Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Nurse Practitioner or Physician Assistant - F/T or P/T - Hazelwood Florissant Internal Medicine
$95K - $125K *
Transform patient care by providing comprehensive primary services in a supportive, collaborative environment. Enjoy flexible scheduling with no nights or weekends while focusing on preventive care an...
4 weeks ago
Senior Bioinformatics & Genomics Data System Engineer
$113K - $142K *
Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...
6 days ago
Nurse Practitioner or Physician Assistant for Cardiology at Barnes-Jewish St. Peters
$95K - $115K *
Manage acute and chronic patient care in specialty services, performing assessments and developing treatment plans in both ambulatory and hospital settings, while collaborating with physicians to ensu...
1 week ago
Senior Data Engineer, HR Data & Analytics
$122K - $213K *
Transform data solutions by designing and optimizing scalable pipelines that empower analytics and decision-making across the organization. Collaborate with stakeholders to deliver high-performance da...
Reposted today
$89K - $113K *
Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...
1 week ago
$140K - $170K *
Elevate your career by managing a dynamic Palliative Care Program, providing clinical expertise, and leading a dedicated team. Drive process improvements and ensure high-quality patient care while fos...
3 weeks ago
$110K - $130K *
Lead a dynamic SOC team as a Senior Cybersecurity Analyst, enhancing threat detection and incident response through AI and machine learning. Drive security improvements and mentor team members while s...
2 weeks ago
$68K - $143K *
Unlock innovative financial processes by driving transformation in logistics integration and optimizing resource allocation. Collaborate with diverse teams to enhance financial operations within the D...
Reposted 1 week ago
Senior Manager, Medicare Product & Market Intelligence
$129K - $168K *
Support the strategic development and execution of Medicare growth initiatives, guiding teams in product strategy, competitive analysis, and bid management to drive profitable growth and successful ma...
Reposted yesterday
$113K - $188K *
Join a dynamic team to design and develop high-performance ETL solutions, integrating data from diverse sources. Collaborate with cross-functional teams to optimize data workflows and ensure complianc...
3 weeks ago
$95K - $115K *
Unlock potential by leading a team of Business Analysts to drive strategic initiatives, enhance stakeholder engagement, and operationalize an embedded BA model, fostering growth and transformation wit...
1 week ago
$118K - $196K *
Elevate your career as a key member of an agile software engineering team, driving the design and development of scalable applications. Collaborate across all stages of the software lifecycle to deliv...
Reposted yesterday
$110K *
Take ownership of complex mortgage loan evaluations, ensuring compliance with guidelines while assessing borrower risk. Collaborate with internal teams and vendors to facilitate loan approvals and mai...
2 weeks ago
$115K - $130K *
Analyze market trends and performance metrics to drive actionable insights across marketing, sales, and revenue operations. Collaborate with cross-functional teams to optimize strategies and enhance g...
1 week ago
$75K - $96K *
Optimize AI triage and automation processes while engineering secure data pipelines. Collaborate with teams to enhance security alert resolution and streamline workflows, ensuring effective integratio...
1 week ago
$75K - $96K *
Unlock your potential as a key player in our overnight security operations, enhancing AI-driven incident response and automation. Your expertise will shape how we detect and respond to threats, ensuri...
1 week ago
$72K - $107K *
Join a team that's dedicated to enhancing resident development through effective program management, collaboration with clinical leaders, and innovative professional development sessions to ensure a s...
5 days ago
$122K - $184K *
Drive operational excellence by leading physician practices in Ohio. Collaborate with clinical and regional teams to enhance performance, accountability, and patient experience while translating data...
2 weeks ago
Provider Clinical Operations Consultant, Senior Manager
$124K - $280K *
Drive clinical modernization initiatives in healthcare, leading multidisciplinary teams to enhance operations, technology workflows, and patient access while advising on transformation strategies and...
Today
Lead Director - Digital Product (Causal Analytics)
$144K - $288K *
Empower product innovation by leading analytics development, defining strategies, and collaborating with cross-functional teams to enhance patient care and drive impactful solutions in a dynamic envir...
Reposted 1 week ago
$68K - $113K *
Join a team that's dedicated to transforming disability claims through expert clinical assessments. Collaborate with healthcare providers and utilize your clinical expertise to improve patient outcome...
Reposted 3 weeks ago
Director - Data & AI Solutions - Financial Services, Actuarial - REMOTE
$122K - $182K *
Unlock potential by leading enterprise-scale data and AI solutions, modernizing actuarial processes, and driving cloud-native transformations. Collaborate with stakeholders to enhance decision-making...
2 weeks ago
Advisor II, Health Supply Chain, Continuity of Integrated Health Services (CIHS) Project
$80K - $95K *
Empower global health initiatives by enhancing supply chain systems across multiple countries. Collaborate with teams to ensure compliance, efficiency, and capacity building in logistics and procureme...
2 weeks ago
$76K - $115K *
Optimize billing operations and enhance contract management by collaborating cross-functionally. Drive accuracy in invoicing, support month-end close, and streamline processes to improve efficiency an...
4 days ago
Senior Associate, Corporate Development
$135K - $165K *
Elevate your career by driving strategic acquisitions and value creation in a dynamic environment. Collaborate with cross-functional teams to identify targets, lead transactions, and build frameworks...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.