Explore High-Paying Jobs in Missouri

Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.

Career Opportunities Across Missouri

Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.

Find Roles That Match Your Goals

Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.

Build Your Career in the Show-Me State

From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.

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$83K - $107K *

Champion innovative solutions in Epic Home Care systems to enhance clinical workflows and patient outcomes. Collaborate with leaders, mentor teams, and drive strategic initiatives in a dynamic, remote...

United StatesRemote

2 days ago

  •   Less than 5 years exp.  •   Healthcare

$109K - $125K *

Unlock potential by transforming complex data into actionable insights that drive enterprise strategy and decision-making. Collaborate across teams to develop reporting tools and metrics that enhance...

United StatesRemote

2 days ago

  •   5 - 7 years exp.  •   Finance & Insurance

$73K - $110K *

Elevate your career by ensuring coding accuracy and compliance in a dynamic healthcare environment. Collaborate with teams to enhance documentation quality and drive improvements in coding practices w...

RemoteRemote

Reposted 2 days ago

  •   5 - 7 years exp.  •   Healthcare

$95K - $115K *

Unlock potential by leading analytics initiatives, transforming data into actionable insights, and mentoring junior analysts. Collaborate with stakeholders to enhance reporting solutions and drive ope...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$110K - $130K *

Drive healthcare transformation by leading advanced consulting initiatives, enhancing delivery systems, and improving health outcomes. Collaborate with clients and stakeholders to implement strategic...

United StatesRemote

3 weeks ago

  •   11 - 15 years exp.  •   Healthcare

$120K - $145K *

Lead the design and governance of clinical ontologies and terminology services, ensuring data quality and alignment with product needs. Collaborate cross-functionally to enhance data normalization and...

United StatesRemote

5 days ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $90K *

Join a team that's dedicated to strategic program execution and risk mitigation. As a key analyst, you'll prepare and evaluate initiatives, collaborate across functions, and drive project success thro...

United StatesRemote

Today

  •   Less than 5 years exp.  •   Staffing

$63K - $100K *

Lead the charge in optimizing care management for members with complex needs by assessing, developing, and coordinating tailored care plans. Collaborate with healthcare professionals to ensure effecti...

Today

  •   Less than 5 years exp.  •   Hospitals & Medical Centers

$88K - $105K *

Engage in complex EHR application analysis and configuration, collaborating with clinical teams to enhance system usage. Drive issue resolution and maintain application integrity in a remote setting...

6 days ago

  •   5 - 7 years exp.  •   Healthcare

$100K - $231K *

Transform healthcare outcomes by leading a team of Clinical Program Consultants to analyze data, optimize clinical programs, and drive strategic initiatives that enhance customer health and reduce cos...

RemoteRemote

Reposted 3 days ago

  •   5 - 7 years exp.  •   Pharmaceuticals & Biotech

$92K - $120K *

Advance the compensation function through strategic AI application, enhancing processes and decision-making. Collaborate with stakeholders to modernize systems, ensuring operational excellence and com...

United StatesRemote

Reposted today

  •   5 - 7 years exp.  •   Healthcare

$70K - $126K *

Contribute to impactful data analytics projects, leading efforts in Power BI and SQL to enhance business operations. Collaborate with teams to extract insights from healthcare data, ensuring complianc...

RemoteRemote

Today

  •   Less than 5 years exp.  •   Healthcare

$88K - $115K *

Empower organizational change by analyzing stakeholder needs and implementing effective strategies. Collaborate with leadership and teams to enhance processes, ensuring smooth transitions and measurab...

RemoteRemote

Today

  •   8 - 10 years exp.  •   Business Services

$86K - $118K *

Join a team that's dedicated to enhancing consumer experiences through innovative solutions. Leverage your technical expertise in a collaborative environment focused on continuous improvement and impa...

United StatesRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$154K - $196K *

Unlock potential by leading strategic government programs, managing P&L, and driving operational excellence. Oversee contract delivery, mentor staff, and foster client relationships to ensure growth a...

United StatesRemote

1 month ago

  •   8 - 10 years exp.  •   Healthcare

$80K - $95K *

Help us enhance federal human capital operations through independent analysis, strategic recommendations, and effective program delivery. Collaborate on data-driven insights to improve efficiency and...

United StatesRemote

Reposted 2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

$76K - $105K *

Lead the charge in optimizing and supporting application implementations, conducting needs assessments, and managing projects to enhance business processes and user experience for healthcare applicati...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$100K - $120K *

Join us to drive impactful data analysis that enhances product performance and operational effectiveness. Collaborate with cross-functional teams to uncover insights, develop KPIs, and translate compl...

United StatesRemote

3 weeks ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Unlock potential by managing system design, build, and support for applications, ensuring optimal functionality and user satisfaction while collaborating across teams to enhance workflows and resolve...

RemoteRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$68K - $105K *

Help us lead enterprise-wide incident responses and internal investigations into misconduct, ensuring compliance and effective fraud detection while collaborating across departments to uphold organiza...

RemoteRemote

Reposted 5 days ago

  •   5 - 7 years exp.  •   Healthcare

$75K - $105K *

Lead the charge in transforming recruitment processes within a healthcare ERP system. Collaborate with stakeholders to optimize functionality, ensure compliance, and enhance operational efficiency for...

1 week ago

  •   Less than 5 years exp.  •   Education, Government & Non-Profit

$74K - $95K *

Advance employee health compliance by managing OSHA programs and screenings for a remote clinical workforce. Ensure accurate record-keeping and support health inquiries while maintaining adherence to...

United StatesRemote

4 days ago

  •   Less than 5 years exp.  •   Healthcare

$79K - $127K *

Unlock insights into medical cost trends by leveraging data analytics. Collaborate with cross-functional teams to develop strategic recommendations, track program outcomes, and present findings clearl...

RemoteRemote

1 week ago

  •   5 - 7 years exp.  •   Healthcare

$80K - $95K *

Empower healthcare technology by enhancing clinical systems and integrations. Collaborate with IT and business stakeholders to optimize workflows, manage projects, and ensure system performance across...

United StatesRemote

1 week ago

  •   Less than 5 years exp.  •   Healthcare

$82K - $128K *

Shape data-driven strategies by developing and automating analytics solutions. Collaborate with cross-functional teams to enhance reporting capabilities and optimize operational performance in a dynam...

United StatesRemote

2 weeks ago

  •   Less than 5 years exp.  •   Healthcare

Frequently Asked Questions (FAQ)

  • What types of high-paying jobs can I find in Missouri?question toggle

    Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.

  • Do Missouri jobs on Ladders pay at least $100,000?question toggle

    Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.

  • Where in Missouri can I search for jobs?question toggle

    Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.

  • How can I find a Missouri job that fits my experience?question toggle

    Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.