Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
$90K - $110K *
Shape the future of consumer lending by analyzing credit risk and performance data to drive strategic insights for financial institutions, optimizing their underwriting processes and enhancing portfol...
Reposted 3 weeks ago
Technical IBM Mainframe Applications/Systems Analyst
$75K - $105K *
Optimize mainframe systems as a key analyst, ensuring stability and performance of IBM z/OS environments. Collaborate with teams to troubleshoot issues and maintain critical applications, while enhanc...
1 week ago
Cybersecurity A&A Risk Analyst
$110K - $112K *
Elevate your career by providing advanced governance, risk, and compliance support for federal information systems, ensuring compliance with federal laws and regulations while engaging with key stakeh...
3 weeks ago
Staff Software Engineer - Data Platform (HL7) (R37)
$212K - $409K *
Drive innovation as a key member of our engineering team, leveraging your expertise in software engineering and data platforms to shape solutions that enhance customer experiences and meet business go...
3 weeks ago
Senior Director, Corporate Relations- St Louis, MO
$115K - $150K *
Engage in strategic corporate partnerships to drive revenue growth and mission impact. Lead a team in cultivating executive relationships, securing multi-million dollar partnerships, and implementing...
2 weeks ago
Manager of Statistical Programming
$132K - $165K *
Drive innovation in oncology diagnostics by leading statistical programming efforts, ensuring data integrity and compliance for clinical trials, while managing a team and collaborating cross-functiona...
3 weeks ago
$100K - $120K *
Drive strategic oversight of enterprise-wide RAC audit activities, ensuring compliance and operational excellence. Collaborate with leadership to enhance audit processes, minimize financial risk, and...
2 weeks ago
Enterprise Service and Configuration Management Analyst
$66K - $106K *
Optimize IT service delivery by managing configuration items, analyzing operational data, and ensuring effective incident resolution. Collaborate with cross-functional teams to enhance service perform...
3 weeks ago
Nurse Practitioner or Physician Assistant - Pediatric Neurology - Mercy Hospital St. Louis
$95K - $115K *
Empower patient care by joining a collaborative team focused on pediatric neurology. This role offers a supportive environment for both seasoned professionals and those early in their careers, ensurin...
5 days ago
Associate - Financial Planning & Analysis (FP&A)
$80K - $95K *
Empower your career by driving financial insights and analytics. Collaborate across teams to transform data into strategic decisions, enhancing growth and efficiency in a dynamic environment. Join us...
1 week ago
$110K - $130K *
Join a team that's redefining report development for public safety platforms. Design and implement dynamic reports leveraging .NET technologies to provide insights that enhance operational decision-ma...
Reposted yesterday
Analyst I, Falcon Complete GovCloud (Hybrid, St. Louis)
$85K - $120K *
Drive security excellence by leveraging technical skills to protect government organizations from advanced threats. Engage in real-time incident response, monitoring, and analysis within a compliance...
Yesterday
$103K - $128K *
Join us to lead product strategy and development, driving innovation and performance in healthcare solutions. Collaborate cross-functionally to align business needs with customer expectations and ensu...
1 month ago
Nurse Practitioner or Physician Assistant - Gastroenterology Hospital Based - Springfield, MO
$95K - $115K *
Transform patient care by collaborating with a dedicated team of physicians and advanced practitioners in a dynamic hospital setting, focusing on quality and comprehensive gastroenterology services fo...
Reposted 5 days ago
$88K - $155K *
Empower clients by analyzing data to drive strategic improvements and enhance engagement. Collaborate with teams to develop innovative solutions, support project management, and foster relationships t...
Reposted today
Senior Consultant--Homelessness and Human Services
$80K - $135K *
Empower communities by leading strategic initiatives in homelessness services. Utilize your expertise to enhance organizational capacity, improve service coordination, and drive sustainable solutions...
1 week ago
$88K - $154K *
Transform your career by leading full-lifecycle recruiting for federal proposals, focusing on defense and intelligence sectors. Collaborate with teams to develop strategies, source talent, and ensure...
5 days ago
Senior Advisor, Federal Contracts - Evernorth Federal Services - Hybrid (MO)
$100K - $120K *
Transform federal contract administration by providing expert guidance and support throughout the acquisition lifecycle, ensuring compliance and efficiency while collaborating with cross-functional te...
Today
Project Manager, FEHRM Healthcare Technology Management - Deployment
$95K - $125K *
Drive the deployment of healthcare technology across multiple VA facilities, coordinating projects and ensuring readiness. Collaborate with diverse teams to manage timelines, resolve issues, and deliv...
3 weeks ago
Nurse Practitioner or Physician Assistant - F/T or P/T - Hazelwood Florissant Internal Medicine
$95K - $125K *
Transform patient care by providing comprehensive primary services in a supportive, collaborative environment. Enjoy flexible scheduling with no nights or weekends while focusing on preventive care an...
4 weeks ago
Senior Bioinformatics & Genomics Data System Engineer
$113K - $142K *
Elevate your career by joining our dynamic team to design, develop, and optimize bioinformatics software tools and systems, ensuring robust functionality and compliance in a fast-paced, innovative env...
6 days ago
Nurse Practitioner or Physician Assistant for Cardiology at Barnes-Jewish St. Peters
$95K - $115K *
Manage acute and chronic patient care in specialty services, performing assessments and developing treatment plans in both ambulatory and hospital settings, while collaborating with physicians to ensu...
1 week ago
$89K - $113K *
Transform data integrity by assisting in the analysis and cleansing of Enterprise Business Systems. Collaborate with teams to resolve anomalies and ensure compliance with DoD standards while supportin...
1 week ago
$140K - $170K *
Elevate your career by managing a dynamic Palliative Care Program, providing clinical expertise, and leading a dedicated team. Drive process improvements and ensure high-quality patient care while fos...
3 weeks ago
$110K - $130K *
Lead a dynamic SOC team as a Senior Cybersecurity Analyst, enhancing threat detection and incident response through AI and machine learning. Drive security improvements and mentor team members while s...
2 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.