Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$88K - $105K *

Join a dynamic team to optimize Oracle applications, analyze user needs, and design effective system solutions. Leverage your expertise to enhance operational efficiency and support mission-driven ini...

United StatesRemote

Today

  •   5 - 7 years exp.  •   Information Technology

$100K - $120K *

Shape the future of healthcare facilities by ensuring compliance, safety, and comfort in rehabilitation environments. Lead maintenance programs and foster an inclusive culture while enhancing patient...

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$72K - $104K *

Lead the charge in enhancing customer care quality through effective monitoring, collaboration, and continuous improvement initiatives. Drive actionable insights and training to elevate service standa...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Pharmaceuticals & Biotech

$128K - $150K *

Help us drive growth in the Home Health and Pediatric Care sectors by generating new enterprise revenue. Own the full sales cycle, engage decision-makers, and develop strategic relationships to establ...

United StatesRemote

Reposted 1 month ago

  •   5 - 7 years exp.  •   Enterprise Technology

$85K - $161K *

Elevate enterprise AI solutions by deploying, securing, and scaling AI assistants. Collaborate with clients to ensure readiness and optimize their AI journey from experimentation to production, enhanc...

5 days ago

  •   Less than 5 years exp.  •   Finance & Insurance

$90K - $110K *

Transform patient care by joining a leading wound care group, where you’ll enjoy a flexible practice environment, collaborate with expert peers, and focus on delivering exceptional care without the bu...

3 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $195K *

Drive impactful data science initiatives by building and operating ML systems. Manage end-to-end processes from modeling to evaluation, while mentoring a lean team and collaborating across departments...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Hospitality & Recreation

$300K - $350K *

Join a team that's driving sales growth in the cybersecurity sector. This role focuses on acquiring new accounts, building customer relationships, and ensuring satisfaction while exceeding sales quota...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Information Technology

$80K - $95K *

Champion exceptional research outcomes by guiding clients through complex projects. Leverage your expertise in methodology and analysis to deliver actionable insights, while collaborating with cross-f...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Information Technology

$85K - $165K *

Champion safety in innovative nuclear fuel recycling by evaluating hazards, developing safety documents, and ensuring compliance with regulations. Collaborate in a dynamic team to enhance safety measu...

RemoteRemote

4 weeks ago

  •   Less than 5 years exp.  •   Energy & Utilities

$95K - $115K *

Drive data-driven decision-making by transforming complex data into actionable insights. Collaborate with cross-functional teams to enhance reporting and analytics using advanced SQL and AI tools, ens...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Retail & Consumer Goods

$110K - $130K *

Drive governance and controllership for LTC actuarial models, ensuring compliance and effective controls. Collaborate with cross-functional teams to enhance processes and documentation, supporting mod...

RemoteRemote

3 weeks ago

  •   5 - 7 years exp.  •   Finance & Insurance

$120K - $145K *

Unlock the potential of data as a senior data scientist, transforming U.S. Army enterprise data into impactful analytical products and workflows, while collaborating with cross-functional teams to dri...

United StatesRemote

3 weeks ago

  •   8 - 10 years exp.  •   Information Technology

$90K - $110K *

Champion clinical education and training by delivering expert knowledge and support to enhance user competencies and optimize patient care within a defined territory. Build strong relationships with s...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Business Services

$100K - $120K *

Drive excellence in medication management by preparing, dispensing, and evaluating drug therapies. Collaborate with healthcare teams to enhance patient outcomes and ensure safe medication practices in...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$92K - $146K *

Support a dynamic pediatric orthopedic team by providing surgical assistance and inpatient care for diverse pediatric patients, ensuring high-quality, family-centered treatment in a collaborative envi...

1 week ago

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Lead the development of our observability practice, creating dashboards and alerting systems to ensure uptime and reliability across enterprise tools. Build visibility from scratch, automate processes...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$73K - $115K *

Unlock the potential of clinical documentation integrity by driving ICD-10-CM coding accuracy and enhancing provider education. Collaborate with cross-functional teams to support risk adjustment initi...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$180K - $220K *

Empower innovation in clinical trials by developing strategies, overseeing operations, and cultivating partnerships. Drive excellence in research, enhance compliance, and manage a high-performing team...

RemoteRemote

Reposted 1 week ago

  •   8 - 10 years exp.  •   Hospitals & Medical Centers

$110K - $130K *

Elevate your career by partnering with sales teams to drive analytics and AI revenue. Leverage your expertise to accelerate deal closure, generate new opportunities, and empower field teams with strat...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Enterprise Technology

$140K - $185K *

Unlock the power of enterprise data as you design and implement Master Data Management solutions that enhance healthcare operations, drive analytics, and enable AI-driven decision-making with trusted...

RemoteRemote

Reposted 3 weeks ago

  •   8 - 10 years exp.  •   Healthcare

$135K - $160K *

Unlock potential by leading analytics and performance management initiatives that drive strategic business outcomes. Transform data into actionable insights, ensuring effective governance and alignmen...

Yesterday

  •   11 - 15 years exp.  •   Finance & Insurance

$110K - $130K *

Transform customer relationships by architecting end-to-end success strategies for enterprise accounts. Lead high-impact engagements, drive growth, and shape product strategy in a dynamic and collabor...

United StatesRemote

Reposted yesterday

  •   8 - 10 years exp.  •   Healthcare

$101K - $197K *

Lead the development and execution of strategic sales initiatives to enhance market share and client relationships within designated therapeutic areas, ensuring alignment with organizational goals and...

United StatesRemote

Reposted 3 weeks ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$73K - $87K *

Unlock potential by driving transformation through emerging technologies. Collaborate with stakeholders to analyze, prototype, and implement AI solutions that address real-world challenges, ensuring h...

3 days ago

  •   Less than 5 years exp.  •   Real Estate & Construction

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.