Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Reinsurance and Statutory Capital Strategist
$175K - $250K *
Drive the development of innovative reinsurance strategies and statutory capital optimization. Lead cross-functional teams to enhance corporate solvency and risk-adjusted returns while managing regula...
2 weeks ago
Staff Machine Learning and Bioinformatics Scientist (Multi-Cancer Early Detection)
$163K - $204K *
Unlock potential by leading innovative machine learning methods for cancer detection, collaborating with experts, and mentoring junior scientists to advance research in multi-cancer early detection us...
3 weeks ago
Director, Utilization Management Operations
$182K - $247K *
Join a team that's redefining operational excellence in healthcare. Lead a diverse team to streamline utilization management processes, enhance technology integration, and drive measurable improvement...
3 days ago
$90K - $110K *
Join a dynamic team to develop and enhance SaaS applications, utilizing Agile methodologies. Collaborate with peers, support customers, and drive innovative solutions while staying updated on technica...
1 week ago
$105K - $126K *
Lead and optimize subcontract management by negotiating agreements, ensuring compliance, and collaborating with stakeholders to drive successful federal contracting outcomes while mentoring junior sta...
3 weeks ago
Enterprise Account Executive, Ohio Valley
$280K - $300K *
Advance your career with a high-impact sales role focused on driving new business and expanding relationships within large enterprise accounts, leveraging cutting-edge AI technology to deliver measura...
3 weeks ago
$130K - $155K *
Lead validation efforts for complex GxP computerized systems, ensuring compliance and quality. Collaborate with IT and QA, mentor junior staff, and execute risk-based project strategies to maintain in...
4 weeks ago
$80K - $95K *
Join a team that's dedicated to enhancing patient care by leading operations in hospice and palliative services. You'll oversee daily functions, ensure compliance, and drive growth through strategic i...
2 weeks ago
Senior Analyst, AML Investigations
$97K - $115K *
Unlock insights into financial crime by investigating complex AML cases, driving compliance initiatives, and collaborating with stakeholders to enhance detection models and operational efficiency in a...
1 week ago
Senior Analyst, Asset Based Lending Field Exam
$95K - $115K *
Lead the future of asset-based field examinations by delivering insightful analyses, evaluating financial controls, and ensuring compliance. Collaborate with clients to assess collateral values and mi...
1 week ago
$65K - $96K *
Join our team to manage complex compliance filings, ensuring accuracy and quality standards. You'll mentor others, review peer work, and develop processes to enhance service delivery within compliance...
Reposted 2 weeks ago
$65K - $96K *
Empower compliance processes by preparing complex government filings, mentoring team members, and ensuring accuracy, while maintaining high service standards and developing knowledge of intricate comp...
Reposted 2 weeks ago
Senior Strategic Account Executive, Private Equity Partnerships
$150K - $180K *
Empower growth by leading private equity partnerships, driving telehealth solutions across portfolios. Build relationships, negotiate agreements, and create a repeatable deployment model to enhance he...
2 weeks ago
$100K - $130K *
Drive credit risk assessments and limit approvals for institutional clients, enhancing reporting tools and compliance. Collaborate with teams to mitigate risks and improve efficiencies in a fast-paced...
4 weeks ago
Lead Technical Analyst - Real Estate Applications (Yardi)
$121K - $167K *
Lead the evolution of real estate applications by designing and implementing innovative technology solutions, enhancing system reliability, and driving proactive support across Yardi platforms and int...
2 weeks ago
$170K - $200K *
Drive exceptional anesthesia care in a modern outpatient setting while enjoying autonomy and a predictable schedule. Collaborate closely with a skilled team in a physician-led environment focused on h...
Reposted today
$110K - $130K *
Shape the future of secure software development by integrating security practices into engineering workflows, building automation tools, and conducting penetration tests to identify vulnerabilities an...
2 weeks ago
Director, Data & Distribution Partnerships
$190K - $275K *
Advance the Data & Distribution Partnerships function by innovating and scaling data reseller and distribution models, building commercial arrangements, and leading a team to create revenue-generating...
Reposted 3 weeks ago
$130K - $160K *
Empower the development of mission-critical applications on the ServiceNow platform, collaborating with stakeholders to deliver scalable solutions while ensuring compliance with federal standards and...
3 weeks ago
$69K - $105K *
Elevate your research career by conducting impactful studies that enhance crisis services. Collaborate with experts to analyze data, develop tools, and contribute to vital evaluations that support the...
Reposted 2 weeks ago
Operations Support & Strategy Manager
$109K - $144K *
Join a dynamic team to drive operational excellence and process improvements in healthcare. Lead complex initiatives, influence strategy, and enhance care delivery while collaborating across multiple...
1 week ago
Territory Manager (North Carolina)
$80K - $95K *
Grow your career by managing a dynamic sales territory, driving revenue, and building relationships within the medical community. Leverage your expertise to educate clients and expand business opportu...
2 weeks ago
Strategy & Operations - Coding Optimization and Automation Consultant
$125K - $235K *
Champion healthcare coding excellence by optimizing operations, implementing automation, and enhancing training. Collaborate with leaders to drive measurable improvements in productivity and accuracy...
3 weeks ago
Hemostasis Sales Specialist - East Texas Region
$99K - $136K *
Join a dynamic team as a strategic growth architect, driving revenue and market share expansion in the Hemostasis portfolio. Leverage your expertise in complex healthcare sales to influence decision-m...
3 weeks ago
Account Manager, Life Science, Public Health Labs (East Coast)
$105K - $120K *
Engage with public health labs to enhance customer satisfaction and drive sales. Collaborate with cross-functional teams to execute market strategies and foster relationships with key opinion leaders...
6 days ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.