Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Project Lead, Client Onboarding (Remote)
$88K - $105K *
Manage the end-to-end onboarding of healthcare clients, leading cross-functional teams to ensure smooth transitions into coding and billing services while driving operational improvements and maintain...
2 weeks ago
Director of Clinical Strategy - Compliance Suite (ControlCheck & PrivacyPro)
$130K - $150K *
Shape the future of healthcare technology by leading clinical strategy initiatives to enhance drug diversion prevention and ensure patient privacy compliance. Drive impactful relationships, educate st...
Reposted 3 weeks ago
Senior Pharmacist - Strategy (Hybrid)
$118K - $196K *
Lead the charge in developing and executing drug formulary strategies, ensuring compliance with regulations while collaborating with cross-functional teams to enhance pharmacy utilization management a...
3 weeks ago
Operations Business Analyst Sr
$75K - $122K *
Drive technology solutions for complex business projects, ensuring effective communication among stakeholders. Participate in all development lifecycle stages, providing expert advice on design and im...
Today
$86K - $138K *
Shape the future of technology by designing and optimizing architecture strategies that align with business needs. Collaborate across teams to ensure integrity and practicality in solutions, while lev...
Reposted yesterday
Senior Clinical/Operations Internal Monitoring Manager
$129K - $168K *
Optimize internal monitoring processes by leading clinical evaluations and audits across operational functions. Drive compliance, enhance decision-making, and foster team development to ensure alignme...
Reposted yesterday
Full-Stack Engineer - AI-Native Solutions
$98K - $163K *
Shape the future of enterprise software by building secure, scalable applications. Collaborate with cross-functional teams to integrate AI capabilities and deliver innovative solutions that meet busin...
Today
$94K - $130K *
Elevate product outcomes by collaborating with teams to prioritize and define user stories, ensuring alignment with business needs while maximizing value delivery and maintaining product quality throu...
6 days ago
$95K - $115K *
Unlock potential by designing and optimizing scalable data pipelines and infrastructure to support large datasets, ensuring efficiency and security across cloud and on-premises environments while prov...
Today
$95K - $115K *
Unlock potential by designing and optimizing data pipelines and infrastructure. Collaborate with cross-functional teams to enhance data delivery and support agency missions through scalable solutions...
Today
$95K - $115K *
Elevate your career by designing and optimizing data pipelines and infrastructure. Contribute to large-scale data systems that support critical agency missions, ensuring efficiency and security across...
Today
$95K - $115K *
Unlock potential by designing and optimizing data pipelines and infrastructure to support large datasets. Collaborate with cross-functional teams to enhance data delivery and ensure efficient, secure...
Today
Neurosurgery - Nurse Practitioner APN
$95K - $115K *
Drive comprehensive neurosurgical care for Veterans, collaborating with specialists to provide advanced assessments, treatment plans, and ongoing management in both outpatient and inpatient settings...
Today
$62K - $119K *
Join a team that's dedicated to enhancing billing processes and team development. Oversee daily operations, manage performance, and drive strategic improvements while supporting a dynamic billing depa...
4 days ago
Nurse Practitioner - Congestive Heart Failure
$95K - $115K *
Empower patients by leading the development of a new Congestive Heart Failure program. Collaborate with cardiology teams to enhance care pathways and improve outcomes for heart failure patients while...
2 weeks ago
$85K - $100K *
Lead the charge in delivering comprehensive primary care for patients ages 2+, focusing on prevention and wellness. Collaborate with a dedicated team to manage health conditions and empower patients t...
Today
$110K - $130K *
Elevate your career by architecting scalable analytics systems and AI-driven workflows that empower decision-making across our enterprise SaaS business, paving the way for innovation and growth in a d...
Reposted 6 days ago
Occupational Therapist Home Health
$80K - $95K *
Unlock potential by providing in-home occupational therapy services, evaluating safety, assessing functional needs, and implementing personalized treatment plans to enhance patient independence and qu...
2 weeks ago
Director, Workforce Management
$161K - $210K *
Elevate workforce management by leading recruitment, onboarding, and performance strategies. Drive clinician readiness and productivity while ensuring quality care through data-driven decision-making...
Reposted yesterday
Senior Compensation Consultant
$110K - $130K *
Lead complex compensation initiatives, ensuring equitable pay programs while managing projects. Serve as a subject matter expert in various compensation areas and collaborate with teams to enhance org...
Reposted 1 week ago
Business Analyst - Mortgage Technology - Remote US
$90K - $110K *
Join a team that's dedicated to enhancing system performance and quality. In this role, you'll analyze user requirements, collaborate with stakeholders, and drive technology solutions to optimize oper...
3 weeks ago
Director- Allied Health Programs
$80K - $90K *
Elevate healthcare education by leading the development of innovative allied health programs. Drive growth and improvement through strategic partnerships, curriculum design, and compliance, ensuring l...
3 weeks ago
Client Success Manager, Healthcare Revenue Cycle (West Coast candidates preferred!)
$95K - $115K *
Join a dynamic team as you drive client success in healthcare IT. Collaborate with cross-functional teams to enhance client experiences and optimize product usage, ensuring satisfaction and retention...
2 weeks ago
Physician Assistant (PA) - Jefferson City, MO
$90K - $110K *
Unlock potential by joining a leading wound care group, focusing on patient care with flexibility and work-life balance. Collaborate with expert peers and utilize advanced technologies in a supportive...
3 weeks ago
$70K - $205K *
Transform the landscape of digital forensics by leading complex investigations, developing innovative tools, and engaging with clients to deliver actionable insights that enhance security and response...
Yesterday
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.