Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Clinical Applications Specialist, Invasive Cardiology
$92K - $138K *
Help us enhance clinical education by delivering expert training and support to healthcare professionals. Drive product adoption and optimize user competencies while fostering strong relationships wit...
3 weeks ago
Senior Business Intelligence Analyst
$135K - $150K *
Join a team that's redefining business intelligence through Power BI. You'll develop impactful reports and dashboards, enhance client-facing platforms, and ensure data integrity while collaborating wi...
6 days ago
Clinical Quality & Regulatory Leader
$110K - $125K *
Drive clinical quality and regulatory excellence across regions by managing incidents, analyzing data, and implementing improvements. Collaborate with leaders to enhance safety and compliance, ensurin...
4 days ago
Director, Patient Access (Travel)
$92K - $125K *
Drive operational excellence in patient access by leading teams, enhancing processes, and fostering collaboration across healthcare facilities. Your leadership will ensure compliance, improve patient...
6 days ago
Communications Specialist, Education Systems & Policy
$96K - $102K *
Join a dynamic team to develop and implement strategic communications initiatives that translate complex research into engaging content for diverse audiences, enhancing visibility and impact across ed...
1 week ago
$200K - $245K *
Join a team that's dedicated to providing expert employment counsel across a global workforce. You'll partner with business leaders to navigate complex employment issues, ensuring sound legal advice t...
Reposted 3 weeks ago
Senior Software Engineer II - Agentic SDLC
$170K - $185K *
Champion innovative software solutions by leading complex projects, mentoring engineers, and driving technical excellence across teams. Collaborate on strategic initiatives to enhance reliability and...
1 week ago
$110K - $160K *
Join a dynamic team of engineers to develop innovative software solutions, enhance user experiences, and drive impactful projects. Collaborate across functions while embracing modern technologies and...
3 weeks ago
$120K - $140K *
Lead the charge in implementing and maintaining ISO 27001:2022 compliance, driving cross-functional initiatives, and enhancing the Information Security Management System while collaborating with diver...
1 week ago
$134K - $249K *
Champion strategic vendor partnerships and enterprise initiatives, overseeing evaluations, negotiations, and performance metrics to drive clinical, operational, and financial success across multiple t...
Today
Market Research Director or Senior Director- For Future Consideration
$100K - $150K *
Elevate your career by leading innovative research initiatives that shape industry strategies. Collaborate with top brands, utilizing your expertise in qualitative and quantitative methods to deliver...
2 weeks ago
$200K - $350K *
Join a dynamic team focused on wound management, offering flexible schedules and no weekend or night shifts. Enjoy clinical autonomy while providing expert care in various facilities, with comprehensi...
1 week ago
Pharmacy Strategy Advancement Advisor
$115K - $158K *
Join a dynamic team to provide strategic direction and data-driven insights, addressing complex business challenges in healthcare. Lead initiatives that enhance consumer experiences while collaboratin...
Yesterday
$80K - $95K *
Tackle critical cybersecurity challenges as an Information Assurance Analyst, ensuring compliance and security for key Army systems. Collaborate with technical teams to conduct vulnerability assessmen...
5 days ago
$144K - $195K *
Elevate healthcare analytics by leading reporting initiatives that enhance patient care across 600+ facilities. Collaborate with stakeholders to implement innovative solutions and ensure compliance in...
3 days ago
$100K - $120K *
Elevate patient care by assessing and managing medication therapy in a collaborative environment. Contribute to a dedicated pharmacy team, ensuring optimal drug use and safety while supervising suppor...
Today
$110K - $130K *
Join a team that's dedicated to enhancing patient care through innovative pharmacy practices. Collaborate with healthcare professionals in a dynamic environment, ensuring optimal medication management...
4 days ago
$100K - $120K *
Transform patient care by assessing and managing medication therapy in a collaborative environment. Leverage your clinical expertise to enhance safety and efficiency while supervising pharmacy staff a...
1 week ago
$110K - $130K *
Join a team that's dedicated to enhancing patient care through clinical pharmacy expertise. Collaborate with healthcare professionals to optimize medication therapy and ensure safe, effective drug use...
1 week ago
RN Nurse Clinical Documentation Improvement Specialist
$114K *
Advance clinical documentation quality by conducting thorough reviews and facilitating physician interactions to enhance accuracy and compliance in medical records, ensuring optimal patient care and r...
1 week ago
$90K - $100K *
Analyze sales data and trends to support the sales team, optimize performance, and drive strategic decision-making. Collaborate across departments to enhance processes and deliver impactful reports an...
6 days ago
Program Analyst (Springfield VA)
$120K - $130K *
Transform the future of geospatial intelligence by supporting R&D program planning, financial execution, and acquisition activities. Collaborate with diverse teams to ensure effective management of fu...
1 week ago
$100K - $120K *
Partner with us to drive revenue growth and strategic account management across a diverse portfolio. You'll own the full sales cycle, collaborate with cross-functional teams, and build lasting relatio...
3 weeks ago
Sales Incentive Compensation Data Analyst
$73K - $109K *
Take ownership of data governance and reporting for sales incentive programs, ensuring accurate performance data translates into meaningful payouts. Collaborate with teams to drive sales behavior thro...
4 days ago
$100K - $120K *
Unlock potential by delivering comprehensive health assessments in patients' homes. This role requires extensive travel within a region, ensuring quality care and education while collaborating with he...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.