Find your next career opportunity with Missouri jobs paying $100,000 or more on Ladders. Browse vetted professional roles across the state, from major employers in Kansas City and St. Louis to growing organizations in Springfield, Columbia, and other communities. Listings may include opportunities in technology, healthcare, finance, engineering, operations, and executive leadership.
Missouri’s diverse economy supports professional careers across industries such as financial services, healthcare, manufacturing, logistics, technology, and agriculture. Whether you’re looking for an established corporate role or a position with a growing organization, explore openings that match your experience, skills, and compensation goals.
Use Ladders to discover vetted jobs with salaries of at least $100,000. Review each listing for details about responsibilities, qualifications, location, and compensation, then focus your search on opportunities that align with your career plans. Job availability and salary details vary by employer and role.
From metropolitan career hubs to communities throughout Missouri, high-paying roles can offer different work environments and paths for advancement. Explore current listings and find professional opportunities that fit the way you want to work and grow.
Sales Account Executive (Healthcare)
$280K - $300K *
Drive new business growth by leveraging innovative automation solutions. Build lasting client relationships and serve as a trusted advisor in the Agentic Process Automation space, while exceeding sale...
3 weeks ago
VP, Sales - Global Client Services
$120K - $140K *
Transform global client relationships by driving revenue growth and strategic account management. Collaborate with C-suite executives to connect workplace culture and employee experience to measurable...
6 days ago
Assoc Field Access Dir, Derm, St Louis
$196K - $218K *
Unlock potential by providing expert access education and support to healthcare providers, minimizing barriers for patients through strategic collaboration and innovative solutions in a dynamic health...
2 weeks ago
Senior Information Systems Auditor
$135K - $150K *
Drive excellence by executing full-scope IT audits, ensuring compliance with federal standards, and enhancing system security. Collaborate with stakeholders to assess controls and recommend improvemen...
4 days ago
$110K - $130K *
Empower transformative telehealth solutions by designing and implementing robust software infrastructure. Join a dynamic team to innovate, automate, and streamline applications, impacting the healthca...
Reposted today
Senior Marketing Analytics Consultant
$100K - $125K *
Unlock potential by leveraging data to drive marketing strategies and insights. Collaborate with cross-functional teams to analyze customer behavior and quantify marketing impact, enhancing decision-m...
1 week ago
Clinical Care Manager, Transitions of Care
$69K - $101K *
Join us to enhance member health outcomes through holistic care management, collaborating with multidisciplinary teams to support individuals with complex needs. Utilize assessments and interventions...
3 weeks ago
$110K - $130K *
Join us to lead the development and execution of clinical study designs, ensuring effective project management and collaboration across teams. Your expertise will drive the success of clinical trials...
3 weeks ago
Analytics Advisor III (R-19951)
$110K - $130K *
Unlock potential by driving analytics and AI solutions for clients, managing a $10M+ portfolio. Collaborate with sales teams to identify opportunities, build value stories, and achieve aggressive sale...
2 weeks ago
$80K - $95K *
Join a team that's dedicated to expanding healthcare partnerships by identifying and nurturing relationships with hospitals. Drive innovative consignment solutions while collaborating with internal te...
6 days ago
Clinical Project Research Manager - EDS/RWE/NIS
$100K - $120K *
Elevate project outcomes by leading cross-functional teams to deliver clinical research projects on time and within budget, ensuring compliance with regulatory standards and client expectations while...
Reposted 1 week ago
Senior Reporting & Account Support Analyst
$74K - $124K *
Drive impactful financial and operational reporting, leveraging data analysis to support strategic decisions and enhance client performance. Collaborate across teams to standardize methodologies and i...
Yesterday
Clinical Genomics Advanced Practice Provider
$110K - $130K *
Unlock potential by joining a dynamic Clinical Oncology Team, where you'll leverage your oncology and genomics expertise to enhance point-of-care products, drive clinical workflows, and support person...
1 week ago
$81K - $110K *
Make your mark at a dynamic healthcare team, delivering compassionate dialysis care while collaborating with skilled professionals. Utilize your critical thinking in a fast-paced environment to enhanc...
Reposted 2 weeks ago
Manager, Network Management (National Health Systems)
$54K - $159K *
Champion contract negotiations by driving initiatives, cultivating relationships, and ensuring compliance with performance goals. Leverage expertise to support cost-saving strategies and enhance cross...
Reposted 1 week ago
Financial & Budget Management Analyst - Expert
$170K - $212K *
Lead the charge in strategic financial analysis, guiding senior leadership with data-driven insights on investments and resource allocation. Utilize your expertise to translate complex data into actio...
Reposted 1 week ago
Strategic Account Executive, Healthcare - West Coast
$125K - $150K *
Unlock potential by driving enterprise growth in the TOLA region through strategic sales. Engage with senior healthcare executives to transform patient experiences using AI, while managing complex sal...
Today
$80K - $128K *
Analyze and monitor security alerts, investigate threats, and enhance SOC processes. Collaborate with teams to ensure cybersecurity measures are effective, while documenting incidents and providing te...
1 week ago
$80K - $128K *
Elevate cybersecurity operations by monitoring threats, analyzing network traffic, and coordinating incident responses. Collaborate with teams to enhance security measures and mentor junior analysts w...
1 week ago
$100K - $120K *
Drive client success by enhancing revenue cycle performance and fostering strategic relationships with enterprise clients. Leverage expertise to implement solutions, manage risks, and ensure measurabl...
Reposted 2 days ago
Experienced Clinical Research Associate | Regionally Aligned Across US
$80K - $95K *
Join a dynamic team to oversee clinical research activities, ensuring compliance with regulatory standards and driving site performance. Collaborate with stakeholders to enhance patient safety and dat...
2 weeks ago
Senior Manager - Data Analytics
$146K - $229K *
Lead a dynamic analytics team to create trusted measures, ensure actionable insights, and foster partnerships for data integrity and impact measurement across business functions...
Yesterday
$88K - $105K *
Manage the feasibility study process by adapting surveys, ensuring quality checks, and monitoring site engagement. Collaborate with teams to execute strategies and maintain effective communication thr...
Today
$120K - $160K *
Transform data into actionable insights by owning the analytics pipeline from ingestion to visualization. Collaborate with cross-functional teams to create trusted models and metrics that empower deci...
1 week ago
Counsel - Artificial Intelligence & Innovation Governance
$115K - $192K *
Drive your career with a dynamic legal role focused on AI and emerging technologies. Collaborate across teams to navigate evolving regulations, provide strategic guidance, and support responsible inno...
Today
What types of high-paying jobs can I find in Missouri?
Missouri listings may include professional roles in technology, healthcare, finance, engineering, manufacturing, logistics, operations, and executive leadership. Available positions depend on current employer hiring needs.
Do Missouri jobs on Ladders pay at least $100,000?
Ladders focuses on vetted professional jobs with salaries of $100,000 or more. Review the individual listing for its compensation information and requirements.
Where in Missouri can I search for jobs?
Explore opportunities in cities such as Kansas City, St. Louis, Springfield, and Columbia, as well as other locations across Missouri. Availability varies by role and employer.
How can I find a Missouri job that fits my experience?
Browse current listings and compare responsibilities, qualifications, location, and compensation with your experience and career goals. Apply to positions that align with your background.