Urology - St. Louis, MO
$80K - $95K *
Accelerate progress at community practices and health systems by promoting products, building relationships, and delivering expert training to enhance sales performance and meet customer needs across...
3 weeks ago
$135K - $165K *
Pioneer operational excellence in Design leadership, managing workflows, prioritizing projects, and developing talent. Collaborate cross-functionally to enhance Design integration in AI-driven product...
1 week ago
Executive Events & Communications Manager
$122K - $155K *
Advance executive visibility and engagement by coordinating high-impact events and communications. Collaborate with senior leadership to enhance corporate reputation and strengthen stakeholder relatio...
Yesterday
$110K - $130K *
Partner with us to design and implement cloud-native data solutions, ensuring secure and reliable data exchange across platforms. Collaborate with teams to enhance data accessibility and support advan...
2 weeks ago
Grants Consultant - Scientific Research Focus
$82K - $110K *
Champion grant proposal excellence by collaborating with clients to enhance competitiveness in scientific research funding. Drive impactful outcomes through expert consulting, training, and proposal d...
2 weeks ago
$80K - $95K *
Engage in high-quality legal research to support law firm clients, focusing on intellectual property matters. Utilize advanced research tools to deliver accurate results and synthesize findings into a...
3 weeks ago
$146K - $190K *
Shape healthcare innovation by building full-stack systems that enhance user experience, drive outcomes, and leverage AI solutions while collaborating across teams to understand business needs and exe...
Reposted yesterday
$86K - $138K *
Grow your career by leveraging expertise in cloud platforms to design and implement robust enterprise solutions. Engage in strategic problem-solving and collaborate with teams to ensure operational ex...
Reposted 3 weeks ago
$85K - $100K *
Unlock potential by leading a dynamic team of operating room professionals, ensuring high-quality patient care and efficient surgical operations while fostering a collaborative environment for growth...
3 weeks ago
$108K - $157K *
Optimize data-driven strategies by transforming raw analytics into actionable insights. Collaborate with cross-functional teams to enhance marketplace dynamics and drive measurable business outcomes i...
2 weeks ago
Lead Business Strategy Analyst - Underwriting Measurement Strategist
$127K - $243K *
Elevate our underwriting strategy by leveraging data analytics to drive decision-making. Collaborate with cross-functional teams to develop metrics that enhance operational efficiency and optimize per...
6 days ago
$160K - $190K *
Empower your career by partnering with the Science Leadership Team to drive strategic initiatives, enhance operational effectiveness, and translate scientific vision into impactful outcomes across div...
2 weeks ago
Radiation Oncologist - Missouri Cancer Associates Osage Beach
$300K - $350K *
Join a team that's dedicated to providing exceptional cancer care while enjoying a vibrant lifestyle in a premier resort destination. Collaborate with a skilled group of oncologists and contribute to...
Yesterday
Associate Director, Industry Technology Strategist - Enterprise
$201K - $239K *
Lead the charge in driving high-value sales pursuits, orchestrating teams and resources to shape winning strategies. Influence market offerings and account growth while championing excellence in clien...
3 weeks ago
$110K - $130K *
Join a dynamic team as a Dynatrace Administrator, optimizing environments and automating incident responses. Leverage your expertise to enhance performance monitoring and ensure seamless integration w...
1 week ago
$90K - $110K *
Drive growth in digital therapeutics by engaging medical practices, guiding them from initial interest to consistent orders. Collaborate with sales and clinical teams to shape the onboarding process a...
1 week ago
Senior Security Analyst – Cloud Security
$95K - $120K *
Transform cloud security operations by enhancing AWS and Azure environments. Lead initiatives to secure cloud-native capabilities, manage incident responses, and collaborate with engineering teams to...
3 weeks ago
Configuration Lead, Compensation
$117K - $161K *
Drive your career with this strategic role, leading Workday Compensation solutions. Collaborate with cross-functional teams to optimize compensation processes, ensuring alignment with business goals a...
5 days ago
Senior Business Analyst (MMIS Finance)
$85K - $111K *
Unlock your potential by leading business and functional requirements for Medicaid financial management. Collaborate with diverse teams to enhance payment operations and ensure compliance while drivin...
1 month ago
Senior Clinical Database Programmer - eCOA
$110K - $140K *
Champion the design and execution of eCOA studies, ensuring compliance and data integrity. Collaborate with cross-functional teams to deliver high-quality clinical outcomes while managing multiple pro...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.