Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
AI & GenAI Data Scientist-Director
$155K - $410K *
Shape the future of AI and data-driven solutions; lead innovative projects, mentor teams, and work with executives to transform insights into action, driving business growth in a dynamic environment w...
Reposted 3 weeks ago
$92K - $166K *
Unlock potential by leading logistics analysis and execution for naval programs, ensuring effective support for maintenance, training, and compliance in a dynamic environment. Collaborate with diverse...
Today
Senior Case Manager RN - Oncology (Remote)
$79K - $127K *
Partner with us to deliver comprehensive case management services, ensuring quality care and optimal health outcomes for members with complex needs. Collaborate with healthcare teams to develop and im...
4 weeks ago
$80K - $121K *
Transform patient care by leading an interdisciplinary team to ensure high-quality home health services, coordinating clinical operations, and adhering to regulatory standards for optimal patient outc...
3 days ago
Environmental Policy & Compliance Analyst
$100K - $150K *
Lead the charge in environmental policy analysis and compliance, ensuring adherence to NEPA and other regulations. Collaborate with agencies, conduct research, and draft reports to support sustainable...
1 week ago
$120K - $150K *
Champion social strategy and community engagement, driving impactful growth across multiple channels. Lead a dynamic team to create culturally relevant content, leveraging AI for efficiency and innova...
3 weeks ago
$90K - $110K *
Empower nursing excellence by leading clinical operations and quality initiatives. Drive resident outcomes and foster a collaborative culture while ensuring compliance and staff development in a dynam...
Yesterday
Advanced Practice Nurse- Sedalia Westwood
$85K - $100K *
Elevate community health by delivering comprehensive care as an Advanced Practice Nurse. Collaborate with a multidisciplinary team to assess, diagnose, and develop tailored treatment plans, ensuring p...
Yesterday
$95K - $115K *
Unlock the potential of HR technology by designing and implementing advanced Workday solutions. Collaborate with cross-functional teams to enhance integrations, reporting, and automation, driving oper...
1 week ago
Senior Engineer, Partner Integrations Platform
$145K - $160K *
Drive innovation by building scalable data integration solutions, collaborating with cross-functional teams to enhance healthcare technology. Ensure data quality and security while optimizing performa...
6 days ago
Healthcare Payment Sales Consultant
$157K - $192K *
Drive client engagement by orchestrating integrated payment solutions across diverse domains. Collaborate with teams to deliver customized strategies that enhance revenue growth and retention while si...
Reposted 4 days ago
Configuration Management (CfM) Analyst
$96K - $148K *
Unlock potential by managing configuration data integrity and processes. Collaborate with teams to design workflows in ServiceNow, ensuring accurate configuration management while driving continuous i...
1 week ago
$130K - $155K *
Lead the AI/ML product strategy across multiple business units, driving integration and data-centric solutions that enhance customer value and revenue growth through innovative workflows and collabora...
6 days ago
Compliance Analyst II - Remote
$80K - $95K *
Elevate compliance standards by enhancing AML and OFAC programs. Collaborate with cross-functional teams to mitigate financial crime risks while ensuring adherence to regulatory requirements and lever...
2 weeks ago
$190K - $200K *
Elevate your career by driving sales strategy and execution for a dynamic SaaS portfolio. Lead a high-performing team to achieve revenue growth, optimize pipeline management, and enhance customer acqu...
1 week ago
$63K - $140K *
Transform financial planning processes by designing and maintaining Anaplan models. Collaborate with FP&A teams to translate business needs into scalable solutions, ensuring accurate data integration...
2 weeks ago
$120K - $150K *
Shape the future of brand strategy by leading integrated initiatives, translating insights into actionable plans, and collaborating with cross-functional teams to deliver impactful solutions across as...
3 weeks ago
Advanced Practice Nurse - Employee Occupational Health Nurse Practitioner
$90K - $110K *
Unlock potential by providing comprehensive employee health services, focusing on safety, wellness, and disease prevention. Collaborate with teams to enhance health education and ensure a safe work en...
Yesterday
Associate Director, Analytics Governance & Operations
$152K - $283K *
Accelerate analytics governance and operations by leading initiatives that enhance decision-making processes, streamline reporting, and modernize workflows across teams, ensuring effective collaborati...
1 week ago
Coding Quality Reviewer and Educator-4
$67K - $111K *
Transform coding quality through comprehensive audits and targeted education, ensuring compliance with regulations and optimal revenue integrity. Leverage expert knowledge to identify trends and enhan...
Yesterday
Continuous Service Improvement/Operational Excellence Analyst
$76K - $105K *
Support day-to-day operations for investment teams, collaborating across functions to enhance processes, manage budgets, and drive special projects from planning to implementation, ensuring alignment...
Yesterday
$75K - $105K *
Empower healthcare delivery by ensuring coding accuracy as you analyze medical records, identify improvement opportunities, and enhance AI diagnostic models to uphold high-quality standards in inpatie...
Reposted 1 month ago
$100K - $120K *
Transform payment strategies by analyzing interchange and routing data to optimize costs and enhance performance. Leverage advanced analytics and automation to deliver actionable insights for stakehol...
5 days ago
(Remote) Cyber Vulnerability Assessment Analyst Senior - Cyber Security
$108K - $130K *
Join a team that's dedicated to enhancing cybersecurity by assessing vulnerabilities across enterprise systems and guiding remediation efforts. This senior role offers mentorship opportunities while d...
Reposted 2 days ago
$85K - $98K *
Join a dynamic team to evaluate and enhance the financial health of affordable housing organizations nationwide. Utilize advanced analytics and strategic insights to support sustainable growth and ris...
3 weeks ago
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.